Evaluation of the genotoxic potential of different delivery methods of at-home bleaching gels: a single-blind, randomized clinical trial

2018 ◽  
Vol 23 (5) ◽  
pp. 2199-2206 ◽  
Author(s):  
Marcílio Jorge Fernandes Monteiro ◽  
Jéssica Bruna Corrêa Lindoso ◽  
Nikeila Chacon de Oliveira Conde ◽  
Luciana Mendonça da Silva ◽  
Alessandro D. Loguercio ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Delivery Methods ◽  
Genotoxic Potential ◽  
Bleaching Gels ◽  
Single Blind ◽  
At Home

Effect of Daily Usage Time of 4% Hydrogen Peroxide on the Efficacy and Bleaching-induced Tooth Sensitivity: A Single-blind Randomized Clinical Trial

2021 ◽  
Author(s):  
RMO Terra ◽  
KL da Silva ◽  
L Vochikovski ◽  
E Sutil ◽  
M Rezende ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hydrogen Peroxide ◽  
Patient Satisfaction ◽  
Randomized Clinical Trial ◽  
Color Change ◽  
T Test ◽  
Tooth Sensitivity ◽  
Anterior Teeth ◽  
Single Blind ◽  
At Home

Clinical Relevance Although color change was slightly lower in a 3-week 30-minutes/day protocol, than in the 120-minute protocol, this could be compensated by an extra week of bleaching. The advantage of the shorter protocol is the reduced daily application, making the procedure more comfortable for the patients. SUMMARY Objective: Compare the risk/intensity of tooth sensitivity (TS) and color change of a 30-minute vs. the recommended 120-minute application time of 4% hydrogen peroxide (HP) for at-home bleaching. Methods: A single-blind, parallel, randomized clinical trial was conducted with 92 adult patients with caries and restoration-free anterior teeth A2 or darker, randomly allocated to two groups. Bleaching trays containing 4% HP were used for three-weeks. A four-week regimen was also offered to the patients for the 30-min group after the end of the 3-week protocol. The color change was assessed with the Vita Classical (VITA Zahnfabrik, Bad Säckingen, Germany) and Vita Bleachedguide shade guides (VITA Zahnfabrik) and the Vita Easyshade spectrophotometer (VITA Zahnfabrik) at baseline, weekly, and 30 days after the bleaching. The absolute risk and the intensity of TS were assessed daily using the 0-10 visual analogue scale (VAS) and 5-point Numerical Rating Scale (NRS) scale, and patient satisfaction was recorded with a Likert 0-7 scale. Risk of TS (Fisher’s test), intensity of TS in NRS scale (Mann-Whitney test), VAS scale (t-test), and a color change (t-test) were compared. Results: The 30-minute group saw color change of around 1 SGU inferior to the 120-minute group in all-time assessments (p<0.05). After an extra week of bleaching, mean color change was similar (p>0.05). Patient satisfaction was high for both groups (p>0.05). Conclusions: A four-week protocol of at-home dental bleaching with 4% HP for 30 minutes/day whitened teeth similarly to the 120 minutes/day protocol, with low intensity of dental sensitivity and high patient satisfaction.

Influence of treatment duration on the efficacy of at-home bleaching with daytime application: a randomized clinical trial

2018 ◽  
Vol 23 (8) ◽  
pp. 3229-3237 ◽  
Author(s):  
Iria L. Darriba ◽  
Paloma Cabirta Melón ◽  
Ana García Sartal ◽  
Ignacio Ríos Sousa ◽  
Víctor Alonso de la Peña
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Treatment Duration ◽  
At Home

Longitudinal effect of curcumin-photodynamic antimicrobial chemotherapy in adolescents during fixed orthodontic treatment: a single-blind randomized clinical trial study

2014 ◽  
Vol 30 (8) ◽  
pp. 2059-2065 ◽  
Author(s):  
Marco Aurélio Paschoal ◽  
Cíntia Maria Zanin Moura ◽  
Fabiano Jeremias ◽  
Juliana Feltrin Souza ◽  
Vanderlei S. Bagnato ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Antimicrobial Chemotherapy ◽  
Orthodontic Treatment ◽  
Photodynamic Antimicrobial Chemotherapy ◽  
Single Blind

scholarly journals The Analgesic Effects of Bupivacaine and Magnesium Sulfate Combination, Bupivacaine, and Adrenaline Combination and Bupivacaine Alone on Post-cesarean Section Pain: A Randomized Clinical Trial

2018 ◽  
Vol 9 (4) ◽  
pp. 284-290
Author(s):  
Zinatossadat Bouzari ◽  
Seyedeh Rabeeh Rouhani ◽  
Ebrahim Alijanpour ◽  
Shahla Yazdani ◽  
Bahman Hasannasab ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cesarean Section ◽  
Magnesium Sulfate ◽  
Randomized Clinical Trial ◽  
Normal Saline ◽  
Repeated Measures ◽  
The Other ◽  
Hemodynamic Parameters ◽  
Analgesic Effects ◽  
Single Blind

Objectives: The present study was performed to compare the analgesic effects of bupivacaine and magnesium sulfate combination on post-cesarean (C) section pain. Materials and Methods: The present single-blind randomized clinical trial was conducted on 160 C-section candidates. The participants were randomly divided into four groups. When the fascia healed, the first group received 20 mL of 0.25% bupivacaine and the second group received 20 mL of 0.25% bupivacaine combined with subcutaneous adrenaline. In addition, both groups received 50 mL of intravenous normal saline. Further, the third group received subcutaneous bupivacaine and 50 mg/kg of magnesium sulfate and the fourth group received subcutaneous and intravenous normal saline as a placebo. The pain intensity was assessed 2, 6, 12, 18, and 24 hours after spinal anesthesia using the visual analogue scale (VAS) for pain. The dose of pethidine (as a standard analgesic) and hemodynamic parameters (i.e., heart rate [HR] and blood pressure [BP]) was recorded as well. The obtained data were then analyzed utilizing ANOVA, Tukey’s HSD, and repeated measures ANOVA tests. Results: The intensity of pain and the dose of pethidine decreased significantly in the combination of bupivacaine with magnesium compared to the other groups at all times (P < 0.001). However, diastolic BP significantly increased in the bupivacaine + adrenaline group in comparison with the other groups (P = 0.02). Conclusions: Overall, bupivacaine combination with magnesium sulfate is suitable for controlling post-cesarean section pain.

scholarly journals Effect of peer support on breastfeeding self-efficacy in ilamian primiparous women: A single-blind randomized clinical trial

2021 ◽  
Vol 10 (9) ◽  
pp. 3417
Author(s):  
Zolaykha Karamelahi ◽  
Razhan Chehreh ◽  
ShahnazTork Zahrani ◽  
AlerzaAkbarzadeh Baghban
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Peer Support ◽  
Self Efficacy ◽  
Primiparous Women ◽  
Single Blind
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