DT-MRI Based Computation of Collagen Fiber Deformation in Human Articular Cartilage: A Feasibility Study

2010 ◽  
Vol 38 (7) ◽  
pp. 2447-2463 ◽  
Author(s):  
David M. Pierce ◽  
Werner Trobin ◽  
José G. Raya ◽  
Siegfried Trattnig ◽  
Horst Bischof ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Feasibility Study ◽  
Collagen Fiber ◽  
Human Articular Cartilage ◽  
Fiber Deformation

DT-MRI Based Numerical Simulation of Collagen Fiber Deformation in Human Articular Cartilage

2009 ◽  
Author(s):  
David M. Pierce ◽  
Werner Trobin ◽  
Siegfried Trattnig ◽  
Horst Bischof ◽  
Gerhard A. Holzapfel
Keyword(s):  
Articular Cartilage ◽  
Collagen Fiber ◽  
Solid Phase ◽  
Articular Surface ◽  
Type Ii Collagen ◽  
Collagen Fibers ◽  
Human Articular Cartilage ◽  
Fiber Deformation ◽  
Strength And Stiffness ◽  
High Level

Within the articular cartilage (composed of fluid, electrolytes, chondrocytes, collagen fibers, proteoglycans and other glycoproteins) fibers of predominantly Type II collagen provide tensile strength and stiffness to the solid phase, a proteoglycan gel. Collagen fibers exhibit a high level of structural organization usually consisting of three sub-tissue zones: (i) a superficial tangent zone with fibers which are tangential to the articular surface, (ii) a middle zone with fibers isotropically oriented, (iii) a deep zone with fibers oriented perpendicular to the subchondral bone [1]. Given the importance of this collagen fiber fabric in the mechanical properties of articular cartilage, many destructive and nondestructive experimental methods have been pursued to characterize fiber orientation and density.

Sodium MRI of human articular cartilage of the wrist: a feasibility study on a clinical 3T MRI scanner

2020 ◽  
Author(s):  
Anja Müller-Lutz ◽  
Benedikt Kamp ◽  
Armin M. Nagel ◽  
Alexandra Ljimani ◽  
Daniel Abrar ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Feasibility Study ◽  
Human Articular Cartilage ◽  
Sodium Mri ◽  
3T Mri

No pressure, no diamonds? - Static vs. dynamic compressive in-situ loading to evaluate human articular cartilage functionality by functional MRI

2021 ◽  
pp. 104558
Author(s):  
Daniel Truhn ◽  
Ken Tonio Zwingenberger ◽  
Justus Schock ◽  
Daniel Benjamin Abrar ◽  
Karl Ludger Radke ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Functional Mri ◽  
Human Articular Cartilage

A Review of the Collagen Orientation in the Articular Cartilage

Cartilage ◽  
2021 ◽  
pp. 194760352098877
Author(s):  
Roy D. Bloebaum ◽  
Andrew S. Wilson ◽  
William N. Martin
Keyword(s):  
Surface Layer ◽  
Articular Cartilage ◽  
Fiber Orientation ◽  
Collagen Fiber ◽  
Articular Surface ◽  
Imaging Techniques ◽  
Collagen Fibers ◽  
Deep Zone ◽  
Collagen Fiber Orientation ◽  
Critical Point Drying

Objective There has been a debate as to the alignment of the collagen fibers. Using a hand lens, Sir William Hunter demonstrated that the collagen fibers ran perpendicular and later aspects were supported by Benninghoff. Despite these 2 historical studies, modern technology has conflicting data on the collagen alignment. Design Ten mature New Zealand rabbits were used to obtain 40 condyle specimens. The specimens were passed through ascending grades of alcohol, subjected to critical point drying (CPD), and viewed in the scanning electron microscope. Specimens revealed splits from the dehydration process. When observing the fibers exposed within the opening of the splits, parallel fibers were observed to run in a radial direction, normal to the surface of the articular cartilage, radiating from the deep zone and arcading as they approach the surface layer. After these observations, the same samples were mechanically fractured and damaged by scalpel. Results The splits in the articular surface created deep fissures, exposing parallel bundles of collagen fibers, radiating from the deep zone and arcading as they approach the surface layer. On higher magnification, individual fibers were observed to run parallel to one another, traversing radially toward the surface of the articular cartilage and arcading. Mechanical fracturing and scalpel damage induced on the same specimens with the splits showed randomly oriented fibers. Conclusion Collagen fiber orientation corroborates aspects of Hunter’s findings and compliments Benninghoff. Investigators must be aware of the limits of their processing and imaging techniques in order to interpret collagen fiber orientation in cartilage.

scholarly journals Cell‐associated type I collagen in nondegenerate and degenerate human articular cartilage

2021 ◽  
Author(s):  
Katarzyna Styczynska‐Soczka ◽  
Anish K. Amin ◽  
Andrew C. Hall
Keyword(s):  
Articular Cartilage ◽  
Type I Collagen ◽  
Type I ◽  
Human Articular Cartilage
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