Neuroprotective Role of Neurokinin B (NKB) on β-amyloid (25–35) Induced Toxicity in Aging Rat Brain Synaptosomes: Involvement in Oxidative Stress and Excitotoxicity

2006 ◽  
Vol 7 (1) ◽  
pp. 1-17 ◽  
Author(s):  
Anil K. Mantha ◽  
K. Moorthy ◽  
Sudha M. Cowsik ◽  
Najma Z. Baquer
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Neurokinin B ◽  
Rat Brain Synaptosomes ◽  
Aging Rat ◽  
Brain Synaptosomes ◽  
Β Amyloid

P3-324: Beta-amyloid neurotoxicity and neuroprotective role of 17β estradiol in aging rat brain synaptosomes

2012 ◽  
Vol 8 (4S_Part_15) ◽  
pp. P572-P572
Author(s):  
Pardeep Kumar ◽  
R.K. Kale ◽  
S.M. Cowsik ◽  
Najma Baquer
Keyword(s):  
Rat Brain ◽  
Beta Amyloid ◽  
Rat Brain Synaptosomes ◽  
Aging Rat ◽  
Brain Synaptosomes ◽  
17Β Estradiol

Membrane Associated Functions of Neurokinin B (NKB) on Aβ (25–35) Induced Toxicity in Aging Rat Brain Synaptosomes

2006 ◽  
Vol 7 (1) ◽  
pp. 19-33 ◽  
Author(s):  
Anil K. Mantha ◽  
K. Moorthy ◽  
Sudha M. Cowsik ◽  
Najma Z. Baquer
Keyword(s):  
Rat Brain ◽  
Neurokinin B ◽  
Rat Brain Synaptosomes ◽  
Aging Rat ◽  
Brain Synaptosomes ◽  
Associated Functions

scholarly journals Role of iron, zinc and reduced glutathione in oxidative stress induction by low pH in rat brain synaptosomes

SpringerPlus ◽  
2014 ◽  
Vol 3 (1) ◽  
pp. 560 ◽  
Author(s):  
Tatyana G Pekun ◽  
Sviatlana V Hrynevich ◽  
Tatyana V Waseem ◽  
Sergei V Fedorovich
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Reduced Glutathione ◽  
Low Ph ◽  
Stress Induction ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes

Quinolinic acid induces oxidative stress in rat brain synaptosomes

Neuroreport ◽  
2001 ◽  
Vol 12 (4) ◽  
pp. 871-874 ◽  
Author(s):  
Abel Santamaría ◽  
Sonia Galván-Arzate ◽  
Václav Lisý ◽  
Syed F. Ali ◽  
Helen M. Duhart ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Quinolinic Acid ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes

scholarly journals Uptake of Agmatine into Rat Brain Synaptosomes: Possible Role of Cation Channels

2002 ◽  
Vol 69 (6) ◽  
pp. 2421-2426 ◽  
Author(s):  
Magdalena Sastre ◽  
Soundararajan Regunathan ◽  
Donald J. Reis
Keyword(s):  
Rat Brain ◽  
Cation Channels ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes

Parathyroid hormone mediates changes in calcium transport in uremic rat brain synaptosomes

1988 ◽  
Vol 254 (6) ◽  
pp. F837-F844 ◽  
Author(s):  
C. L. Fraser ◽  
P. Sarnacki
Keyword(s):  
Parathyroid Hormone ◽  
Rat Brain ◽  
Calcium Transport ◽  
Base Line ◽  
Transport Mechanisms ◽  
Rat Brain Synaptosomes ◽  
Transport Studies ◽  
Brain Synaptosomes ◽  
Uptake Studies

In previous studies, we showed that Ca2+ transport by both Na+ gradient-stimulated Ca2+ uptake and ATP-stimulated Ca2+ uptake was increased in synaptosomes from uremic rat brain. The possible role of parathyroid hormone (PTH) in this observation was investigated by performing Ca2+ transport studies in synaptosomes by these two mechanisms. Studies were performed in vesicles from rats that were either normal, uremic, uremic parathyroidectomized (PTX-U), or uremic parathyroidectomized but treated with PTH. In uremic rats, transport by both Na+ gradient-stimulated Ca2+ uptake and ATP-stimulated Ca2+ uptake was increased by 30 and 47%, respectively, whereas uptake was returned to base line in synaptosomes from PTX-U rats. Additionally, the administration of PTH to PTX-U rats resulted in a significant increase (P less than 0.001) of 36 and 41%, respectively, above the values observed in PTX-U rats. To determine whether the increased accumulation of Ca2+ in synaptosomes in uremia was a result of PTH alone and/or to the uremic environment, we next performed uptake studies in synaptosomes that were isolated from nonuremic rats that were either normal, parathyroidectomized (PTX) or PTX but treated with 2.8–100 micrograms PTH. By both transport mechanisms, uptake was significantly (P less than 0.01) decreased from normal by 27% in the PTX group, and either 2.8 or 110 micrograms PTH resulted in a significant increase in transport to base line by Na+-gradient stimulated Ca2+ uptake. However, Ca2+ accumulation by ATP-stimulated Ca2+ uptake was significantly increased to base line only with 100 micrograms PTH.(ABSTRACT TRUNCATED AT 250 WORDS)

Role of Ca 2+ in Metabolic Inhibition–Induced Norepinephrine Release in Rat Brain Synaptosomes

1997 ◽  
Vol 80 (2) ◽  
pp. 179-188 ◽  
Author(s):  
Xiao-Jun Du ◽  
Alex Bobik ◽  
Peter J. Little ◽  
Murray D. Esler ◽  
Anthony M. Dart
Keyword(s):  
Rat Brain ◽  
Metabolic Inhibition ◽  
Norepinephrine Release ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes

scholarly journals Neuroprotective and antioxidant activities of saponins’ mixture from Astragalus glycyphylloides in a model of 6-hydroxydopamine-induced oxidative stress on isolated rat brain synaptosomes

Pharmacia ◽  
2019 ◽  
Vol 66 (4) ◽  
pp. 233-236
Author(s):  
Magdalena Kondeva-Burdina ◽  
Ilina Krasteva ◽  
Georgi Popov ◽  
Vasil Manov
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Antioxidant Activities ◽  
Toxic Metabolite ◽  
Neuroprotective Effects ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes ◽  
6 Hydroxydopamine ◽  
Isolated Rat ◽  
Significant Concentration

The aim of the study was to investigate the possible neuroprotective and antioxidant activity of purified saponins’mixture (PSM), isolated from Astragalus glycyphylloides (Fabaceae), in a model of 6-hydroxydipamine (6-OHDA)-induced oxidative stress on isolated rat brain synaptosomes. Synaptosomes were incubated with 3 different concentrations of PSM: 60 µg/mL; 6 µg/mL; 0.6 µg/mL. The effects of PSM were compared to those of silymarin (S), at the same concentrations. The main parameters, characterized functional and metabolic status of synaptosomes, were investigated: viability (MTT-test) and level of reduced glutathione (GSH). At isolated rat brain synaptosomes, in conditions of 6-OHDA-induced oxidative stress (150 μМ), PSM revealed statistically significant, concentration-dependent, neuroprotective and antioxidant effects, compared to those of silymarin. Effects were most prominent at concentration 60 µg/mL. These neuroprotective effects of PSM might be due to the possible activity as scavenger of reactive oxygen species (ROS), produced by p-quinone (toxic metabolite of 6-OHDA).

Experimental Evidence that 3-Methylglutaric Acid Disturbs Mitochondrial Function and Induced Oxidative Stress in Rat Brain Synaptosomes: New Converging Mechanisms

2016 ◽  
Vol 41 (10) ◽  
pp. 2619-2626 ◽  
Author(s):  
Ana Laura Colín-González ◽  
Ariana Lizbeth Paz-Loyola ◽  
María Eduarda de Lima ◽  
Sonia Galván-Arzate ◽  
Bianca Seminotti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Experimental Evidence ◽  
Rat Brain ◽  
Mitochondrial Function ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes
Sign in / Sign up

Export Citation Format

Share Document