Experimental Evidence that 3-Methylglutaric Acid Disturbs Mitochondrial Function and Induced Oxidative Stress in Rat Brain Synaptosomes: New Converging Mechanisms

2016 ◽  
Vol 41 (10) ◽  
pp. 2619-2626 ◽  
Author(s):  
Ana Laura Colín-González ◽  
Ariana Lizbeth Paz-Loyola ◽  
María Eduarda de Lima ◽  
Sonia Galván-Arzate ◽  
Bianca Seminotti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Experimental Evidence ◽  
Rat Brain ◽  
Mitochondrial Function ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes

Quinolinic acid induces oxidative stress in rat brain synaptosomes

Neuroreport ◽  
2001 ◽  
Vol 12 (4) ◽  
pp. 871-874 ◽  
Author(s):  
Abel Santamaría ◽  
Sonia Galván-Arzate ◽  
Václav Lisý ◽  
Syed F. Ali ◽  
Helen M. Duhart ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Quinolinic Acid ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes

scholarly journals Neuroprotective and antioxidant activities of saponins’ mixture from Astragalus glycyphylloides in a model of 6-hydroxydopamine-induced oxidative stress on isolated rat brain synaptosomes

Pharmacia ◽  
2019 ◽  
Vol 66 (4) ◽  
pp. 233-236
Author(s):  
Magdalena Kondeva-Burdina ◽  
Ilina Krasteva ◽  
Georgi Popov ◽  
Vasil Manov
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Antioxidant Activities ◽  
Toxic Metabolite ◽  
Neuroprotective Effects ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes ◽  
6 Hydroxydopamine ◽  
Isolated Rat ◽  
Significant Concentration

The aim of the study was to investigate the possible neuroprotective and antioxidant activity of purified saponins’mixture (PSM), isolated from Astragalus glycyphylloides (Fabaceae), in a model of 6-hydroxydipamine (6-OHDA)-induced oxidative stress on isolated rat brain synaptosomes. Synaptosomes were incubated with 3 different concentrations of PSM: 60 µg/mL; 6 µg/mL; 0.6 µg/mL. The effects of PSM were compared to those of silymarin (S), at the same concentrations. The main parameters, characterized functional and metabolic status of synaptosomes, were investigated: viability (MTT-test) and level of reduced glutathione (GSH). At isolated rat brain synaptosomes, in conditions of 6-OHDA-induced oxidative stress (150 μМ), PSM revealed statistically significant, concentration-dependent, neuroprotective and antioxidant effects, compared to those of silymarin. Effects were most prominent at concentration 60 µg/mL. These neuroprotective effects of PSM might be due to the possible activity as scavenger of reactive oxygen species (ROS), produced by p-quinone (toxic metabolite of 6-OHDA).

In vitro evaluation of neurotoxicity potential and oxidative stress responses of diazinon and its degradation products in rat brain synaptosomes

2015 ◽  
Vol 233 (1) ◽  
pp. 29-37 ◽  
Author(s):  
Mirjana B. Čolović ◽  
Vesna M. Vasić ◽  
Nataša S. Avramović ◽  
Milan M. Gajić ◽  
Dragan M. Djurić ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Stress Responses ◽  
Degradation Products ◽  
In Vitro Evaluation ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes ◽  
Oxidative Stress Responses ◽  
And Oxidative Stress

scholarly journals Role of iron, zinc and reduced glutathione in oxidative stress induction by low pH in rat brain synaptosomes

SpringerPlus ◽  
2014 ◽  
Vol 3 (1) ◽  
pp. 560 ◽  
Author(s):  
Tatyana G Pekun ◽  
Sviatlana V Hrynevich ◽  
Tatyana V Waseem ◽  
Sergei V Fedorovich
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Reduced Glutathione ◽  
Low Ph ◽  
Stress Induction ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes

scholarly journals Identification of protein receptor for Clostridium botulinum type B neurotoxin in rat brain synaptosomes.

1994 ◽  
Vol 269 (14) ◽  
pp. 10498-10503 ◽  
Author(s):  
T. Nishiki ◽  
Y. Kamata ◽  
Y. Nemoto ◽  
A. Omori ◽  
T. Ito ◽  
...  
Keyword(s):  
Rat Brain ◽  
Clostridium Botulinum ◽  
Type B ◽  
Rat Brain Synaptosomes ◽  
Protein Receptor ◽  
Botulinum Type ◽  
Brain Synaptosomes

Is the Augmentation of K+-Evoked Intrasynaptosomal Ca2+Concentration Due to the Influx of Ca2+in Rat Brain Synaptosomes?

1989 ◽  
Vol 52 (6) ◽  
pp. 1837-1842 ◽  
Author(s):  
Mitsuko Okada ◽  
Kazunori Mine ◽  
Katsunori Iwasaki ◽  
Michihiro Fujiwara
Keyword(s):  
Rat Brain ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes

Action of pyrethroids on K+-stimulated calcium uptake by, and [3H]nimodipine binding to, rat brain synaptosomes

1988 ◽  
Vol 32 (2) ◽  
pp. 114-122 ◽  
Author(s):  
Adel A. Ramadan ◽  
Nabila M. Bakry ◽  
Abdel-Salam M. Marei ◽  
Amira T. Eldefrawi ◽  
Mohyee E. Eldefrawi
Keyword(s):  
Rat Brain ◽  
Calcium Uptake ◽  
Rat Brain Synaptosomes ◽  
Brain Synaptosomes
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