Ratio of serum creatinine to cystatin C is related to leg strength in predialysis CKD patients

AbstractGlomerular filtration rate (GFR) is difficult to measure, and estimating formulas are notorious for lacking precision. This study aims to assess if the inclusion of additional biomarkers improves the performance of eGFR formulas. A hundred and sixteen children with renal diseases were enrolled. Data for age, weight, height, inulin clearance (iGFR), serum creatinine, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), parathyroid hormone (PTH), albumin, and brain natriuretic peptide (BNP) were collected. These variables were added to the revised and combined (serum creatinine and cystatin C) Schwartz formulas, and the quadratic and combined quadratic formulas. We calculated the adjusted r-square (r2) in relation to iGFR and tested the improvement in variance explained by means of the likelihood ratio test. The combined Schwartz and the combined quadratic formulas yielded best results with an r2 of 0.676 and 0.730, respectively. The addition of BNP and PTH to the combined Schwartz and quadratic formulas improved the variance slightly. NGAL and albumin failed to improve the prediction of GFR further. These study results also confirm that the addition of cystatin C improves the performance of estimating GFR formulas, in particular the Schwartz formula.Conclusion: The addition of serum NGAL, BNP, PTH, and albumin to the combined Schwartz and quadratic formulas for estimating GFR did not improve GFR prediction in our population. What is Known:• Estimating glomerular filtration rate (GFR) formulas include serum creatinine and/or cystatin C but lack precision when compared to measured GFR.• The serum concentrations of some biological parameters such as neutrophil gelatinase-associated lipocalin (NGAL), parathyroid hormone (PTH), albumin, and brain natriuretic peptide (BNP) vary with the level of renal function. What is New:• The addition of BNP and PTH to the combined quadratic formula improved its performance only slightly. NGAL and albumin failed to improve the prediction of GFR further.

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Comparison of estimated GFR equations based on serum cystatin C alone and in combination with serum creatinine in patients with coronary artery disease

The Anatolian Journal of Cardiology ◽

10.5152/akd.2014.5535 ◽

2015 ◽

Vol 15 (7) ◽

pp. 571-576 ◽

Cited By ~ 6

Author(s):

Yusuf Cetin Doganer ◽

Umit Aydogan ◽

James Edwin Rohrer ◽

Aydogan Aydogdu ◽

Tuncer Cayci ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Serum Creatinine ◽

Cystatin C ◽

Serum Cystatin C ◽

Estimated Gfr ◽

Serum Cystatin ◽

Artery Disease

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Comparative Study of Significance of Serum Cystatin-C, Serum Creatinine and Microalbuminuria Estimation in Patients of Early Diabetic Nephropathy

Journal of Diabetes & Metabolism ◽

10.4172/2155-6156.1000490 ◽

2015 ◽

Vol 06 (02) ◽

Author(s):

Mukherjee Brijesh Patra Saurav

Keyword(s):

Diabetic Nephropathy ◽

Serum Creatinine ◽

Comparative Study ◽

Cystatin C ◽

Serum Cystatin C ◽

Serum Cystatin ◽

Early Diabetic Nephropathy

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The Ratio Serum Creatinine/Serum Cystatin C (a Surrogate Marker of Muscle Mass) as a Predictor of Hospitalization in Chronic Obstructive Pulmonary Disease Outpatients

Respiration ◽

10.1159/000494296 ◽

2018 ◽

Vol 97 (4) ◽

pp. 302-309 ◽

Cited By ~ 12

Author(s):

Carlos Antonio Amado ◽

Maria Teresa García-Unzueta ◽

Bernardo Alio Lavin ◽

Armando Raúl Guerra ◽

Juan Agüero ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Serum Creatinine ◽

Pulmonary Disease ◽

Muscle Mass ◽

Cystatin C ◽

Surrogate Marker ◽

Chronic Obstructive ◽

Serum Cystatin C ◽

Serum Cystatin ◽

Obstructive Pulmonary Disease

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The serum creatinine to cystatin C ratio predicts bone fracture in patients with type 2 diabetes: The Fukuoka Diabetes Registry

Diabetes Research and Clinical Practice ◽

10.1016/j.diabres.2018.10.021 ◽

2018 ◽

Vol 146 ◽

pp. 202-210 ◽

Cited By ~ 5

Author(s):

Yuji Komorita ◽

Masanori Iwase ◽

Hiroki Fujii ◽

Hitoshi Ide ◽

Toshiaki Ohkuma ◽

...

Keyword(s):

Type 2 Diabetes ◽

Serum Creatinine ◽

Cystatin C ◽

Bone Fracture ◽

Diabetes Registry

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GW28-e0340 A novel simple experimental model for low-osmolar contrast-induced acute kidney injury using different definitions based on the levels of serum creatinine and cystatin C

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2017.07.025 ◽

2017 ◽

Vol 70 (16) ◽

pp. C7

Author(s):

Yuanhui Liu ◽

Ning Tan ◽

Yong Liu ◽

Jiyan Chen

Keyword(s):

Acute Kidney Injury ◽

Serum Creatinine ◽

Experimental Model ◽

Cystatin C ◽

Kidney Injury

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New Biomarkers for the Quick Detection of Acute Kidney Injury

ISRN Nephrology ◽

10.5402/2013/394582 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 19

Author(s):

Abdulmuttalip Simsek ◽

Volkan Tugcu ◽

Ali Ihsan Tasci

Keyword(s):

Acute Kidney Injury ◽

Serum Creatinine ◽

Critically Ill ◽

Cystatin C ◽

Critically Ill Patients ◽

Clinical Training ◽

Kidney Injury ◽

Urinary Proteins ◽

New Biomarkers ◽

Urine And Serum

Acute kidney injury (AKI) is a common and strong problem in the diagnosis of which based on measurement of BUN and serum creatinine. These traditional methods are not sensitive and specific for the diagnosis of AKI. AKI is associated with increased morbidity and mortality in critically ill patients and a quick detection is impossible with BUN and serum creatinine. A number of serum and urinary proteins have been identified that may messenger AKI prior to a rise in BUN and serum creatinine. New biomarkers of AKI, including NGAL, KIM-1, cystatin-C, IL-18, and L-FABP, are more favourable tests than creatinine which have been identified and studied in several experimental and clinical training. This paper will discuss some of these new biomarkers and their potential as useful signs of AKI. We searched the literature using PubMed and MEDLINE with acute kidney injury, urine, and serum new biomarkers and the articles were selected only from publication types in English.

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Sarcopenia index based on serum creatinine and cystatin C predicts the risk of postoperative complications following hip fracture surgery in older adults

BMC Geriatrics ◽

10.1186/s12877-021-02522-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Xiaoyan Chen ◽

Yanjiao Shen ◽

Lisha Hou ◽

Binyu Yang ◽

Birong Dong ◽

...

Keyword(s):

Older Adults ◽

Hip Fracture ◽

Postoperative Complications ◽

Serum Creatinine ◽

Cystatin C ◽

Binary Logistic Regression ◽

Joint Replacement Surgery ◽

Hip Fracture Surgery ◽

Replacement Surgery ◽

Fracture Surgery

Abstract Objective To assess the utility of the preoperative Sarcopenia index (SI) as a predictive marker of the risk of postoperative complications following hip fracture surgery in older adults. Study design This observational study enrolled older adults with hip fracture who were hospitalized in the Department of Orthopedics of West China Hospital, Sichuan University, from December 7, 2010 - June 14, 2017, and who underwent hip fracture surgery. Primary outcome and measures Clinical data were collected from medical records and serum creatinine and cystatin C were measured before surgery. Outcomes included postoperative complications such as pneumonia, urinary tract infection, respiratory failure, heart failure, and non-grade A healing. Binary logistic regression analyses were used to analyze association between SI and postoperative complications. Results A total of 897 patients aged 60 years and over were enrolled in this study (age range: 60 – 100 years), of whom 306(34.1%)were male, and 591(65.9%)were female. Postoperative complications included pneumonia (12%), urinary tract infections (1.8%), respiratory failure (1.5%), heart failure (1.6%), and non-A- grade healing (3.6%). In the patient group that received joint replacements, the incidence of pneumonia was negatively associated with SI values. After adjusting for potential confounding factors, binary logistic regression analyses showed that a higher SI was independently associated with a lower risk of pneumonia after joint replacement surgery (OR:0.39, 95% CI:0.18-0.89, P<0.05). However, we did not find statistically significant association between SI and the risk of postoperative complications other than pneumonia among patients with two types of hip fracture surgery. Conclusion The SI based on serum creatinine and cystatin C can predict pneumonia rather than other postoperative complications among older patients with hip fracture after joint replacement surgery.

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