scholarly journals Impact of combination MMRV vaccine on first-dose coverage for measles and varicella: a population-based study

2020 ◽  
Author(s):  
Shannon E. MacDonald ◽  
Suzanne Tough ◽  
Xiaoyan Guo ◽  
James D. Kellner
Keyword(s):  
Vaccine Coverage ◽  
Varicella Vaccine ◽  
Population Based ◽  
Combination Vaccine ◽  
Population Based Study ◽  
Vaccine Introduction ◽  
Opt Out ◽  
Combination Vaccines ◽  
Before And After ◽  
To Receive

Abstract Aim Combination vaccines decrease the number of needles required, addressing a common concern of parents. However, some parents are hesitant about combination vaccines and/or want to opt out of certain vaccine components. This study assessed whether introduction of the combination MMRV vaccine influenced coverage levels for measles- and varicella-containing vaccines. Study and methods This was a population-based study of children born in Alberta, Canada between 2006 and 2012. We utilized administrative health data to evaluate coverage for the first dose of measles- and varicella-containing vaccines at the age of 24 months (i.e. between 2008 and 2014) before and after introduction of the combination MMRV vaccine in 2010. Among those who were vaccinated, we assessed whether any children continued to receive separate vaccines after the combination vaccine was introduced. Results Of 308,212 children, 272,345 (88.36%) were vaccinated with measles- and/or varicella-containing vaccines at the age of 24 months. Although coverage for measles-containing vaccines did not change overall between 2008 and 2014, coverage for varicella vaccine increased in the years following the introduction of MMRV. After the combination vaccine introduction, 96.55% of vaccinated children (n = 121,131) received MMRV vaccine. Conclusion Vaccine coverage for varicella increased after the introduction of the combination MMRV vaccine, and there was a narrowing in the gap between MMR and varicella coverage. Very few children received separate vaccines after the introduction of the combination MMRV vaccine. These findings suggest that combination vaccines are acceptable to most parents and increase coverage for varicella in our setting.

scholarly journals Trends in Diagnosis‐Specific Work Disability Before and After Stroke: A Longitudinal Population‐Based Study in Sweden

2018 ◽  
Vol 7 (1) ◽  
Author(s):  
Tea Lallukka ◽  
Jenni Ervasti ◽  
Erik Lundström ◽  
Ellenor Mittendorfer‐Rutz ◽  
Emilie Friberg ◽  
...  
Keyword(s):  
Work Disability ◽  
Population Based ◽  
Specific Work ◽  
Population Based Study ◽  
Before And After

scholarly journals A 10-Year Population Based Study of ‘Opt-Out’ HIV Testing of Tuberculosis Patients in Alberta, Canada: National Implications

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e98993 ◽  
Author(s):  
Richard Long ◽  
Selvanayagam Niruban ◽  
Courtney Heffernan ◽  
Ryan Cooper ◽  
Dina Fisher ◽  
...  
Keyword(s):  
Hiv Testing ◽  
Population Based ◽  
Population Based Study ◽  
Tuberculosis Patients ◽  
Opt Out

scholarly journals Chronic Viral Hepatitis Signifies the Association of Premixed Insulin Analogues with Liver Cancer Risks: A Nationwide Population-Based Study

2019 ◽  
Vol 16 (12) ◽  
pp. 2097 ◽  
Author(s):  
Chien-Hsieh Chiang ◽  
Chia-Sheng Kuo ◽  
Wan-Wan Lin ◽  
Jun-Han Su ◽  
Jin-De Chen ◽  
...  
Keyword(s):  
Viral Hepatitis ◽  
Population Based ◽  
Insulin Analogues ◽  
Chronic Viral Hepatitis ◽  
Premixed Insulin ◽  
Population Based Study ◽  
Before And After ◽  
Nested Case Control

This study sought to determine whether chronic hepatitis B or C would modify the association between insulin analogues and hepatocellular carcinoma (HCC) risks. We conducted a nationwide nested case-control study for HCC cases and matched controls from 2003 to 2013 among newly diagnosed type 2 diabetes patients on any antidiabetic agents in Taiwan before and after exclusion of chronic viral hepatitis, respectively. A total of 5832 and 1237 HCC cases were identified before and after exclusion of chronic viral hepatitis, respectively. Incident HCC risks were positively associated with any use of premixed insulin analogues (adjusted odds ratio (OR), 1.27; 95% CI 1.04 to 1.55) among total participants, especially among current users (adjusted OR, 1.45; 95% CI 1.12 to 1.89). However, the association between HCC occurrence and premixed insulin analogues diminished among participants without chronic viral hepatitis (adjusted OR, 1.35; 95% CI 0.92 to 1.98). We also observed a significant multiplicative interaction between chronic viral hepatitis and premixed insulin analogues on HCC risks (P = 0.010). Conclusions: Chronic viral hepatitis signifies the role of premixed insulin analogues in HCC oncogenesis. We recommend a closer liver surveillance among patients prescribed premixed insulin analogues with concomitant chronic viral hepatitis.

scholarly journals Seawater desalination and serum magnesium concentrations in Israel

2016 ◽  
Vol 15 (2) ◽  
pp. 296-299 ◽  
Author(s):  
Gideon Koren ◽  
Meital Shlezinger ◽  
Rachel Katz ◽  
Varda Shalev ◽  
Yona Amitai
Keyword(s):  
Serum Magnesium ◽  
Large Population ◽  
Population Based ◽  
Morbidity And Mortality ◽  
Population Based Study ◽  
Cardiac Morbidity ◽  
Before And After ◽  
The Mean ◽  
Magnesium Status ◽  
The Impact

With increasing shortage of fresh water globally, more countries are consuming desalinated seawater (DSW). In Israel >50% of drinking water is now derived from DSW. Desalination removes magnesium, and hypomagnesaemia has been associated with increased cardiac morbidity and mortality. Presently the impact of consuming DSW on body magnesium status has not been established. We quantified changes in serum magnesium in a large population based study (n = 66,764), before and after desalination in regions consuming DSW and in regions where DSW has not been used. In the communities that switched to DSW in 2013, the mean serum magnesium was 2.065 ± 0.19 mg/dl before desalination and fell to 2.057 ± 0.19 mg/dl thereafter (p < 0.0001). In these communities 1.62% of subjects exhibited serum magnesium concentrations ≤1.6 mg/dl between 2010 and 2013. This proportion increased by 24% between 2010–2013 and 2015–2016 to 2.01% (p = 0.0019). In contrast, no such changes were recorded in the communities that did not consume DSW. Due to the emerging evidence of increased cardiac morbidity and mortality associated with hypomagnesaemia, it is vital to consider re-introduction of magnesium to DSW.

Utilization of inpatient care before and after hip fracture: a population-based study

2008 ◽  
Vol 20 (6) ◽  
pp. 879-886 ◽  
Author(s):  
E. Lönnroos ◽  
H. Kautiainen ◽  
R. Sund ◽  
P. Karppi ◽  
S. Hartikainen ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Inpatient Care ◽  
Population Based ◽  
Population Based Study ◽  
Before And After

scholarly journals Diarrheal Diseases Hospitalization in Yemen before and after Rotavirus Vaccination

Scientifica ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Mohammed Amood AL-Kamarany ◽  
Lina Al-Areqi ◽  
Abulatif Mujally ◽  
Fawzya Alkarshy ◽  
Arwa Nasser ◽  
...  
Keyword(s):  
Vaccine Coverage ◽  
Rotavirus Vaccine ◽  
Diarrheal Diseases ◽  
Predominant Genotype ◽  
Fecal Samples ◽  
Vaccine Introduction ◽  
Rotavirus Vaccination ◽  
Before And After ◽  
Rotavirus Diarrhea ◽  
The Impact

The study aims to assess the impact of rotavirus vaccine introduction on diarrheal diseases hospitalization and to identify the rotavirus genotypes most prevalent before and after vaccine introduction among children ≤ 5 years of age. Rotarix™® rotavirus vaccine is currently licensed for infants in Yemen and was introduced in 2012. The vaccination course consists of two doses. The first dose is administrated at 6 weeks of age and the second dose is completed by 10 weeks. Based on a longitudinal observational study, we assessed the impact of vaccination on rotavirus hospitalization before and after vaccination among children ≤ 5 years of age at the Yemeni-Swedish Hospital (YSH) in Taiz, Yemen. Prevaccination covered January 2009–July 2012 during which 2335 fecal samples were collected from children ≤ 5 years old. Postvaccination covered January 2013–December 2014 during which 1114 fecal samples were collected. Rotavirus was detected by Enzyme Linkage Immunosorbent Assay (ELISA). The incidence ofrotavirushospitalization decreased from 43.79% in 2009 to 10.54% in 2014. Hospitalization due to rotavirus diarrhea was reduced by 75.93%. Vaccine coverage increased from 23% in 2012 to 72% in 2014. Also, the results showed that the most predominant genotypes in prevaccination period were G2P[4] (55.0%), followed by G1P[8] (15.0%), while in postvaccination period G1P[8] (31%) was the predominant genotype, followed by G9P[8] (27.5%). In conclusion, rotavirus vaccination in Yemen resulted in sharp reduction in diarrheal hospitalization. A successful rotavirus vaccination program in Yemen will rely upon efficient vaccine delivery systems and sustained vaccine efficacy against diverse and evolving rotavirus strains.

scholarly journals PD45-02 OPIOID USE BEFORE AND AFTER RADICAL PROSTATECTOMY: NATIONWIDE POPULATION-BASED STUDY

2019 ◽  
Vol 201 (Supplement 4) ◽  
Author(s):  
Walter Cazzaniga* ◽  
Stacy Loeb ◽  
Hans Garmo ◽  
David Robinson ◽  
Pär Stattin
Keyword(s):  
Radical Prostatectomy ◽  
Population Based ◽  
Opioid Use ◽  
Population Based Study ◽  
Before And After

scholarly journals Intention to receive a COVID-19 vaccine: Results from a population-based survey in Canada

2021 ◽  
Author(s):  
Gina S. Ogilvie ◽  
Shanlea Gordon ◽  
Laurie W. Smith ◽  
Arianne Albert ◽  
C. Sarai Racey ◽  
...  
Keyword(s):  
Social Norms ◽  
Online Survey ◽  
Vaccine Coverage ◽  
Vaccine Safety ◽  
Population Based ◽  
Vaccine Uptake ◽  
Older Individuals ◽  
Theoretical Frameworks ◽  
Logistic Regression Models ◽  
To Receive

AbstractObjectiveThe success of any COVID-19 vaccine program ultimately depends on high vaccine uptake. This study determined overall intention to receive a COVID-19 vaccine and identified factors that predict intentions to be vaccinated against COVID-19 in Canada.MethodsIndividuals from research cohorts from the general population of British Columbia aged 25-69 were invited complete an online survey based on validated scales and theoretical frameworks to explore intention to receive a COVID-19 vaccine. Two multivariable logistic regression models were conducted to determine factors associated with intention to receive the COVID-19 vaccine.ResultsOf 4,528 respondents, 79.8% intended to receive a COVID-19 vaccine. In multivariable modeling, respondents who intended to receive the vaccine had higher vaccine attitudinal scores (p <0.001), reported greater influence of direct social norms (p = 0.001), and indirect social norms, including their family physician (p = 0.024), and Provincial Health Officer (p = 0.011). Older individuals (>60 years) were more likely to intend to receive the vaccine, while females (95%CI 0.57,0.93), those with less than high school education (95%CI 0.5,0.76), those who self-identified as non-white (95%CI 0.60,0.92), self-identified as Indigenous (95%CI 0.36,0.84) and essential non-health care workers (95%CI 0.59,0.86) had lower adjusted odds of intending to receive a COVID-19 vaccine.ConclusionsTo optimize vaccine coverage, public health should focus on key messages around vaccine safety and benefit, and leverage trusted practitioners for messaging. As certain key populations report a lower intention to vaccinate, there is a need for in-depth education and support for these communities to ensure optimal uptake.

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