In vitro activities of plant extracts from the Brazilian Cerrado and Pantanal against Rhipicephalus (Boophilus) microplus (Acari: Ixodidae)

2013 ◽  
Vol 60 (3) ◽  
pp. 421-430 ◽  
Author(s):  
Carolina da Silva Barbosa ◽  
Ligia Miranda Ferreira Borges ◽  
José Nicácio ◽  
Reginaldo Dias Alves ◽  
Carlos Henrique Miguita ◽  
...  
2013 ◽  
Vol 60 (3) ◽  
pp. 431-431 ◽  
Author(s):  
Carolina da Silva Barbosa ◽  
Ligia Miranda Ferreira Borges ◽  
José Nicácio ◽  
Reginaldo Dias Alves ◽  
Carlos Henrique Miguita ◽  
...  

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
WR Cunha ◽  
FM Dos Santos ◽  
JA Peixoto ◽  
RCS Veneziani ◽  
AEM Crotti ◽  
...  

2011 ◽  
Vol 110 (1) ◽  
pp. 295-303 ◽  
Author(s):  
Ana Carolina de Souza Chagas ◽  
Luiz Daniel de Barros ◽  
Fernando Cotinguiba ◽  
Maysa Furlan ◽  
Rodrigo Giglioti ◽  
...  

2018 ◽  
Vol 12 (10) ◽  
pp. 106-115
Author(s):  
A. Padilla Marina ◽  
C. Simoni Isabela ◽  
Moreira H. Hoe Veronica ◽  
Judite B. Fernandes Maria ◽  
W. Arns Clarice ◽  
...  

2011 ◽  
Vol 20 (2) ◽  
pp. 89-96 ◽  
Author(s):  
Lígia Miranda Ferreira Borges ◽  
Lorena Alessandra Dias de Sousa ◽  
Carolina da Silva Barbosa

The evolution of resistance of Rhipicephalus (Boophilus) microplus to synthetic acaricides has given rise to the need for new scientific investigations on alternative ways to control this tick. In this regard, various studies on plants have been developed in an attempt to find extracts with acaricidal properties. Evaluations on plant extracts for controlling R. (B.) microplus have grown intensely over the last decade. There are many advantages from using plant extracts: for example, they can be used in organic cattle farming or even replace synthetic acaricides and they are associated with lower environmental and food contamination, slower development of resistance and lower toxicity to animals and humans. In vitro studies on plant extracts have shown promising results, but most of these extracts have not been tested on animals to validate their use. Difficulties in preparing proper formulations, differences in the chemical composition of plants of the same species due to extrinsic and intrinsic factors and sparse information on active acaricide compounds are hindrances that need to be addressed in order to enable progress within this scientific field.


2011 ◽  
Vol 20 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Ana Carolina de Souza Chagas ◽  
Cynthia Sanches Georgetti ◽  
Camila Olivo de Carvalho ◽  
Márcia Cristina de Sena Oliveira ◽  
Rodney Alexandre Rodrigues ◽  
...  

The activity of plant extracts on parasites may indicate groups of substances that are potentially useful for controlling Rhipicephalus (Boophilus) microplus. The aim of the present study was to investigate the in vitro action of Artemisia annua extracts on this tick. The concentrations of the sesquiterpene lactones artemisinin and deoxyartemisinin present in plant extracts were quantified via high-performance liquid chromatography. Four extracts produced from the concentrated crude extract (CCE) were evaluated on larvae using the impregnated paper method, with readings after 24 hours of incubation. The engorged females were immersed in the CCE and in its four derived extracts for five minutes, with incubation for subsequent analysis of biological parameters. The extracts were not effective on the larvae at the concentrations tested (3.1 to 50 mg.mL-1). The CCE showed greater efficacy on engorged females (EC50 of 130.6 mg.mL-1 and EC90 of 302.9 mg.mL-1) than did the derived extracts. These results tend to confirm that the action of artemisinin on engorged females of R.(B.) microplus is conditional to their blood intake. In this case, in vitro methods would be inadequate for effective evaluation of the action of A. annua on R. (B.) microplus.


2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1278-1285
Author(s):  
Mohamed Yafout ◽  
Amine Ousaid ◽  
Ibrahim Sbai El Otmani ◽  
Youssef Khayati ◽  
Amal Ait Haj Said

The new SARS-CoV-2 belonging to the coronaviruses family has caused a pandemic affecting millions of people around the world. This pandemic has been declared by the World Health Organization as an international public health emergency. Although several clinical trials involving a large number of drugs are currently underway, no treatment protocol for COVID-19 has been officially approved so far. Here we demonstrate through a search in the scientific literature that the traditional Moroccan pharmacopoeia, which includes more than 500 medicinal plants, is a fascinating and promising source for the research of natural molecules active against SARS-CoV-2. Multiple in-silico and in-vitro studies showed that some of the medicinal plants used by Moroccans for centuries possess inhibitory activity against SARS-CoV or SARS-CoV-2. These inhibitory activities are achieved through the different molecular mechanisms of virus penetration and replication, or indirectly through stimulation of immunity. Thus, the potential of plants, plant extracts and molecules derived from plants that are traditionally used in Morocco and have activity against SARS-CoV-2, could be explored in the search for a preventive or curative treatment against COVID-19. Furthermore, safe plants or plant extracts that are proven to stimulate immunity could be officially recommended by governments as nutritional supplements.


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