Hepatic parenchymal hemodynamics of cholangitis with portal trunk thrombus using contrast-enhanced ultrasonography with Sonazoid: delineation of so-called central and peripheral zonal differentiation by arrival-time parametric imaging

2012 ◽  
Vol 40 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Kazue Shiozawa ◽  
Manabu Watanabe ◽  
Ryuji Takayama ◽  
Takahide Kudo ◽  
Kenichi Maruyama ◽  
...  
Keyword(s):  
Arrival Time ◽  
Parametric Imaging ◽  
Contrast Enhanced ◽  
Arrival Time Parametric Imaging ◽  
Contrast Enhanced Ultrasonography ◽  
Portal Trunk ◽  
Zonal Differentiation

scholarly journals Evaluation of sorafenib for hepatocellular carcinoma by arrival time parametric imaging using contrast-enhanced ultrasonography with Sonazoid

Kanzo ◽  
2013 ◽  
Vol 54 (5) ◽  
pp. 363-366
Author(s):  
Kazue Shiozawa ◽  
Manabu Watanabe ◽  
Takashi Ikehara ◽  
Yasushi Matsukiyo ◽  
Masahiro Kanayama ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Arrival Time ◽  
Parametric Imaging ◽  
Contrast Enhanced ◽  
Arrival Time Parametric Imaging ◽  
Contrast Enhanced Ultrasonography

scholarly journals Arrival-Time Parametric Imaging in Contrast-Enhanced Ultrasound for Diagnosing Fibrosis in Primary Biliary Cholangitis

2021 ◽  
Author(s):  
Naoyuki Yoshimine ◽  
Noritaka Wakui ◽  
Hidenari Nagai ◽  
Yoshinori Igarashi
Keyword(s):  
Liver Biopsy ◽  
Shear Wave ◽  
Arrival Time ◽  
Characteristic Curve ◽  
Shear Wave Elastography ◽  
Disease Stage ◽  
Primary Biliary Cholangitis ◽  
Parametric Imaging ◽  
Contrast Enhanced ◽  
Arrival Time Parametric Imaging

Abstract Background: To investigate arrival-time parametric imaging (At-PI) in contrast-enhanced ultrasonography (CEUS) for diagnosing fibrosis in primary biliary cholangitis (PBC). Methods: Participants were 48 patients (male/female: 8/40; mean age, 60 ± 13 years) with PBC diagnosed by liver biopsy who underwent CEUS during 2009-2019. Of these, 27 (male/female: 4/23; mean age, 61 ± 13 years) who also underwent shear wave elastography (SWE) were further analyzed. SonazoidTM was intravenously injected and CEUS performed. Contrast dynamics of hepatic segment V and the right kidney were recorded. At-PI were generated from the recorded video clips. Contrast arrival time <5 s was displayed in red, and the ratio of red (ROR) area to the entire liver contrast-enhanced area was calculated. ROR and shear wave velocity (Vs) measured by SWE were compared by fibrosis stage (F0-F3), bile duct loss score, cholangitis activity, hepatitis activity (HA0-HA3), and disease stage (stage 1-4), as determined by liver biopsy.Results: ROR significantly differed between F0 and F2-F3 and between F1 and F2-3. Using ROR to diagnose ³F1 (³F2), area under the receiver operating characteristic curve (AUROC) was 0.77 (0.92) (cutoff, 36.7% [47.1%]; sensitivity, 0.75 [0.92]; specificity, 0.82 [0.81]). Vs significantly differed between F0 and F1, F0 and F2-3, and HA0 and HA1. For diagnosing ³F1 (³F2), Vs had AUROC of 0.84 (0.80) (cutoff, 1.23 m/s [1.40 m/s]; sensitivity, 0.75 [0.60]; specificity, 0.82 [0.86]).Conclusions: At-PI was useful for diagnosing fibrosis, especially F2 or worse, in PBC, suggesting that At-PI can correctly diagnose fibrosis regardless of hepatic inflammation.

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