The impact of antimicrobial photodynamic therapy in an artificial biofilm model

2011 ◽  
Vol 27 (3) ◽  
pp. 615-620 ◽  
Author(s):  
Martin Schneider ◽  
Gregor Kirfel ◽  
Michael Berthold ◽  
Matthias Frentzen ◽  
Felix Krause ◽  
...  
2011 ◽  
Author(s):  
Martin Schneider ◽  
Gregor Kirfel ◽  
Michael Berthold ◽  
Olivier Brede ◽  
Matthias Frentzen ◽  
...  

2010 ◽  
Author(s):  
Martin Schneider ◽  
Gregor Kirfel ◽  
Felix Krause ◽  
Michael Berthold ◽  
Olivier Brede ◽  
...  

2017 ◽  
Vol 17 ◽  
pp. 236-244 ◽  
Author(s):  
Lívia Jacovassi Tavares ◽  
Ana Claudia Pavarina ◽  
Carlos Eduardo Vergani ◽  
Erica Dorigatti de Avila

2018 ◽  
Vol 52 (6) ◽  
pp. 447-453 ◽  
Author(s):  
Fabian Cieplik ◽  
Fabian Wimmer ◽  
Denise Muehler ◽  
Thomas Thurnheer ◽  
Georgios N. Belibasakis ◽  
...  

Antimicrobial photodynamic therapy (aPDT) may be useful as a supportive antimicrobial measure for caries-active subjects. In this study, the antimicrobial efficacy of aPDT with a phenalen-1-one photosensitizer was evaluated in a novel in vitro biofilm model comprising Actinomyces naeslundii, Actinomyces odontolyticus, and Streptococcus mutans and was compared to chlorhexidine. The proposed biofilm model allows high-throughput screening for antimicrobial efficacy while exhibiting a differentiated response to different antimicrobial approaches. While chlorhexidine 0.2% showed a reduction of ≈4 log10 for all species, aPDT led to a more pronounced reduction of S. mutans (2.8 log10) than of Actinomyces spp. (1.2 or 1.3 log10). A similar effect was also observed in monospecies biofilms. Therefore, aPDT may be more effective against S. mutans than against Actinomyces spp. when in biofilms, and this antimicrobial approach merits further investigations.


Author(s):  
Pier Poli ◽  
Francisley Avila Souza ◽  
Mattia Manfredini ◽  
Carlo Maiorana ◽  
Mario Beretta

Not required for Clinical case letters according to the authors' guidelines.


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