scholarly journals A detailed view of PLGA-mPEG microsphere formation by double emulsion solvent evaporation method

2015 ◽  
Vol 33 (7) ◽  
pp. 955-963 ◽  
Author(s):  
Shui-bin Feng ◽  
De-hao Fu ◽  
Lei Nie ◽  
Peng Zou ◽  
Jin-ping Suo
Keyword(s):  
Double Emulsion ◽  
Solvent Evaporation ◽  
Solvent Evaporation Method ◽  
Evaporation Method

scholarly journals Microencapsulation of Fucoxanthin by Water-in-Oil-in-Water (W/O/W) Double Emulsion Solvent Evaporation Method: A Review

2014 ◽  
Vol 9 (3) ◽  
pp. 137 ◽  
Author(s):  
Dedi Noviendri
Keyword(s):  
Cell Line ◽  
Colloidal Stability ◽  
Double Emulsion ◽  
Solvent Evaporation ◽  
Human Lung Cancer ◽  
Drug Candidate ◽  
Human Leukemia ◽  
Solvent Evaporation Method ◽  
Evaporation Method ◽  
Oil In Water

Fucoxanthin is a major xanthophyll present in brown seaweeds such as Sargassum binderi, S. duplicatum, Turbinaria turbinata, Padina australis, Undaria pinnatifida and Hijkia fusiformis. This carotenoid has a unique structure including oxygenic functional group such as, two hydroxy, keto, epoxy (5,6-monoepoxide), and an allenic bond. Fucoxanthin has some anticancer activities such as, exhibits inhibitory property on colon cancer cells and human hepatic carcinoma HepG2 cell line. This xanthophyll also induces apoptosis of human leukemia cancer HL-60 cells, human prostate cancer PC-3 cell, human lung cancer H1299 cell line etc. Unfortunately, the poor solubility of this carotenoid in water hinders it to be a drug candidate. Fucoxanthin is also a pigment that is sensitive to temperature and light. One of the possible ways to circumvent the problem with light and temperature is by microencapsulating it. Microencapsulation (ME) in biodegradable polymers, e.g. poly(D,L-lactic-co-glycolic acid) (PLGA) is a promising approach to protect any potential drug from rapid degradation. Solvent evaporation method is the most popular technique of preparing PLGA microsphere (MS) and this technique has been extensively studied in recent years for the preparation of MS. In the water-in-oil-in-water (w/o/w) double emulsion solvent evaporation method, stability of the primary emulsion (PE) is a critical factor. When the PE is unstable, encapsulation efficiency (EE) is low. Stability of PE can be enhanced by including emulsifying agent or stabilizers such as polyvinyl alcohol (PVA). The presence of a stabilizer/ emulsifier plays a significant role in influencing particle size (PS), external morphology of microsphere and colloidal stability.  

A Study on Chitosan Coated Polycaprolactone (Ch-PCL) Microspheres Prepared via Double Smulsion Solvent Evaporation Method

2020 ◽  
Vol 1010 ◽  
pp. 541-548
Author(s):  
Zi Yang Te ◽  
Wei Heng Yeoh ◽  
Muhammad Ashraf Shahidan ◽  
Nur Nabilah Shahidan
Keyword(s):  
Polymer Concentration ◽  
Double Emulsion ◽  
Average Diameter ◽  
Storage Condition ◽  
Solvent Evaporation ◽  
Particle Sizes ◽  
Solvent Evaporation Method ◽  
Evaporation Method ◽  
Oil Fraction ◽  
Nacl Concentration

Polycaprolactone coated with chitosan microspheres have the potential to be used as delivery systems and biosensors. Polycaprolactone (PCL) is, however hydrophobic, to improve the biofunctional and potential immobilization of PCL polymer, chitosan-coated PCL microspheres (MSs) were prepared using a double emulsion solvent evaporation method. Different particle sizes were prepared by altering five parameters. When the MSs were prepared using oil to water phase ratio or oil fraction (ϕo) of ϕo = 0.95 to ϕo = 0.38, the MSs average diameter (Dv) reduced from 3.86 to 3.53 µm along with its coefficient of variation (CV), reduced from 18.1 to 12.3 respectively. The MSs prepared with higher polymer concentration of 6wt.% shows higher Dv (4.51 µm) and CV (25.2) compared to 1.2wt.% of PCL, which Dv = 3.86 µm with CV of 18.1. The first homogenizer speed (H1) was increased in order to prepare smaller MSs. When H1 increased from 6 000 to 10 000 rpm, MSs Dv reduced from 3.86 to 3.45 µm along with its CV reduce from 18.1 to 16.6 for ϕo = 0.95. It is also the same case for ϕo = 0.52, where the Dv reduced from 3.70 to 3.19 µm and its CV reduce from 25.8 to 25.2. The effect of NaCl concentration on MSs preparation shows, higher NaCl concentration (1.8wt.%) produced smaller Dv(Dv = 3.86 µm) compared to lower concentration of 0.9wt.%, produced Dv = 4.51 µm for ϕo = 0.95. The trend also follows when the MSs were prepared for ϕo = 0.52. The delay in adding the NaCl shows distinct effect on Dv. For both 0.9 and 1.8 wt.% of NaCl, the Dv increase from 4.51 to 6.40 µm and 4.31 to 6.17 µm respectively. Therefore, the targeted Dv for certain application could be achieved by altering the parameters above. Finally, to study the Ch-PCL potential as enzyme immobilizer, horseradish peroxidase (HRP) was used to be immobilized on to the Ch-PCL MSs. After 7 days, the HRP enzyme still show 51% activity under robust storage condition.

Glibenclamide-Nicotinamide Cocrystals Synthesized by The Solvent Evaporation Method to Enhance Solubility and Dissolution Rate of Glibenclamide

2019 ◽  
Vol 9 (01) ◽  
pp. 21-26
Author(s):  
Arif Budiman ◽  
Ayu Apriliani ◽  
Tazyinul Qoriah ◽  
Sandra Megantara
Keyword(s):  
Solvent Evaporation ◽  
Physical Mixture ◽  
Dissolution Profile ◽  
Solvent Evaporation Method ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Evaporation Method ◽  
Dissolution Properties ◽  
Mixture Characterization

Purpose: To develop glibenclamide-nicotinamide cocrystals with the solvent evaporation method and evaluate their solubility and dissolution properties. Methods: Cocrystals of glibenclamide-nicotinamide (1:2) were prepared with the solvent evaporation method. The prediction of interactive cocrystals was observed using in silico method. The solubility and dissolution were performed as evaluation of cocrystals. The cocrystals also were characterized by differential scanning calorimetry (DSC), infrared spectrophotometry, and powder X-ray diffraction (PXRD). Result: The solubility and dissolution profile of glibenclamide-nicotinamide cocrystal (1:2) increased significantly compared to pure glibenclamide as well as its physical mixture. Characterization of cocrystal glibenclamide-nicotinamide (1:2) including infrared Fourier transform, DSC, and PXRD, indicated the formation of a new solid crystal phase differing from glibenclamide and nicotinamide. Conclusion: The confirmation of cocrystal glibenclamide-nicotinamide (1:2) indicated the formation of new solid crystalline phases that differ from pure glibenclamide and its physical mixture

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