Because the multi-box girder bridge has many advantages, such as large torsion rigidity, large load-bearing capacity, stability, fine appearance, good applicability and convenient construction, it is widely used in China. But for the defection existing in design and construction, many box girders have serious diseases. Aiming at the diseases of a viaduct bridge, the causes of diseases are analyzed and the enforcement method is proposed in this paper. The study shows that, though the box girders have large torsion rigidity, the diaphragms are designed necessarily to enhance the transversal connection between the box girders, to make them bear the loads together, to reduce their stresses and deformation, and to reduce the stresses of deck too.