In Vitro Effects of Ethanol With Aspirin on Rat Brain Synaptosomes: The Potential Protective Role of Betaine

2010 ◽  
Vol 120 (12) ◽  
pp. 774-783 ◽  
Author(s):  
Ibrahim Sogut ◽  
Gungor Kanbak
2003 ◽  
Vol 21 (2) ◽  
pp. 75-82 ◽  
Author(s):  
Daniela Balz ◽  
Angela Terezinha Souza Wyse ◽  
Vera Maria Morsch ◽  
Adriane Cismoski Silva ◽  
Vânia Lúcia Vieira ◽  
...  

2002 ◽  
Vol 69 (6) ◽  
pp. 2421-2426 ◽  
Author(s):  
Magdalena Sastre ◽  
Soundararajan Regunathan ◽  
Donald J. Reis

1987 ◽  
Vol 48 (4) ◽  
pp. 1278-1284 ◽  
Author(s):  
Jose Sanchez-Prieto ◽  
Stephen A. K. Harvey ◽  
John B. Clark

1980 ◽  
Vol 89 (2) ◽  
pp. 108-111
Author(s):  
V. I. Rodina ◽  
L. K. Salata ◽  
V. V. Rozhanets ◽  
O. M. Pozdnyakov ◽  
R. N. Glebov

1988 ◽  
Vol 254 (6) ◽  
pp. F837-F844 ◽  
Author(s):  
C. L. Fraser ◽  
P. Sarnacki

In previous studies, we showed that Ca2+ transport by both Na+ gradient-stimulated Ca2+ uptake and ATP-stimulated Ca2+ uptake was increased in synaptosomes from uremic rat brain. The possible role of parathyroid hormone (PTH) in this observation was investigated by performing Ca2+ transport studies in synaptosomes by these two mechanisms. Studies were performed in vesicles from rats that were either normal, uremic, uremic parathyroidectomized (PTX-U), or uremic parathyroidectomized but treated with PTH. In uremic rats, transport by both Na+ gradient-stimulated Ca2+ uptake and ATP-stimulated Ca2+ uptake was increased by 30 and 47%, respectively, whereas uptake was returned to base line in synaptosomes from PTX-U rats. Additionally, the administration of PTH to PTX-U rats resulted in a significant increase (P less than 0.001) of 36 and 41%, respectively, above the values observed in PTX-U rats. To determine whether the increased accumulation of Ca2+ in synaptosomes in uremia was a result of PTH alone and/or to the uremic environment, we next performed uptake studies in synaptosomes that were isolated from nonuremic rats that were either normal, parathyroidectomized (PTX) or PTX but treated with 2.8–100 micrograms PTH. By both transport mechanisms, uptake was significantly (P less than 0.01) decreased from normal by 27% in the PTX group, and either 2.8 or 110 micrograms PTH resulted in a significant increase in transport to base line by Na+-gradient stimulated Ca2+ uptake. However, Ca2+ accumulation by ATP-stimulated Ca2+ uptake was significantly increased to base line only with 100 micrograms PTH.(ABSTRACT TRUNCATED AT 250 WORDS)


1997 ◽  
Vol 80 (2) ◽  
pp. 179-188 ◽  
Author(s):  
Xiao-Jun Du ◽  
Alex Bobik ◽  
Peter J. Little ◽  
Murray D. Esler ◽  
Anthony M. Dart

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