scholarly journals Comparison of chronic widespread pain prevalence with different criteria in two cohorts of rheumatoid arthritis

2021 ◽  
Author(s):  
M. Aronsson ◽  
S. Bergman ◽  
E. Lindqvist ◽  
M. L. E. Andersson
Keyword(s):  
Rheumatoid Arthritis ◽  
Chronic Widespread Pain ◽  
Avoidance Behaviour ◽  
Widespread Pain ◽  
Fear Avoidance ◽  
Control Cohort ◽  
Tight Control ◽  
Pain Condition ◽  
Definition Of

Abstract Objective This study aims to investigate chronic widespread pain with the 1990 (CWP1990) and 2019 (CWP2019) definitions 6 years after the onset of rheumatoid arthritis (RA), in one patient cohort with tight controls and one conventional cohort, and factors associated with reporting CWP1990 and CWP2019, respectively. Methods A cohort of 80 RA patients with monthly visits to the physician the first 6 months was compared to a cohort of 101 patients from the same clinic with conventional follow-up. Both cohorts had early RA (< 13 months). The prevalence of CWP1990 and the more stringent CWP2019 were in a 6-year follow-up investigated with a questionnaire, including a pain mannequin and a fear-avoidance beliefs questionnaire. Results In the tight control cohort, 10% reported CWP2019 after 6 years compared to 23% in the conventional cohort (p = 0.026). There was no difference when using the CWP1990 definition (27% vs 31%, p = 0.546). When adjusted for important baseline data, the odds ratio for having CWP2019 was 2.57 (95% CI 1.02–6.50), in the conventional group compared to the tight control group (p = 0.046). A high level of fear-avoidance behaviour towards physical activity was associated with CWP2019, OR 10.66 (95% CI 1.01–112.14), but not with CWP1990 in the tight control cohort. Conclusion A more stringent definition of CWP identifies patients with a more serious pain condition, which potentially could be prevented by an initial tight control management. Besides tight control, caregivers should pay attention to fear-avoidance behaviour and tailor treatment. Key Points • CWP2019 is a more stringent definition of chronic widespread pain and identifies patients with a more serious pain condition. • Patients with a serious pain condition could be helped by frequent follow-ups. • This study suggests that a special attention of fear-avoidance behaviour towards physical activity in patients with RA is needed.

Are sleep problems and non-specific health complaints risk factors for chronic pain? A prospective population-based study with 17 year follow-up

2012 ◽  
Vol 3 (4) ◽  
pp. 210-217 ◽  
Author(s):  
Anne K. Nitter ◽  
Are H. Pripp ◽  
Karin Ø. Forseth
Keyword(s):  
Risk Factors ◽  
Chronic Pain ◽  
Sleep Problems ◽  
Population Based ◽  
Chronic Widespread Pain ◽  
Health Complaints ◽  
Widespread Pain ◽  
Population Based Study ◽  
Specific Health

AbstractIntroductionChronic musculoskeletal pain represents a significant health problem among adults in Norway. The prevalence of chronic pain can be up to 50% in both genders. However, the prevalence of chronic widespread pain is significantly higher in females than in males. Chronic widespread pain is seen as the end of a continuum of pain. There is rather sparse knowledge about the incidence of pain in initially pain free individuals and the course of self-reported pain over time. Moreover, little is known about risk factors for incidence of chronic pain or prognostic factors for the course of self-reported pain. We believe that such knowledge may contribute to develop strategies for treatment at an early stadium of the pain condition and thereby reduce the prevalence of chronic pain included chronic widespread pain.Aims of the studyThe aims of this study were threefold: (1) to calculate the incidence of self-reported musculoskeletal pain in a female cohort, (2) to describe the course of pain and (3) to investigate whether or not health complaints and sleep problems are predictive factors for onset of pain or prognostic factors for the course of pain.MethodsThis is a prospective population-based study of all women between 20 and 50 years who were registered in Arendal, Norway, in 1989 (N = 2498 individuals). A questionnaire about chronic pain (pain >3 months duration in muscles, joints, back or the whole body), modulating factors for pain, sleep problems and seven non-specific health complaints was mailed to all traceable women, in 1990 (N =2498), 1995 (n = 2435) and 2007 (n = 2261). Of these, 1338 responded on all three occasions. Outcome measures were presence and extent of chronic pain.ResultsThe prevalence of chronic pain was 57% in 1990 and 61% in 2007. From 1990 to 2007, 53% of the subjects changed pain category. The incidence of chronic pain in initially pain free individuals during follow-up was 44%, whereas the recovery rate was 25%. Impaired sleep quality predicted onset of chronic pain. There was a linear association between the number of health complaints and the incidence of chronic pain in initially pain free individuals. Equivalent results were found for persistence of pain and worsening of pain.ConclusionThe prevalence of chronic pain was rather stable throughout the follow-up period, but the prevalence of chronic widespread pain increased. Individual changes in pain extent occurred frequently. The presence of sleep disturbances and number of health complaints predicted onset, persistence and worsening of pain.ImplicationsSleep problems must be thoroughly addressed as a possible risk factor for onset or worsening of pain. Elimination of sleep problems in an early phase is an interesting approach in treating chronic pain. More research is needed to illuminate the possible pathogenetic relations between pain, non-specific health complaints, sleep problems and also depression.

Role of erosions typical of rheumatoid arthritis in the 2010 ACR/EULAR rheumatoid arthritis classification criteria: results from a very early arthritis cohort

2017 ◽  
Vol 76 (11) ◽  
pp. 1911-1914 ◽  
Author(s):  
Gina Hetland Brinkmann ◽  
Ellen S Norli ◽  
Pernille Bøyesen ◽  
Désirée van der Heijde ◽  
Lars Grøvle ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Early Arthritis ◽  
Classification Criteria ◽  
Erosive Disease ◽  
American College Of Rheumatology ◽  
Number Of Patients ◽  
Definition Of ◽  
Hands And Feet ◽  
Almost All

ObjectiveTo determine how the European League Against Rheumatism (EULAR) definition of erosive disease (erosion criterion) contributes to the number of patients classified as rheumatoid arthritis (RA) according to the 2010 American College of Rheumatology/EULAR RA classification criteria (2010 RA criteria) in an early arthritis cohort.MethodsPatients from the observational study Norwegian Very Early Arthritis Clinic with joint swelling ≤16 weeks, a clinical diagnosis of RA or undifferentiated arthritis, and radiographs of hands and feet were included. Erosive disease was defined according to the EULAR definition accompanying the 2010 RA criteria. We calculated the additional number of patients being classified as RA based on the erosion criteria at baseline and during follow-up.ResultsOf the 289 included patients, 120 (41.5%) fulfilled the 2010 RA criteria, whereas 15 (5.2%) fulfilled only the erosion criterion at baseline. 118 patients had radiographic follow-up at 2 years, of whom 6.8% fulfilled the 2010 RA criteria and only one patient fulfilled solely the erosion criterion during follow-up.ConclusionFew patients with early arthritis were classified as RA based on solely the erosion criteria, and of those who did almost all did so at baseline.

AB0848 IS THERE A WINDOW OF OPPORTUNITY IN EARLY PSORIATIC ARTHRITIS? RETROSPECTIVE DATA FROM A REAL LIFE SETTING

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1731-1731
Author(s):  
S. G. Werner ◽  
M. Vlachou ◽  
H. E. Langer ◽  
R. Chatelain
Keyword(s):  
Rheumatoid Arthritis ◽  
Psoriatic Arthritis ◽  
Morning Stiffness ◽  
Real Life ◽  
Window Of Opportunity ◽  
Tight Control ◽  
Real Life Setting ◽  
Significant Difference ◽  
Early Psoriatic Arthritis

Background:In early rheumatoid arthritis (ERA) a window of opportunity (WoO) is well established since its first proposal in 2002 (1). ERA patients achieved a better clinical outcome when DMARD therapy was initiated within the first 12-16 weeks after start of symptoms (disease duration (Xd) (2). To the best of our knowledge, comparable data are missing for early psoriatic arthritis (EPsA), even though the benefit of tight control is known in EPsA (3,4). In contrast to ERA early PsA is usually defined as Xd <24months (3,4).Objectives:To study in a setting of routine rheumatologic care if a WoO like in ERA also can be observed in EPsA comparable to ERA.Methods:n=90 consecutive outpatients with definite PsA were recruited in this retrospective longitudinal cohort study with the following inclusion criteria: DMARD- and steroid-naïve at the first time of visit in our outpatient clinic (t0), minimum follow-up of 3 years, classification as very early psoriatic arthritis (VEPsA, Xd≤3 months, n=30), late early psoriatic arthritis (LEPsA, > 3 Xd ≤ 12 months, n=30) and late psoriatic arthritis (LAPsA, Xd > 36 months, n=30). Standardized assessments had been performed at regular intervals of 3 months within the framework of routine rheumatologic care. Outcome at 3 years (t36) was analyzed within groups and between groups (DAS28, Physician Global Assessment (PhG), HAQ, fatigue, morning stiffness).Results:Cohorts did not differ between gender and age (mean age 54 years). There was no significant difference in DAS28, HAQ, PhG and morning stiffness at t0. Fatigue at t0 differed between cohort 1 and 3 significantly (p<0.03). In all cohorts DAS28 and PhG have been decreased at t36 significantly (minimal p< 0.006). In comparison to VEPsA LEPsA showed a significant difference in DAS28 (p<0.04) and PhG (p<0.05), but not in morning stiffness and fatigue. Highly significant differences between VEPsA and LAPsA were observed for DAS28 (p <0.007), morning stiffness (p < 0.001), PhG (p<0.05) and fatigue (p < 0.006) at t36.Conclusion:Significant and relevant differences between the outcomes at 3 years of patients with VEPsA, LEPsA and LAPsA could be identified in this retrospective pilot study. Particularly the highly significant difference between VEPsA and LAPsA (<3 months vs. >36months) is remarkable. The data suggest a window of opportunity also in patients with EPsA. With a time interval of Xd≤12 this window seems to be longer than in ERA. Further studies with higher number of patients were needed to confirm our findings from this real life setting.References:[1]O´Dell JR Treating Rheumatoid Arthritis Early: A Window of Opportunity? Arthritis Rheum 2002;46:283–285[2]Nell VPK, Machold KP, Eberl G, Stamm TA, Uffmann M, Smolen JS Rheumatology 2004 43:906-914[3]Coates LC, Moverley AR, McParland Let al. Effect of tight control of inflammation in early psoriatic arthritis (TICOPA): a UK multicentre, open-label, randomised controlled trial.Lancet2015,386:2489–98.[4]Coates LC, Mahmood F, Freeston J, Emery P, Conaghan PG, Helliwell PS Long-term follow-up of patients in the TIght COntrol of inflammation in early Psoriatic Arthritis (TICOPA) trial Rheumatology (Oxford) 2019 kez369Disclosure of Interests:None declared

scholarly journals P66 Risk factors for chronic widespread pain among older workers: findings from the Health and Employment After Fifty (HEAF) study

Rheumatology ◽  
2020 ◽  
Vol 59 (Supplement_2) ◽  
Author(s):  
Georgia Ntani ◽  
Stefania D'Angelo ◽  
Clare Harris ◽  
Cathy Linaker ◽  
Karen Walker-Bone
Keyword(s):  
Risk Factors ◽  
Older Workers ◽  
Chronic Widespread Pain ◽  
Psychosocial Aspects ◽  
Physical Workload ◽  
Widespread Pain ◽  
Self Rated Health ◽  
Personal Risk ◽  
Personal Risk Factors

Abstract Background Incident chronic widespread pain (CWP) is associated with demographic and personal risk factors such as low mood and somatisation. More recently, there has been increased focus on the role of workplace factors on CWP. However, evidence from studies exploring the interaction of demographic, personal risk factors, job activities and psychosocial aspects of work on pain in older workers is limited. We assessed several potential determinants of the onset of CWP among participants in the HEAF study, a prospective UK cohort. Methods A cohort of participants aged 50-64 years were recruited from 24 English general practices in 2013-14 and have been followed-up annually by postal questionnaire. At baseline, information was collected about demographic and employment circumstances, physical workload, psychosocial aspects of work and their general health, mood and well-being. At three years of follow-up, information about pain was also obtained by reporting painful sites on a body mannikin, and CWP was defined according to the ACR criteria. Associations between potential risk factors and the onset of new CWP were explored using logistic regression modelling. Effect estimates were summarised by odds ratios (OR) and 95% confidence intervals (CIs). Results HEAF recruited a total of 8,134 people aged 50-64 years at baseline. Among the N = 3,909 still at work at three years’ follow-up, N = 3,873 did not report CWP in the first two years of follow-up. The incidence of CWP at three years follow-up was 7.4% (males: 5.7%; females: 8.9%). Multivariate analyses showed that the strongest predictors of the onset of new CWP were: female sex (OR(95% CI): 1.7(1.2-2.3)), reporting that they have low expectations of coping with physical demands of the job (OR (95%CI): 2.1 (1.5-3.0)); somatisation (OR(95%CI): 2.1(1.3-3.2)) and poor self-rated health (OR(95%CI): 2.3(1.7-3.2)). Physical workload and other psychosocial aspects of work were also significantly associated with onset of CWP but with relatively smaller effect sizes (physical workload OR(95%CI): 1.2(1.1-1.3)); lack of appreciation OR (95% CI): 1.6(1.1-2.5)) Conclusion Our results complement previous findings that physical loading at work independently predicts the onset of CWP. However, personal risk factors like self-rated health and work-related expectations demonstrated stronger effects. These findings can inform future interventions for prevention of CWP. Disclosures G. Ntani None. S. D'Angelo None. C. Harris None. C. Linaker None. K. Walker-Bone None.

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