The NEK family of serine/threonine kinases as a biomarker for cancer

2022 ◽  
Author(s):  
Nagesh Kishan Panchal ◽  
Sabina Evan Prince
Keyword(s):  
Threonine Kinases

scholarly journals Receptor-mediated activation of multiple serine/threonine kinases in human leukocytes.

1993 ◽  
Vol 268 (27) ◽  
pp. 20223-20231
Author(s):  
S Grinstein ◽  
W Furuya ◽  
J.R. Butler ◽  
J Tseng
Keyword(s):  
Human Leukocytes ◽  
Threonine Kinases

The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel α,β,γ-ENaC

2003 ◽  
Vol 445 (6) ◽  
pp. 693-696 ◽  
Author(s):  
B. Friedrich ◽  
Y. Feng ◽  
P. Cohen ◽  
T. Risler ◽  
A. Vandewalle ◽  
...  
Keyword(s):  
Na Channel ◽  
Threonine Kinases ◽  
Epithelial Na Channel

scholarly journals HIV-1 protease cleaves the serine-threonine kinases RIPK1 and RIPK2

Retrovirology ◽  
2015 ◽  
Vol 12 (1) ◽  
Author(s):  
Roland N. Wagner ◽  
John C. Reed ◽  
Sumit K. Chanda
Keyword(s):  
Threonine Kinases ◽  
Hiv 1

Protein kinase cascades in meiotic and mitotic cell cycle control

1990 ◽  
Vol 68 (12) ◽  
pp. 1297-1330 ◽  
Author(s):  
Steven L. Pelech ◽  
Jasbinder S. Sanghera ◽  
Maleki Daya-Makin
Keyword(s):  
Cell Cycle ◽  
Cell Division ◽  
Protein Kinase ◽  
Tyrosine Kinases ◽  
Somatic Cells ◽  
Protein Tyrosine Kinases ◽  
Sea Star ◽  
Protein Tyrosine ◽  
Threonine Kinases ◽  
Cell Division Control

Eukaryotic cell cycle progression during meiosis and mitosis is extensively regulated by reversible protein phosphorylation. Many cell surface receptors for mitogens are ligand-stimulated protein-tyrosine kinases that control the activation of a network of cytoplasmic and nuclear protein-serine(threonine) kinases. Over 30 plasma membrane associated protein-tyrosine kinases are encoded by proto-oncogenes, i.e., genes that have the potential to facilitate cancer when disregulated. Proteins such as ribosomal protein S6, microtubule-associated protein-2, myelin basic protein, and casein have been used to detect intracellular protein-serine(threonine) kinases that are activated further downstream in growth factor signalling transduction cascades. Genetic analysis of yeast cell division control (cdc) mutants has revealed another 20 or so protein-serine(threonine) kinases. One of these, specified by the cdc-2 gene in Schizosaccharomyces pombe, has homologs that are stimulated during M phase in maturing sea star and frog oocytes and mammalian somatic cells. Furthermore, during meiotic maturation in these echinoderm and amphibian oocytes, this is followed by activation of many of the same protein-serine(threonine) kinases that are stimulated when quiescent mammalian somatic cells are prompted with mitogens to traverse from G0 to G1 phase. These findings imply that a similar protein kinase cascade may oversee progression at multiple points in the cell cycle.Key words: protein kinases, mitosis, meiosis, oncogenes, cell division control.

scholarly journals Binding of PTEN to Specific PDZ Domains Contributes to PTEN Protein Stability and Phosphorylation by Microtubule-associated Serine/Threonine Kinases

2005 ◽  
Vol 280 (32) ◽  
pp. 28936-28943 ◽  
Author(s):  
Miguel Valiente ◽  
Amparo Andrés-Pons ◽  
Beatriz Gomar ◽  
Josema Torres ◽  
Anabel Gil ◽  
...  
Keyword(s):  
Protein Stability ◽  
Pdz Domains ◽  
Pten Protein ◽  
Threonine Kinases

scholarly journals HTRF® KinEASETM: a new solution for screening serine-threonine kinases

2006 ◽  
Vol 3 (6) ◽  
pp. I-II ◽  
Author(s):  
Cathy Drexler
Keyword(s):  
Threonine Kinases

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

Cell ◽  
1991 ◽  
Vol 65 (4) ◽  
pp. 663-675 ◽  
Author(s):  
Teri G. Boulton ◽  
Steven H. Nye ◽  
David J. Robbins ◽  
Nancy Y. Ip ◽  
Elizabeth Radzlejewska ◽  
...  
Keyword(s):  
Threonine Kinases
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