Clinical usefulness of KRAS, BRAF, and PIK3CA mutations as predictive markers of cetuximab efficacy in irinotecan- and oxaliplatin-refractory Japanese patients with metastatic colorectal cancer

Hiroshi Soeda; Hideki Shimodaira; Mika Watanabe; Takao Suzuki; Makio Gamoh; Takahiro Mori; Keigo Komine; Noriyuki Iwama; Shunsuke Kato; Chikashi Ishioka

doi:10.1007/s10147-012-0422-8

Clinical usefulness of KRAS, BRAF, and PIK3CA mutations as predictive markers of cetuximab efficacy in irinotecan- and oxaliplatin-refractory Japanese patients with metastatic colorectal cancer

International Journal of Clinical Oncology ◽

10.1007/s10147-012-0422-8 ◽

2012 ◽

Vol 18 (4) ◽

pp. 670-677 ◽

Cited By ~ 16

Author(s):

Hiroshi Soeda ◽

Hideki Shimodaira ◽

Mika Watanabe ◽

Takao Suzuki ◽

Makio Gamoh ◽

...

Keyword(s):

Colorectal Cancer ◽

Metastatic Colorectal Cancer ◽

Japanese Patients ◽

Predictive Markers ◽

Clinical Usefulness ◽

Pik3ca Mutations

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A retrospective observational study of clinicopathological features of KRAS, NRAS, BRAF and PIK3CA mutations in Japanese patients with metastatic colorectal cancer

BMC Cancer ◽

10.1186/s12885-015-1276-z ◽

2015 ◽

Vol 15 (1) ◽

Cited By ~ 47

Author(s):

Akihito Kawazoe ◽

Kohei Shitara ◽

Shota Fukuoka ◽

Yasutoshi Kuboki ◽

Hideaki Bando ◽

...

Keyword(s):

Colorectal Cancer ◽

Observational Study ◽

Metastatic Colorectal Cancer ◽

Japanese Patients ◽

Clinicopathological Features ◽

Retrospective Observational Study ◽

Pik3ca Mutations

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Associations between deepness of response and clinical outcomes among Japanese patients with metastatic colorectal cancer treated with second-line FOLFIRI plus cetuximab

OncoTargets and Therapy ◽

10.2147/ott.s87101 ◽

2015 ◽

pp. 2005 ◽

Cited By ~ 2

Author(s):

Hiroki Osumi ◽

Satoshi Matsusaka ◽

Mitsukuni Suenaga ◽

Eiji Shinozaki ◽

Nobuyuki Mizunuma

Keyword(s):

Colorectal Cancer ◽

Metastatic Colorectal Cancer ◽

Clinical Outcomes ◽

Japanese Patients ◽

Second Line

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Phase I/II Study of Capecitabine Plus Oxaliplatin (XELOX) Plus Bevacizumab As First-line Therapy in Japanese Patients with Metastatic Colorectal Cancer

Japanese Journal of Clinical Oncology ◽

10.1093/jjco/hyq069 ◽

2010 ◽

Vol 40 (10) ◽

pp. 913-920 ◽

Cited By ~ 29

Author(s):

T. Doi ◽

N. Boku ◽

K. Kato ◽

Y. Komatsu ◽

K. Yamaguchi ◽

...

Keyword(s):

Colorectal Cancer ◽

Phase I ◽

Metastatic Colorectal Cancer ◽

Japanese Patients ◽

First Line ◽

First Line Therapy ◽

Line Therapy

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Role ofNRASmutations as prognostic and predictive markers in metastatic colorectal cancer

International Journal of Cancer ◽

10.1002/ijc.28955 ◽

2014 ◽

Vol 136 (1) ◽

pp. 83-90 ◽

Cited By ~ 64

Author(s):

Marta Schirripa ◽

Chiara Cremolini ◽

Fotios Loupakis ◽

Manfredi Morvillo ◽

Francesca Bergamo ◽

...

Keyword(s):

Colorectal Cancer ◽

Metastatic Colorectal Cancer ◽

Predictive Markers ◽

Prognostic And Predictive Markers

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Combination chemotherapy of biweekly irinotecan (CPT-11) plus tegafur/uracil (UFT) and leucovorin (LV) for patients with metastatic colorectal cancer: phase I/II study in Japanese patients

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-008-0765-z ◽

2008 ◽

Vol 63 (3) ◽

pp. 501-507 ◽

Cited By ~ 5

Author(s):

Koji Okabayashi ◽

Hirotoshi Hasegawa ◽

Yoshiyuki Ishii ◽

Takashi Endo ◽

Hiroki Ochiai ◽

...

Keyword(s):

Colorectal Cancer ◽

Phase I ◽

Metastatic Colorectal Cancer ◽

Combination Chemotherapy ◽

Japanese Patients

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Randomized Phase II Trial of CapOX plus Bevacizumab and CapIRI plus Bevacizumab as First‐Line Treatment for Japanese Patients with Metastatic Colorectal Cancer (CCOG‐1201 Study)

The Oncologist ◽

10.1634/theoncologist.2017-0640 ◽

2018 ◽

Vol 23 (8) ◽

pp. 919-927 ◽

Cited By ~ 1

Author(s):

Goro Nakayama ◽

Ayako Mitsuma ◽

Yuki Sunagawa ◽

Kiyoshi Ishigure ◽

Hiroyuki Yokoyama ◽

...

Keyword(s):

Colorectal Cancer ◽

Metastatic Colorectal Cancer ◽

Phase Ii ◽

Phase Ii Trial ◽

Japanese Patients ◽

Line Treatment ◽

First Line ◽

Randomized Phase Ii ◽

First Line Treatment

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Clinical Outcome of Cetuximab for Metastatic Colorectal Cancer Patients Harboring Kras CODON61, Kras CODON146, Braf, Nras or PIK3CA Mutations

Annals of Oncology ◽

10.1016/s0923-7534(20)33185-9 ◽

2012 ◽

Vol 23 ◽

pp. ix196-ix197 ◽

Cited By ~ 1

Author(s):

E. Shinozaki ◽

H. Bando ◽

T. Nishina ◽

K. Yamazaki ◽

S. Kadowaki ◽

...

Keyword(s):

Colorectal Cancer ◽

Clinical Outcome ◽

Metastatic Colorectal Cancer ◽

Cancer Patients ◽

Pik3ca Mutations ◽

Colorectal Cancer Patients

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Retrospective analysis of capecitabine and oxaliplatin (XELOX) plus bevacizumab as a first-line treatment for Japanese patients with metastatic colorectal cancer

Molecular and Clinical Oncology ◽

10.3892/mco.2013.205 ◽

2013 ◽

Vol 2 (1) ◽

pp. 134-138 ◽

Cited By ~ 4

Author(s):

YASUTAKE UCHIMA ◽

TAKAFUMI NISHII ◽

YASUHITO ISEKI ◽

MARIKO ISHII ◽

SOICHIRO HIRAMATSU ◽

...

Keyword(s):

Colorectal Cancer ◽

Metastatic Colorectal Cancer ◽

Retrospective Analysis ◽

Japanese Patients ◽

Line Treatment ◽

First Line ◽

First Line Treatment

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Capecitabine and oxaliplatin combined with bevacizumab are feasible for treating selected Japanese patients at least 75 years of age with metastatic colorectal cancer

BMC Cancer ◽

10.1186/s12885-015-1712-0 ◽

2015 ◽

Vol 15 (1) ◽

Cited By ~ 9

Author(s):

Yoshinori Munemoto ◽

Mitsuro Kanda ◽

Keiichiro Ishibashi ◽

Taishi Hata ◽

Michiya Kobayashi ◽

...

Keyword(s):

Colorectal Cancer ◽

Metastatic Colorectal Cancer ◽

Japanese Patients

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Cross-platform comparison of NGS and MALDI-TOF for detecting RAS/RAF/PIK3CA mutations in circulating tumor DNA from metastatic colorectal cancer patient plasma

Annals of Oncology ◽

10.1093/annonc/mdy281.094 ◽

2018 ◽

Vol 29 ◽

pp. viii183

Author(s):

L. Liang ◽

B.-L. Wang ◽

Q. Yu ◽

T.-S. Liu ◽

W. Guo

Keyword(s):

Colorectal Cancer ◽

Cancer Patient ◽

Metastatic Colorectal Cancer ◽

Colorectal Cancer Patient ◽

Circulating Tumor Dna ◽

Pik3ca Mutations ◽

Platform Comparison ◽

Cross Platform ◽

Metastatic Colorectal Cancer Patient ◽

Tumor Dna

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