The effects of lanthanum chloride on proliferation and apoptosis of cervical cancer cells: involvement of let-7a and miR-34a microRNAs

BioMetals ◽  
2015 ◽  
Vol 28 (5) ◽  
pp. 879-890 ◽  
Author(s):  
Lingfang Yu ◽  
Jieqi Xiong ◽  
Ling Guo ◽  
Lifang Miao ◽  
Sisun Liu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Lanthanum Chloride ◽  
Proliferation And Apoptosis ◽  
Cervical Cancer Cells

scholarly journals Cytotoxic Effects of Native and Recombinant Frutalin, a Plant Galactose-Binding Lectin, on HeLa Cervical Cancer Cells

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Carla Oliveira ◽  
Ana Nicolau ◽  
José A. Teixeira ◽  
Lucília Domingues
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Hela Cells ◽  
Carbohydrate Binding ◽  
Binding Affinities ◽  
Proliferation And Apoptosis ◽  
Cervical Cancer Cells ◽  
Different Sources ◽  
Binding Lectin ◽  
Galactose Binding Lectin

Frutalin is theα-D-galactose-binding lectin isolated from breadfruit seeds. Frutalin was obtained from two different sources: native frutalin was purified from its natural origin, and recombinant frutalin was produced and purified fromPichia pastoris. This work aimed to study and compare the effect of native and recombinant frutalin on HeLa cervical cancer cells proliferation and apoptosis. Furthermore, the interaction between frutalin and the HeLa cells was investigated by confocal microscopy. Despite having different carbohydrate-binding affinities, native and recombinant frutalin showed an identical magnitude of cytotoxicity on HeLa cells growth (IC50~100 μg/mL) and equally induced cell apoptosis. The interaction studies showed that both lectins were rapidly internalised and targeted to HeLa cell's nucleus. Altogether, these results indicate that frutalin action is not dependent on its sugar-binding properties. This study provides important information about the bioactivity of frutalin and contributes to the understanding of the plant lectins cytotoxic activity.

scholarly journals Inhibition of protease-activated receptor-2 induces apoptosis in cervical cancer by inhibiting signal transducer and activator of transcription-3 signaling

2019 ◽  
Vol 47 (3) ◽  
pp. 1330-1338 ◽  
Author(s):  
Hu Shanshan ◽  
Xiao Lan ◽  
Li Xia ◽  
Wang Huang ◽  
Zuo Meifang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Western Blotting ◽  
Cell Counting ◽  
Signal Transducer ◽  
Proliferation And Apoptosis ◽  
Cervical Cancer Cells ◽  
Protease Activated Receptor 2 ◽  
Transcription 3

Objective The present study explored how the inhibition of protease-activated receptor-2 (PAR-2) induced proliferation and apoptosis in cervical cancer in vitro and in vivo. Methods mRNA and protein expression of PAR2 and signal transducer and activator of transcription-3 (STAT-3) was determined by quantitative real-time PCR and western blotting. The proliferation and apoptosis of cervical cancer cells were assayed by the cell counting kit-8 kit, flow cytometry, and western blotting. The effects of PAR2 inhibition on cervical cancer were also examined in BALB/c nude mice in vivo. Results SLIGRL-NH2 (SL), a selective PAR-2 agonist, promoted proliferation and inhibited apoptosis of healthy cervical cancer cells and HeLa cells, while the PAR-2 antagonist FSLLRY-NH2 (FS) inhibited proliferation and led to apoptosis. SL also promoted the activation of STAT-3, while FS inhibited it and inhibited cancer growth in vivo. Conclusion FS inhibited cervical cancer by reducing proliferation and inducing apoptosis by interfering with STAT-3 signaling.

RETRACTED: miR-149 regulates the proliferation and apoptosis of cervical cancer cells by targeting GIT1

2018 ◽  
Vol 105 ◽  
pp. 1106-1116 ◽  
Author(s):  
Bing Qian ◽  
LiJun Zhao ◽  
XiaoFang Wang ◽  
Juan Xu ◽  
Fang Teng ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Proliferation And Apoptosis ◽  
Cervical Cancer Cells
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