scholarly journals Do bisphosphonates reduce early micromotion and Periprosthetic bone loss in total knee arthroplasty? A review of the evidence

2006 ◽  
Vol 7 (4) ◽  
pp. 201-206
Author(s):  
V. Calvisi ◽  
S. Lupparelli ◽  
R. Padua
Keyword(s):  
Total Knee Arthroplasty ◽  
Bone Loss ◽  
Knee Arthroplasty ◽  
Periprosthetic Bone ◽  
Periprosthetic Bone Loss ◽  
Total Knee

scholarly journals Denosumab might prevent periprosthetic bone loss after total hip and knee arthroplasties: a review

Arthroplasty ◽  
2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Jianda Xu ◽  
Huan Li ◽  
Yuxing Qu ◽  
Chong Zheng ◽  
Bin Wang ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Total Hip Arthroplasty ◽  
Bone Loss ◽  
Knee Arthroplasty ◽  
Hip Arthroplasty ◽  
Current Evidence ◽  
Periprosthetic Bone ◽  
Total Hip ◽  
Periprosthetic Bone Loss ◽  
Total Knee

AbstractTotal hip arthroplasty and total knee arthroplasty are extensively used for the treatment of the end-stage degenerative joint diseases. Currently, periprosthetic bone loss is still the major cause of aseptic loosening, resulting in implant failures. Previous literature introduced some widely accepted protocols for the prevention and treatment of periprosthetic bone loss, but no guideline has been proposed. Denosumab, a human monoclonal immunoglobulin G2 (IgG2) antibody, can inhibit bone resorption by binding to the receptor activator of nuclear factor kappa-B ligand (RANKL). This article reviews the present findings and evidence concerning the effect of denosumab on the periprosthetic bone loss after total hip arthroplasty and total knee arthroplasty. Overall, the current evidence suggests that denosumab is a promising agent for the treatment of periprosthetic bone loss.

scholarly journals Modulation and Predictors of Periprosthetic Bone Mineral Density following Total Knee Arthroplasty

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Anett Mau-Moeller ◽  
Martin Behrens ◽  
Sabine Felser ◽  
Sven Bruhn ◽  
Wolfram Mittelmeier ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Total Knee Arthroplasty ◽  
Bone Loss ◽  
Muscle Mass ◽  
Knee Arthroplasty ◽  
Lean Mass ◽  
Mineral Density ◽  
Periprosthetic Bone ◽  
Periprosthetic Bone Mineral Density ◽  
Total Knee

Total knee arthroplasty (TKA) leads to a loss of periprosthetic bone mineral density (BMD). Great importance is attached to the prevention of periprosthetic bone loss with a view to ensuring a long service life of the prosthesis. In order to provide appropriate recommendations for preventive movement therapy measures to combat peri-implant bone loss, it is necessary to know the predictors of periprosthetic BMD. The aim of this study was (1) to determine the change of periprosthetic BMD of the femur and tibia and (2) to analyse the effects of different predictors on periprosthetic BMD. Twenty-three patients with primary TKA were evaluated 10 days and 3 months postoperatively. The data analysis comprised (1) the change in periprosthetic BMD from pretest to posttest and (2) the correlations between BMD and the variables isometric maximum voluntary force, lean mass, physical activity (step count), and BMI using multiple linear regression and structural equation modelling (SEM). BMD of the distal femur was significantly reduced by 19.7% (P = 0.008) 3 months after surgery, while no changes were found in BMD of the tibia. The results of SEM demonstrate that 55% of the BMD variance was explained by the model (χ2=0.002;df=1;P=0.96;χ2/df=0.002;RMSEA<0.01;TLI=1.5;CFI=1.0). A significant direct effect was only evidenced by the variable lean mass (β=0.38;b=0.15;SE=0.07;C.R.=2.0;P=0.046). It can be assumed that a large muscle mass with accompanying distribution of high mechanical load in the bones can contribute to local changes of periprosthetic BMD. Concrete recommendations for preventing peri-implant bone loss therefore include exercises which have the aim of maintaining or building up muscle mass.

THE PATHOGENESIS OF BONE LOSS FOLLOWING TOTAL KNEE ARTHROPLASTY

1998 ◽  
Vol 29 (2) ◽  
pp. 187-197 ◽  
Author(s):  
Peter L. Lewis ◽  
Nigel T. Brewster ◽  
Stephen E. Graves
Keyword(s):  
Total Knee Arthroplasty ◽  
Bone Loss ◽  
Knee Arthroplasty ◽  
Total Knee
Sign in / Sign up

Export Citation Format

Share Document