Reduced density of intramembranous particle clusters: freeze-fracture study of mdx mouse muscle plasma membrane

2003 ◽  
Vol 36 (1) ◽  
pp. 59-65 ◽  
Author(s):  
S. Shibuya ◽  
Yoshihiro Wakayama ◽  
Hiroaki Oniki
Keyword(s):  
Plasma Membrane ◽  
Freeze Fracture ◽  
Mdx Mouse ◽  
Intramembranous Particle ◽  
Mouse Muscle ◽  
Muscle Plasma Membrane ◽  
Fracture Study ◽  
Reduced Density

Freeze-fracture study of muscle plasma membrane in obligate carriers of Duchenne muscular dystrophy

Neurology ◽  
1983 ◽  
Vol 33 (10) ◽  
pp. 1346-1346 ◽  
Author(s):  
E. Bonilla ◽  
K. H. Fischbeck ◽  
D. L. Schotland
Keyword(s):  
Plasma Membrane ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Freeze Fracture ◽  
Muscle Plasma Membrane ◽  
Fracture Study

Changes in plasma membrane Ca-ATPase and stromal interacting molecule 1 expression levels for Ca2+ signaling in dystrophic mdx mouse muscle

2012 ◽  
Vol 303 (5) ◽  
pp. C567-C576 ◽  
Author(s):  
Tanya R. Cully ◽  
Joshua N. Edwards ◽  
Oliver Friedrich ◽  
D. George Stephenson ◽  
Robyn M. Murphy ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Plasma Membrane ◽  
Mdx Mouse ◽  
Wild Type ◽  
Mouse Muscle ◽  
Muscle Plasma Membrane ◽  
Partner Protein ◽  
Close Relationship ◽  
The Common ◽  
T System

The majority of the skeletal muscle plasma membrane is internalized as part of the tubular (t-) system, forming a standing junction with the sarcoplasmic reticulum (SR) membrane throughout the muscle fiber. This arrangement facilitates not only a rapid and large release of Ca2+ from the SR for contraction upon excitation of the fiber, but has also direct implications for other interdependent cellular regulators of Ca2+. The t-system plasma membrane Ca-ATPase (PMCA) and store-operated Ca2+ entry (SOCE) can also be activated upon release of SR Ca2+. In muscle, the SR Ca2+ sensor responsible for rapidly activated SOCE appears to be the stromal interacting molecule 1L (STIM1L) isoform of STIM1 protein, which directly interacts with the Orai1 Ca2+ channel in the t-system. The common isoform of STIM1 is STIM1S, and it has been shown that STIM1 together with Orai1 in a complex with the partner protein of STIM (POST) reduces the activity of the PMCA. We have previously shown that Orai1 and STIM1 are upregulated in dystrophic mdx mouse muscle, and here we show that STIM1L and PMCA are also upregulated in mdx muscle. Moreover, we show that the ratios of STIM1L to STIM1S in wild-type (WT) and mdx muscle are not different. We also show a greater store-dependent Ca2+ influx in mdx compared with WT muscle for similar levels of SR Ca2+ release while normal activation and deactivation properties were maintained. Interestingly, the fiber-averaged ability of WT and mdx muscle to extrude Ca2+ via PMCA was found to be the same despite differences in PMCA densities. This suggests that there is a close relationship among PMCA, STIM1L, STIM1S, Orai1, and also POST expression in mdx muscle to maintain the same Ca2+ extrusion properties as in the WT muscle.

Distribution of intramembranous particle size in the muscle plasma membrane of the mdx mouse

1997 ◽  
Vol 148 (2) ◽  
pp. 147-151 ◽  
Author(s):  
Hijiri Ito ◽  
Toshiro Yoshimura ◽  
Mitsuhiro Tsujihata ◽  
Shigenobu Nagataki
Keyword(s):  
Particle Size ◽  
Plasma Membrane ◽  
Mdx Mouse ◽  
Intramembranous Particle ◽  
Muscle Plasma Membrane

Freeze–fracture analysis of muscle plasma membrane in Becker's muscular dystrophy

1994 ◽  
Vol 20 (5) ◽  
pp. 487-494 ◽  
Author(s):  
S. Shibuya ◽  
Y. Wakayama ◽  
T. Jimi ◽  
H. Oniki ◽  
T. Kobayashi ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Muscular Dystrophy ◽  
Freeze Fracture ◽  
Fracture Analysis ◽  
Muscle Plasma Membrane

Freeze fracture studies of muscle plasma membrane in human muscular dystrophy

1981 ◽  
Vol 54 (3) ◽  
pp. 189-197 ◽  
Author(s):  
D. L. Schotland ◽  
E. Bonilla ◽  
Y. Wakayama
Keyword(s):  
Plasma Membrane ◽  
Muscular Dystrophy ◽  
Freeze Fracture ◽  
Muscle Plasma Membrane

Distribution of freeze fracture particle sizes in Duchenne muscle plasma membrane

Neurology ◽  
1984 ◽  
Vol 34 (4) ◽  
pp. 534-534 ◽  
Author(s):  
K. H. Fischbeck ◽  
E. Bonilla ◽  
D. L. Schotland
Keyword(s):  
Plasma Membrane ◽  
Freeze Fracture ◽  
Particle Sizes ◽  
Muscle Plasma Membrane ◽  
Fracture Particle
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