Mechanosensitive Channels in the Lateral Wall Can Enhance the Cochlear Outer Hair Cell Frequency Response

2005 ◽  
Vol 33 (8) ◽  
pp. 991-1002 ◽  
Author(s):  
Alexander A. Spector ◽  
Aleksander S. Popel ◽  
Ruth Anne Eatock ◽  
William E. Brownell
Keyword(s):  
Hair Cell ◽  
Frequency Response ◽  
Outer Hair Cell ◽  
Lateral Wall ◽  
Mechanosensitive Channels ◽  
Cell Frequency

Modeling the Mechanics of Tethers Pulled From the Cochlear Outer Hair Cell Membrane

2008 ◽  
Vol 130 (3) ◽  
Author(s):  
Kristopher R. Schumacher ◽  
Aleksander S. Popel ◽  
Bahman Anvari ◽  
William E. Brownell ◽  
Alexander A. Spector
Keyword(s):  
Cell Membrane ◽  
Hair Cell ◽  
Outer Hair Cell ◽  
Lateral Wall ◽  
Outer Hair Cells ◽  
The Body ◽  
Computational Method ◽  
Membrane Properties ◽  
Bending Modulus ◽  
Sound Amplification

Cell membrane tethers are formed naturally (e.g., in leukocyte rolling) and experimentally to probe membrane properties. In cochlear outer hair cells, the plasma membrane is part of the trilayer lateral wall, where the membrane is attached to the cytoskeleton by a system of radial pillars. The mechanics of these cells is important to the sound amplification and frequency selectivity of the ear. We present a modeling study to simulate the membrane deflection, bending, and interaction with the cytoskeleton in the outer hair cell tether pulling experiment. In our analysis, three regions of the membrane are considered: the body of a cylindrical tether, the area where the membrane is attached and interacts with the cytoskeleton, and the transition region between the two. By using a computational method, we found the shape of the membrane in all three regions over a range of tether lengths and forces observed in experiments. We also analyze the effects of biophysical properties of the membrane, including the bending modulus and the forces of the membrane adhesion to the cytoskeleton. The model’s results provide a better understanding of the mechanics of tethers pulled from cell membranes.

scholarly journals Fluorescence-Imaged Microdeformation of the Outer Hair Cell Lateral Wall

1998 ◽  
Vol 18 (1) ◽  
pp. 48-58 ◽  
Author(s):  
John S. Oghalai ◽  
Alpen A. Patel ◽  
Takashi Nakagawa ◽  
William E. Brownell
Keyword(s):  
Hair Cell ◽  
Outer Hair Cell ◽  
Lateral Wall

F-0911 Ultrastructure and Mechanical Properties of the Outer Hair Cell Lateral Wall

2001 ◽  
Vol VI.01.1 (0) ◽  
pp. 181-182
Author(s):  
Hiroto USUKURA ◽  
Michiko SUGAWARA ◽  
Hiroshi WADA
Keyword(s):  
Mechanical Properties ◽  
Hair Cell ◽  
Outer Hair Cell ◽  
Lateral Wall

Salicylate induced changes in outer hair cell lateral wall stiffness

1999 ◽  
Vol 135 (1-2) ◽  
pp. 163-168 ◽  
Author(s):  
Allen Jung-Chen Lue ◽  
William E Brownell
Keyword(s):  
Hair Cell ◽  
Outer Hair Cell ◽  
Lateral Wall ◽  
Wall Stiffness ◽  
Induced Changes

Cholesterol partitioning within the outer hair cell lateral wall*

1997 ◽  
Vol 117 (2) ◽  
pp. P91-P91
Author(s):  
J OGHALAI ◽  
T NAKAGAWA ◽  
A PATEL ◽  
W BROWNELL
Keyword(s):  
Hair Cell ◽  
Outer Hair Cell ◽  
Lateral Wall

Stretch sensitivity of the lateral wall of the auditory outer hair cell from the guinea pig

1991 ◽  
Vol 133 (2) ◽  
pp. 171-174 ◽  
Author(s):  
K.H. Iwasa ◽  
Minxu Li ◽  
Min Jia ◽  
B. Kachar
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Outer Hair Cell ◽  
Lateral Wall ◽  
Stretch Sensitivity
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