Evaluation of the genotoxic potential of different delivery methods of at-home bleaching gels: a single-blind, randomized clinical trial

2018 ◽  
Vol 23 (5) ◽  
pp. 2199-2206 ◽  
Author(s):  
Marcílio Jorge Fernandes Monteiro ◽  
Jéssica Bruna Corrêa Lindoso ◽  
Nikeila Chacon de Oliveira Conde ◽  
Luciana Mendonça da Silva ◽  
Alessandro D. Loguercio ◽  
...  
2021 ◽  
Author(s):  
RMO Terra ◽  
KL da Silva ◽  
L Vochikovski ◽  
E Sutil ◽  
M Rezende ◽  
...  

Clinical Relevance Although color change was slightly lower in a 3-week 30-minutes/day protocol, than in the 120-minute protocol, this could be compensated by an extra week of bleaching. The advantage of the shorter protocol is the reduced daily application, making the procedure more comfortable for the patients. SUMMARY Objective: Compare the risk/intensity of tooth sensitivity (TS) and color change of a 30-minute vs. the recommended 120-minute application time of 4% hydrogen peroxide (HP) for at-home bleaching. Methods: A single-blind, parallel, randomized clinical trial was conducted with 92 adult patients with caries and restoration-free anterior teeth A2 or darker, randomly allocated to two groups. Bleaching trays containing 4% HP were used for three-weeks. A four-week regimen was also offered to the patients for the 30-min group after the end of the 3-week protocol. The color change was assessed with the Vita Classical (VITA Zahnfabrik, Bad Säckingen, Germany) and Vita Bleachedguide shade guides (VITA Zahnfabrik) and the Vita Easyshade spectrophotometer (VITA Zahnfabrik) at baseline, weekly, and 30 days after the bleaching. The absolute risk and the intensity of TS were assessed daily using the 0-10 visual analogue scale (VAS) and 5-point Numerical Rating Scale (NRS) scale, and patient satisfaction was recorded with a Likert 0-7 scale. Risk of TS (Fisher’s test), intensity of TS in NRS scale (Mann-Whitney test), VAS scale (t-test), and a color change (t-test) were compared. Results: The 30-minute group saw color change of around 1 SGU inferior to the 120-minute group in all-time assessments (p<0.05). After an extra week of bleaching, mean color change was similar (p>0.05). Patient satisfaction was high for both groups (p>0.05). Conclusions: A four-week protocol of at-home dental bleaching with 4% HP for 30 minutes/day whitened teeth similarly to the 120 minutes/day protocol, with low intensity of dental sensitivity and high patient satisfaction.


2018 ◽  
Vol 23 (8) ◽  
pp. 3229-3237 ◽  
Author(s):  
Iria L. Darriba ◽  
Paloma Cabirta Melón ◽  
Ana García Sartal ◽  
Ignacio Ríos Sousa ◽  
Víctor Alonso de la Peña

2014 ◽  
Vol 30 (8) ◽  
pp. 2059-2065 ◽  
Author(s):  
Marco Aurélio Paschoal ◽  
Cíntia Maria Zanin Moura ◽  
Fabiano Jeremias ◽  
Juliana Feltrin Souza ◽  
Vanderlei S. Bagnato ◽  
...  

2018 ◽  
Vol 9 (4) ◽  
pp. 284-290
Author(s):  
Zinatossadat Bouzari ◽  
Seyedeh Rabeeh Rouhani ◽  
Ebrahim Alijanpour ◽  
Shahla Yazdani ◽  
Bahman Hasannasab ◽  
...  

Objectives: The present study was performed to compare the analgesic effects of bupivacaine and magnesium sulfate combination on post-cesarean (C) section pain. Materials and Methods: The present single-blind randomized clinical trial was conducted on 160 C-section candidates. The participants were randomly divided into four groups. When the fascia healed, the first group received 20 mL of 0.25% bupivacaine and the second group received 20 mL of 0.25% bupivacaine combined with subcutaneous adrenaline. In addition, both groups received 50 mL of intravenous normal saline. Further, the third group received subcutaneous bupivacaine and 50 mg/kg of magnesium sulfate and the fourth group received subcutaneous and intravenous normal saline as a placebo. The pain intensity was assessed 2, 6, 12, 18, and 24 hours after spinal anesthesia using the visual analogue scale (VAS) for pain. The dose of pethidine (as a standard analgesic) and hemodynamic parameters (i.e., heart rate [HR] and blood pressure [BP]) was recorded as well. The obtained data were then analyzed utilizing ANOVA, Tukey’s HSD, and repeated measures ANOVA tests. Results: The intensity of pain and the dose of pethidine decreased significantly in the combination of bupivacaine with magnesium compared to the other groups at all times (P < 0.001). However, diastolic BP significantly increased in the bupivacaine + adrenaline group in comparison with the other groups (P = 0.02). Conclusions: Overall, bupivacaine combination with magnesium sulfate is suitable for controlling post-cesarean section pain.


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