scholarly journals Depression, anxiety, and stress in oral lichen planus: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Teresa De Porras-Carrique ◽  
Miguel Ángel González-Moles ◽  
Saman Warnakulasuriya ◽  
Pablo Ramos-García
Keyword(s):  
Systematic Review ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Current Evidence ◽  
Specific Method ◽  
Prevalence Of Depression ◽  
Meta Regression ◽  
Meta Analyses ◽  
Oral Lichen

Abstract Objectives We present this systematic review and meta-analyses to evaluate current evidence on the prevalence of depression, anxiety, and stress in patients with oral lichen planus and their magnitude of association. Material and methods We searched PubMed, Embase, Web of Science, Scopus, PsycInfo, and Google Scholar for studies published before January 2021. We evaluated the quality of studies using a specific method for systematic reviews addressing prevalence questions, designed by the Joanna Briggs Institute. We carried out meta-analyses and performed heterogeneity, subgroups, meta-regression, and small-study effects analyses. Results Fifty-one studies (which recruited 6,815 patients) met the inclusion criteria. Our results reveal a high prevalence of depression (31.19%), anxiety (54.76%), and stress (41.10%) in oral lichen planus. Furthermore, OLP patients presented a significantly higher relative frequency than control group without OLP for depression (OR = 6.15, 95% CI = 2.73–13.89, p < 0.001), anxiety (OR = 3.51, 95% CI = 2.10–5.85, p < 0.001), and stress (OR = 3.64, 95% CI = 1.48–8.94, p = 0.005), showing large effect sizes. Subgroups meta-analyses showed the relevance of the participation of psychologists and psychiatrists in the diagnosis of depression, anxiety, and stress in patients with OLP. Multivariable meta-regression analysis showed the importance of the comorbidity of depression-anxiety in patients with OLP. Conclusions Our systematic review and meta-analysis show that patients with OLP suffer a higher prevalence of depression, anxiety, and stress, being more frequent than in general population. Clinical relevance In the dental clinic, especially dentists should be aware of depression, anxiety, and stress in OLP patients to achieve a correct referral.

scholarly journals Oral Lichen Planus and Dental Implants: Protocol and Systematic Review

2020 ◽  
Vol 9 (12) ◽  
pp. 4127
Author(s):  
Aina Torrejon-Moya ◽  
Constanza Saka-Herrán ◽  
Keila Izquierdo-Gómez ◽  
Antoni Marí-Roig ◽  
Albert Estrugo-Devesa ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dental Implants ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Total Sample ◽  
Current Evidence ◽  
Inclusion Criteria ◽  
Meta Analyses ◽  
Oral Lichen

A systematic review was conducted to answer the following PICO question: “Can patients diagnosed with oral lichen planus (OLP) be rehabilitated with dental implants as successfully as patients without OLP?”. A systematic review of the literature was done following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statements to gather available and current evidence of oral lichen planus and its relationship with dental implants. The synthesis of results was performed using a Binary Random-Effects Model meta-analysis. Summary measures were odds ratios (ORs), frequencies, and percentages comparing the survival rate of dental implants placed in patients with OLP vs. those in patients without OLP. The electronic search yielded 25 articles, after removing the duplicated ones, 24 articles were selected. Out of the 24 articles, only 15 fulfilled the inclusion criteria. According to the results of the meta-analysis, with a total sample of 48 patients with OLP and 49 patients without OLP, an odds ratio of 2.48 (95% CI 0.34–18.1) was established, with an I2 value of 0%. According to the Strength of Recommendation Taxonomy (SORT) criteria, level A can be established to conclude that patients with OLP can be rehabilitated with dental implants.

scholarly journals Hepatitis C virus infections in oral lichen planus: a systematic review and meta-analysis

2016 ◽  
Vol 61 (3) ◽  
pp. 282-287 ◽  
Author(s):  
NA Alaizari ◽  
SA Al-Maweri ◽  
HM Al-Shamiri ◽  
B Tarakji ◽  
B Shugaa-Addin
Keyword(s):  
Systematic Review ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Virus Infections ◽  
Oral Lichen

Evaluation of serum and salivary interferon-γ levels in patients with oral lichen planus: a systematic review and meta-analysis of case-control studies

2019 ◽  
Vol 127 (3) ◽  
pp. 210-217 ◽  
Author(s):  
Hamid Reza Mozaffari ◽  
Roohollah Sharifi ◽  
Mina Hayati ◽  
Mohammad Moslem Imani ◽  
Pia Lopez-Jornet ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Interferon Γ ◽  
Case Control ◽  
Case Control Studies ◽  
Oral Lichen

scholarly journals Association of Interferon-gamma Gene Polymorphism (+874 A/T) and Oral Lichen planus susceptibility: Systematic Review and Meta-Analysis

2019 ◽  
Vol 7 (3) ◽  
pp. 45-55
Author(s):  
paria motahari ◽  
Fatemeh Pournaghi Azar ◽  
Parisa Rasouly ◽  
◽  
◽  
...  
Keyword(s):  
Systematic Review ◽  
Gene Polymorphism ◽  
Lichen Planus ◽  
Interferon Gamma ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Oral Lichen

Worldwide prevalence of oral lichen planus: a systematic review and meta‐analysis

Oral Diseases ◽  
2020 ◽  
Author(s):  
Miguel Ángel González‐Moles ◽  
Saman Warnakulasuriya ◽  
Isabel González‐Ruiz ◽  
Lucía González‐Ruiz ◽  
Ángela Ayén ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Oral Lichen

scholarly journals Efficacy evaluation of photodynamic therapy for oral lichen planus: a systematic review and meta-analysis

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yuqing He ◽  
Jiaxin Deng ◽  
Yi Zhao ◽  
Huiqian Tao ◽  
Hongxia Dan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Diode Laser ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Lesion Size ◽  
Cochrane Library ◽  
Oral Lichen

Abstract Background Photodynamic therapy (PDT) is a new option for oral lichen planus (OLP) management; however, there are different opinions on the efficacy of PDT for OLP. The aim of this study was to comprehensively assess the efficacy of PDT in the treatment of OLP and compare PDT with steroid therapy. Methods A systematic review and meta-analysis were conducted to assess the curative effect of PDT. Five electronic databases were searched, PubMed, Web of Science, the Cochrane Library, Embase, and EBSCO up to 1 December, 2019. Random and fixed effects models for pooled estimates calculation were used and the Meta package of R was applied. Results Pooled estimates revealed that, after PDT, the lesion size decreased by 1.53 cm2 (95% confidence interval (CI): 0.71–2.35) after PDT and the partial response (PR) was 0.77 (95% CI: 0.65–0.85). The visual analogue scale (VAS) score decreased by 3.82 (95% CI: 2.80–4.85) and the Thongprasom sign score decreased by 1.33 (95% CI: 0.56–2.10) after PDT. Subgroup analyses revealed that the 5-aminolevulinic acid (5-ALA) was more effective than methylene blue (MB), with a PR of 0.87 (95% CI: 0.80–0.91). The topical use of 5-ALA yielded a better response than gargling methylene blue. In terms of VAS, the diode laser showed a better clinical PR in the treatment of OLP. In terms of changes in lesion size, the efficacy of the semiconductor laser was higher than that of the diode laser. PDT had a similar efficacy to topical corticosteroids, as shown by pooled estimates of five randomised controlled trials with 139 lesions. Conclusion This systematic review indicates that PDT is an effective treatment modality for the management of OLP. PDT is as effective as topical corticosteroid in the treatment of OLP and could be used for cases resistant to steroids or when steroids are contraindicated.

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