Impact of bypass flow rate and catheter position in veno-venous extracorporeal membrane oxygenation on gas exchange in vivo

2014 ◽  
Vol 18 (2) ◽  
pp. 128-135 ◽  
Author(s):  
Konomi Togo ◽  
Yoshiaki Takewa ◽  
Nobumasa Katagiri ◽  
Yutaka Fujii ◽  
Satoru Kishimoto ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Extracorporeal Membrane Oxygenation ◽  
Flow Rate ◽  
Bypass Flow ◽  
Catheter Position ◽  
Membrane Oxygenation

scholarly journals Influence of extracorporeal membrane oxygenation on the pharmacokinetics of ceftolozane/tazobactam: an ex vivo and in vivo study

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Camille Mané ◽  
Clément Delmas ◽  
Jean Porterie ◽  
Géraldine Jourdan ◽  
Patrick Verwaerde ◽  
...  
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Ex Vivo ◽  
In Vivo Study ◽  
Membrane Oxygenation

Gas exchange across native lungs and extracorporeal membrane in neonates and pigs during extracorporeal membrane oxygenation

1994 ◽  
Vol 29 (8) ◽  
pp. 1016-1019 ◽  
Author(s):  
L.K.R. Shanbhogue ◽  
J.E.M. Vernooij ◽  
J.C. Molenaar ◽  
D. Tibboel
Keyword(s):  
Gas Exchange ◽  
Extracorporeal Membrane Oxygenation ◽  
Membrane Oxygenation

Computational Analysis of a Wearable Artificial Pump Lung Device in Terms of Rotor/Stator Interactions

2009 ◽  
Author(s):  
M. Ertan Taskin ◽  
Tao Zhang ◽  
Bartley P. Griffith ◽  
Zhongjun J. Wu
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Gas Exchange ◽  
Extracorporeal Membrane Oxygenation ◽  
Lung Disease ◽  
Computational Analysis ◽  
Respiratory Support ◽  
Membrane Oxygenation ◽  
Current Therapies

Lung disease is America’s third largest killer, and responsible for one in seven deaths [1]. Most lung disease is chronic, and respiratory support is essential. Current therapies for the respiratory failure include mechanical ventilation and bed-side extracorporeal membrane oxygenation (ECMO) devices which closely simulate the physiological gas exchange of the natural lung.

Poly-Methyl Pentene Oxygenators Have Improved Gas Exchange Capability and Reduced Transfusion Requirements in Adult Extracorporeal Membrane Oxygenation

ASAIO Journal ◽  
2005 ◽  
Vol 51 (3) ◽  
pp. 281-287 ◽  
Author(s):  
Espeed Khoshbin ◽  
Neil Roberts ◽  
Chris Harvey ◽  
David Machin ◽  
Hilliary Killer ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Extracorporeal Membrane Oxygenation ◽  
Membrane Oxygenation ◽  
Transfusion Requirements

Mechanisms of gas exchange with different gases during constant-flow ventilation

1990 ◽  
Vol 68 (1) ◽  
pp. 88-93 ◽  
Author(s):  
F. J. Chen ◽  
A. S. Menon ◽  
S. V. Lichtenstein ◽  
N. Zamel ◽  
A. S. Slutsky
Keyword(s):  
Gas Exchange ◽  
Physical Properties ◽  
Flow Rate ◽  
Constant Flow ◽  
Catheter Position ◽  
Arterial Pco2 ◽  
The Mean ◽  
The Difference ◽  
The Individual ◽  
Different Gases

To investigate the mechanisms responsible for the difference in gas exchange during constant-flow ventilation (CFV) when using gases with different physical properties, we used mixtures of 70% N2-30% O2 (N2-O2) and 70% He-30% O2 (He-O2) as the insufflating gases in 12 dogs. All dogs but one had higher arterial PCO2 (PaCO2) with He-O2 compared with N2-O2. At a flow of 0.37 +/- 0.12 l/s, the mean PaCO2's with N2-O2 and He-O2 were 41.3 +/- 13.9 and 53.7 +/- 20.3 Torr, respectively (P less than 0.01); at a flow rate of 0.84 +/- 0.17 l/s, the mean PaCO2's were 29.1 +/- 11.3 and 35.3 +/- 13.6 Torr, respectively (P less than 0.01). The chest was then opened to alter the apposition between heart and the lungs, thereby reducing the extent of cardiogenic oscillations by 58.4 +/- 18.4%. This intervention did not significantly alter the difference in PaCO2 between N2-O2 and He-O2 from that observed in the intact animals, although the individual PaCO2 values for each gas mixture did increase. When the PaCO2 was plotted against stagnation pressure (rho V2), the difference in PaCO2 between N2-O2 and He-O2 was nearly abolished in both the closed- and open-chest animals. These findings suggest that the different PaCO2's obtained by insufflating gases with different physical properties at a fixed flow rate, catheter position, and lung volume result mainly from a difference in the properties of the jet.

Gas exchange measurements in neonates treated with extracorporeal membrane oxygenation

1988 ◽  
Vol 23 (4) ◽  
pp. 306-311 ◽  
Author(s):  
Robert E. Cilley ◽  
John R. Wesley ◽  
Joseph B. Zwischenberger ◽  
Robert H. Bartlett
Keyword(s):  
Gas Exchange ◽  
Extracorporeal Membrane Oxygenation ◽  
Membrane Oxygenation

scholarly journals Pyruvate modifies metabolic flux and nutrient sensing during extracorporeal membrane oxygenation in an immature swine model

2015 ◽  
Vol 309 (1) ◽  
pp. H137-H146 ◽  
Author(s):  
Dolena R. Ledee ◽  
Masaki Kajimoto ◽  
Colleen M. O'Kelly Priddy ◽  
Aaron K. Olson ◽  
Nancy Isern ◽  
...  
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Metabolic Flux ◽  
Nutrient Sensing ◽  
Circulatory Support ◽  
Acid Oxidation ◽  
Swine Model ◽  
Hexosamine Biosynthetic Pathway ◽  
Membrane Oxygenation ◽  
Pyruvate Oxidation

Extracorporeal membrane oxygenation (ECMO) provides mechanical circulatory support for infants and children with postoperative cardiopulmonary failure. Nutritional support is mandatory during ECMO although specific actions for substrates on the heart have not been delineated. Prior work shows that enhancing pyruvate oxidation promotes successful weaning from ECMO. Accordingly, we tested the hypothesis that prolonged systemic pyruvate supplementation activates pyruvate oxidation in an immature swine model in vivo. Twelve male mixed-breed Yorkshire piglets (age 30–49 days) received systemic infusion of either normal saline (group C) or pyruvate (group P) during the final 6 h of 8 h of ECMO. Over the final hour, piglets received [2-13C] pyruvate, as a reference substrate for oxidation, and [13C6]-l-leucine, as an indicator for amino acid oxidation and protein synthesis. A significant increase in lactate and pyruvate concentrations occurred, along with an increase in the absolute concentration of the citric acid cycle intermediates. An increase in anaplerotic flux through pyruvate carboxylation in group P occurred compared with no change in pyruvate oxidation. Additionally, pyruvate promoted an increase in the phosphorylation state of several nutrient-sensitive enzymes, like AMP-activated protein kinase and acetyl CoA carboxylase, suggesting activation for fatty acid oxidation. Pyruvate also promoted O-GlcNAcylation through the hexosamine biosynthetic pathway. In conclusion, although prolonged pyruvate supplementation did not alter pyruvate oxidation, it did elicit changes in nutrient- and energy-sensitive pathways. Therefore, the observed results support the further study of pyruvate and its downstream effect on cardiac function.

The Effect of Decreasing Flow Rate on Cerebral Hemodynamics During Veno-Arterial Extracorporeal Membrane Oxygenation in Piglets

ASAIO Journal ◽  
2015 ◽  
Vol 61 (4) ◽  
pp. 448-452 ◽  
Author(s):  
Luella C. Gerrits ◽  
Arno F.J. van Heijst ◽  
Jeroen C.W. Hopman ◽  
Anton F.J. de Haan ◽  
Kian D. Liem
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Flow Rate ◽  
Cerebral Hemodynamics ◽  
Membrane Oxygenation

Efficiency in Extracorporeal Membrane Oxygenation—Cellular Deposits on Polymethypentene Membranes Increase Resistance to Blood Flow and Reduce Gas Exchange Capacity

ASAIO Journal ◽  
2008 ◽  
Vol 54 (6) ◽  
pp. 612-617 ◽  
Author(s):  
Karla Lehle ◽  
Alois Philipp ◽  
Otto Gleich ◽  
Andreas Holzamer ◽  
Thomas Müller ◽  
...  
Keyword(s):  
Blood Flow ◽  
Gas Exchange ◽  
Extracorporeal Membrane Oxygenation ◽  
Exchange Capacity ◽  
Membrane Oxygenation
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