Immunoliposome encapsulation increases cytotoxic activity and selectivity of curcumin and resveratrol against HER2 overexpressing human breast cancer cells

2013 ◽  
Vol 141 (1) ◽  
pp. 55-65 ◽  
Author(s):  
Angela Catania ◽  
Enrique Barrajón-Catalán ◽  
Silvia Nicolosi ◽  
Federico Cicirata ◽  
Vicente Micol
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast

Cytotoxic activity of G3 PAMAM-NH2 dendrimer-chlorambucil conjugate in human breast cancer cells

2011 ◽  
Vol 32 (3) ◽  
pp. 364-372 ◽  
Author(s):  
Krzysztof Bielawski ◽  
Anna Bielawska ◽  
Anna Muszyńska ◽  
Bożena Popławska ◽  
Robert Czarnomysy
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast

Cytotoxic activity of octahydropyrazin[2,1-a:5,4-a′]diisoquinoline derivatives in human breast cancer cells

2014 ◽  
Vol 38 (5) ◽  
pp. 628-641 ◽  
Author(s):  
Monika Lepiarczyk ◽  
Zbigniew Kałuża ◽  
Anna Bielawska ◽  
Robert Czarnomysy ◽  
Agnieszka Gornowicz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast

Prediction of Extra Virgin Olive Oil Varieties through Their Phenolic Profile. Potential Cytotoxic Activity against Human Breast Cancer Cells

2010 ◽  
Vol 58 (18) ◽  
pp. 9942-9955 ◽  
Author(s):  
Jesús Lozano-Sánchez ◽  
Antonio Segura-Carretero ◽  
Javier A. Menendez ◽  
Cristina Oliveras-Ferraros ◽  
Lorenzo Cerretani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Phenolic Profile

Bacopasaponins with cytotoxic activity against human breast cancer cells in vitro

2021 ◽  
Author(s):  
Arindam Bandyopadhyay ◽  
Saraswati Garai ◽  
Prajna Paramita Banerjee ◽  
Shelley Bhattacharya ◽  
Ansuman Chattopadhyay
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals Cytotoxic Activity of Isoniazid Derivative in Human Breast Cancer Cells

In Vivo ◽  
2021 ◽  
Vol 35 (5) ◽  
pp. 2675-2685
Author(s):  
MUTTIAH BARATHAN ◽  
AHMAD KHUSAIRY ZULPA ◽  
KUMUTHA MALAR VELLASAMY ◽  
VANITHA MARIAPPAN ◽  
NAVEEN KUMAR HAWALA SHIVASHEKAREGOWDA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals Cytotoxic Activity of Fatty Acids From Antarctic Macroalgae on the Growth of Human Breast Cancer Cells

2018 ◽  
Vol 6 ◽  
Author(s):  
Bruna Silveira Pacheco ◽  
Marco Aurélio Ziemann dos Santos ◽  
Eduarda Schultze ◽  
Rosiane Mastelari Martins ◽  
Rafael Guerra Lund ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Antarctic Macroalgae

scholarly journals Enhancement of Doxorubicin Cytotoxicity by Verapamil in Human Breast Cancer Cells

2019 ◽  
pp. 1-10
Author(s):  
Sameer E. Al-harthy ◽  
Mashael S. Al-Motairi ◽  
Huda M. Al-Kreathy ◽  
Fatemah O. Kamel ◽  
Mohamed M. Sayed-Ahmed ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Multidrug Resistant ◽  
Cycle Phase ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

Background: Worldwide, breast cancer is a main cause of morbidity and mortality in females. Doxorubicin (DOX) is an anthracycline anticancer drug and most commonly employed in polychemotherapy protocols in the treatment of solid and hematological tumors. Unfortunately, its optimal clinical benefit is limited secondary to the rapid development of DOX resistance and therapeutic failure. Aim: Therefore, the current study has been initiated to investigate the possible mechanisms whereby the calcium channel blocker Verapamil (VER) could decrease DOX resistance and enhance the cytotoxic activity of DOX against the growth of human breast cancer cells. Methodology: To achieve the ultimate goal of this study, we have examined DOX-induced cytotoxicity, apoptosis, alteration in the function of multidrug resistance proteins and cell cycle phase distribution against MCF-7 cell line in presence and absence of Verapamil.  Results: Addition of VER enhanced the cytotoxic effect of DOX against the growth of MCF-7 cells which manifested as a significant decrease in the IC50 from 36 µg/ml for DOX alone to 13 µg/ml for DOX plus VER.  Moreover, combined treatment with VER and DOX significantly increased percentage of early apoptosis and cells arrested in G0/G1 phase when compared to DOX alone. In addition, VER significantly increased DOX cellular uptake through inhibition of the function of multidrug resistant proteins.   Conclusion: VER treatment enhanced the cytotoxic activity of DOX against the growth of MCF-7 cells secondary to increase its cellular accumulation.  The observed increase in DOX uptake by VER was parallel to increased accumulation of Rho-123 dye which my point to the contribution of inhibition of multidrug resistant proteins by VER in the enhancement of DOX cytotoxicity.

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