Model-Based Pancreas Segmentation in Portal Venous Phase Contrast-Enhanced CT Images

AbstractTo explore the value of contrast-enhanced CT texture analysis in predicting isocitrate dehydrogenase (IDH) mutation status of intrahepatic cholangiocarcinomas (ICCs). Institutional review board approved this study. Contrast-enhanced CT images of 138 ICC patients (21 with IDH mutation and 117 without IDH mutation) were retrospectively reviewed. Texture analysis was performed for each lesion and compared between ICCs with and without IDH mutation. All textural features in each phase and combinations of textural features (p < 0.05) by Mann–Whitney U tests were separately used to train multiple support vector machine (SVM) classifiers. The classification generalizability and performance were evaluated using a tenfold cross-validation scheme. Among plain, arterial phase (AP), portal venous phase (VP), equilibrium phase (EP) and Sig classifiers, VP classifier showed the highest accuracy of 0.863 (sensitivity, 0.727; specificity, 0.885), with a mean area under the receiver operating characteristic curve of 0.813 in predicting IDH mutation in validation cohort. Texture features of CT images in portal venous phase could predict IDH mutation status of ICCs with SVM classifier preoperatively.

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Distinction of Renal Cell Carcinomas from High-Attenuation Renal Cysts at Portal Venous Phase Contrast-enhanced CT

Radiology ◽

10.1148/radiol.2282020922 ◽

2003 ◽

Vol 228 (2) ◽

pp. 330-334 ◽

Cited By ~ 44

Author(s):

Michael Suh ◽

Fergus V. Coakley ◽

Aliya Qayyum ◽

Benjamin M. Yeh ◽

Richard S. Breiman ◽

...

Keyword(s):

Renal Cell ◽

Phase Contrast ◽

Renal Cysts ◽

Renal Cell Carcinomas ◽

Portal Venous Phase ◽

High Attenuation ◽

Contrast Enhanced Ct ◽

Contrast Enhanced ◽

Enhanced Ct ◽

Venous Phase

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Detecting hepatocellular carcinoma: value of unenhanced or arterial phase CT imaging or both used in conjunction with conventional portal venous phase contrast-enhanced CT imaging.

American Journal of Roentgenology ◽

10.2214/ajr.167.1.8659425 ◽

1996 ◽

Vol 167 (1) ◽

pp. 71-77 ◽

Cited By ~ 113

Author(s):

J H Oliver ◽

R L Baron ◽

M P Federle ◽

H E Rockette

Keyword(s):

Hepatocellular Carcinoma ◽

Phase Contrast ◽

Ct Imaging ◽

Arterial Phase ◽

Portal Venous Phase ◽

Contrast Enhanced Ct ◽

Contrast Enhanced ◽

Enhanced Ct ◽

Venous Phase

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Renal stones on portal venous phase contrast-enhanced CT: does intravenous contrast interfere with detection?

Abdominal Imaging ◽

10.1007/s00261-014-0082-4 ◽

2014 ◽

Vol 39 (3) ◽

pp. 526-532 ◽

Cited By ~ 11

Author(s):

R. Joshua Dym ◽

Dameon R. Duncan ◽

Michael Spektor ◽

Hillel W. Cohen ◽

Meir H. Scheinfeld

Keyword(s):

Phase Contrast ◽

Renal Stones ◽

Intravenous Contrast ◽

Portal Venous Phase ◽

Contrast Enhanced Ct ◽

Contrast Enhanced ◽

Enhanced Ct ◽

Venous Phase

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Retrospective evaluation of venous phase contrast-enhanced computed tomography images in patients who developed pancreatic adenocarcinomas after treatment for nonpancreatic primary cancer

BJR|Open ◽

10.1259/bjro.20200069 ◽

2021 ◽

pp. 20200069

Author(s):

Ryo Takaji ◽

Yasunari Yamada ◽

Ryuichi Shimada ◽

Shunro Matsumoto ◽

Tsutomu Daa ◽

...

Keyword(s):

Pancreatic Adenocarcinoma ◽

Phase Contrast ◽

Ct Images ◽

Pancreatic Cancers ◽

Ct Findings ◽

Contrast Enhanced Ct ◽

Contrast Enhanced ◽

Enhanced Ct ◽

Venous Phase

Objectives: To clarify venous phase contrast-enhanced CT findings in early pancreatic adenocarcinomas by retrospectively evaluating CT images of pancreatic adenocarcinomas that developed during follow-up after treatment for non-pancreatic cancers. Methods: The study cohort comprised six patients who developed pancreatic adenocarcinomas between April 2005 and April 2020 during follow-up after treatment for non-pancreatic primary cancers. Two radiologists retrospectively evaluated CT images and reached consensus on previously reported CT findings that were suggestive of small pancreatic adenocarcinomas; namely pancreatic duct interruption and dilatation, pancreatic parenchymal atrophy, focal hypoattenuated areas, and appearance of cystic lesions. Time intervals between the first CT with these suggestive findings and the latest pre-operative CT were recorded. Doubling times were calculated in patients with hypoattenuated areas on initial CT scans. Results: Small (<10 mm) focal hypoattenuated areas with (n = 2) or without rim enhancement (n = 1) were identified on initial CT images of three patients. Pancreatic duct interruption and dilatation, pancreatic parenchymal atrophy, and cystic lesion were identified in two, one and one patient, respectively. Time intervals between initial and latest preoperative CT examination were 6–19 months (median, 14.5 months). Tumor doubling time according to CT findings was calculated as 46–407 days (median 106 days). Conclusion: Venous phase contrast-enhanced CT can provide findings that are suggestive of early pancreatic adenocarcinoma. Pancreatic phase contrast-enhanced CT should therefore be performed in patients with such findings with the aim of early detection of pancreatic adenocarcinoma. Advances in knowledge: Pancreatic adenocarcinoma can develop subsequently in patients with non-pancreatic malignancies. Patients with non-pancreatic cancers are often followed up with monophasic contrast-enhanced CT in venous phase timing. Venous phase contrast-enhanced CT can provide some findings suggestive of early pancreatic adenocarcinoma. Knowledge of these findings is important for early detection of pancreatic adenocarcinoma.

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Successful staged management of a spontaneous iliac vein rupture associated with May-Thurner syndrome: a case report

European Heart Journal - Case Reports ◽

10.1093/ehjcr/ytab316 ◽

2021 ◽

Author(s):

Yuji Nishimoto ◽

Masanao Toma ◽

Kohei Iwasa ◽

Yukihito Sato

Keyword(s):

Conservative Management ◽

Lower Limb ◽

Phase Contrast ◽

Anticoagulation Therapy ◽

Iliac Vein ◽

Ivc Filter ◽

Contrast Enhanced Ct ◽

Contrast Enhanced ◽

Enhanced Ct ◽

Venous Phase

Abstract Background Spontaneous iliac vein ruptures have only been reported in approximately 50 cases. An accurate preoperative diagnosis is difficult even with contrast-enhanced computed tomography (CT), and the operative mortality and morbidity rates are quite high. The cause of spontaneous iliac vein ruptures and their optimal diagnosis and management remain unclear. Case Summary A 69-year-old woman without a history of prior trauma presented with low back pain, left lower limb swelling, and hypovolemic shock. An initial contrast-enhanced CT revealed a large retroperitoneal hematoma without arterial extravasation. Her blood pressure dropped again under a noradrenaline administration. A second venous phase contrast-enhanced CT revealed venous extravasation in the external iliac vein with a suspected compression of the common iliac vein (May-Thurner syndrome) and deep vein thrombosis (DVT). Her haemodynamics were stabilised whilst a laparotomy was arranged. An inferior vena cava (IVC) filter was placed due to concerns about rebleeding with initiating anticoagulation therapy. Given the failed conservative management, elective endovascular treatment (EVT) was performed including percutaneous Fogarty venous thrombectomy and placement of self-expanding and covered stents. After the intervention, the lower limb swelling significantly improved under oral anticoagulation therapy, and the IVC filter was retrieved. At the 3-month follow-up, the lower limb swelling completely disappeared, and the contrast-enhanced CT demonstrated the complete disappearance of the retroperitoneal hematoma and DVT. Discussion This case provided not only the potential value of the venous phase contrast-enhanced CT in diagnosing a spontaneous iliac vein rupture, but also the potential benefit of conservative management followed by elective EVT.

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