Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese Population

Objective: To investigate the role of a functional polymorphism consisting of an aspartic acid (D) repeat located in the asporin gene (ASPN) gene in the susceptibility to and clinical outcome of ankylosing spondylitis (AS). Methods: A total of 374 Chinese patients with ankylosing spondylitis and 421 controls of the same ethnic origin matched for age and sex were included in the study. The asporin D repeat polymorphism was genotyped by polymerase chain reaction with a fluorescent primer. Results: Significant differences between AS patients and controls were detected in the distribution of the 7 alleles found in our population. D14 and D16 alleles were significantly over-represented in AS patients (D14, P=0.001, odds ratio (OR)=1.857, 95% confidence interval(CI) 1.27-2.715; and D16, P < 0.0001, OR=2.605, 95% CI 1.75-3.879). D16 over-representation was more common in early-onset patients than in late-onset patients, although the difference did not reach significance (P= 0.071). Conclusion: The results support a role for an asporin D repeat polymorphism in the susceptibility to AS and an influence of this gene on the outcome of the disease. D14 and D16 allele variants of ASPN might be the susceptibility alleles for AS in the Han Chinese population, whereas the D13 allele variant may have a protective effect on the onset of AS.

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An intron polymorphism of the fibronectin gene is associated with end-stage knee osteoarthritis in a Han Chinese population: two independent case- control studies

BMC Musculoskeletal Disorders ◽

10.1186/1471-2474-15-173 ◽

2014 ◽

Vol 15 (1) ◽

Cited By ~ 2

Author(s):

Hsin-Yi Yang ◽

Sui-Lung Su ◽

Yi-Jen Peng ◽

Chih-Chien Wang ◽

Herng-Sheng Lee ◽

...

Keyword(s):

Knee Osteoarthritis ◽

Chinese Population ◽

Case Control ◽

Han Chinese ◽

Case Control Studies ◽

Han Chinese Population ◽

Independent Case ◽

End Stage ◽

Intron Polymorphism

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Correlation Between Single Nucleotide Polymorphisms in Cxcr4 Microrna Binding Site and the Susceptibility to Knee Osteoarthritis in Han Chinese Population

10.21203/rs.3.rs-34363/v1 ◽

2020 ◽

Author(s):

Yang Wang ◽

Yanlin Li ◽

Di Jia ◽

Jiali Zheng ◽

Guoliang Wang

Keyword(s):

Plasma Level ◽

Single Nucleotide Polymorphisms ◽

Knee Osteoarthritis ◽

Chinese Population ◽

Han Chinese ◽

Target Sequence ◽

Nucleotide Polymorphisms ◽

Microrna Target ◽

Single Nucleotide ◽

Han Chinese Population

Abstract Background:This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) at the microRNA target sequence in CXCR4 and the susceptibility to knee osteoarthritis (KOA).Methods:A total of 305 patients with KOA and 305 healthy controls were recruited into this study. The genotypes of CXCR4 rs1804029 and rs17848060 loci were analyzed.Results:The susceptibility to KOA of CXCR4 rs1804029 G allele carriers was 1.33 times that of T allele carriers. The KOA susceptibility in individuals carrying T allele at CXCR4 rs17848060 locus was 1.38 times that of individuals carrying A allele (95% CI: 1.17-1.57, p < 0.001). The G allele at CXCR4 rs1804029 locus was the target of hsa-miR-146a-3p, while the A allele at CXCR4 rs17848060 locus could be targeted by hsa-miR-20a-3p. The plasma level of hsa-miR-146a-3p was lower in rs1804029 G allele carriers than T allele carriers, whereas plasma level of hsa-miR-20a-3p was higher in rs17848060 T allele carriers than A allele carriers.Conclusion:The SNPs at rs1804029 and rs17848060 loci in CXCR4 were significantly associated with the susceptibility to KOA in Han Chinese population.

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