scholarly journals Detection of breast cancer stem cell gene mutations in circulating free DNA during the evolution of metastases

2019 ◽  
Vol 178 (2) ◽  
pp. 251-261
Author(s):  
Zhe-Bin Liu ◽  
Nader E. Ezzedine ◽  
Agda K. Eterovic ◽  
Joe E. Ensor ◽  
Helen J. Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Gene Mutations ◽  
Breast Cancer Stem Cell ◽  
Circulating Free Dna ◽  
Free Dna ◽  
Cell Gene ◽  
Stem Cell Gene

Abstract S4-03: Identification of a notch-driven breast cancer stem cell gene signature for anti-notch therapy in an ER+ presurgical window model

2015 ◽  
Author(s):  
Kathy S Albain ◽  
Andrei Y Zlobin ◽  
Kyle R Covington ◽  
Brian T Gallahger ◽  
Susan G Hilsenbeck ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Gene Signature ◽  
Breast Cancer Stem Cell ◽  
Cell Gene ◽  
Stem Cell Gene

scholarly journals Enrichment of CD44 in basal-type breast cancer correlates with EMT, cancer stem cell gene profile, and prognosis

2016 ◽  
pp. 431 ◽  
Author(s):  
Kongming Wu ◽  
Hanxiao Xu ◽  
Xun Yuan ◽  
Yijun Tian ◽  
Yu Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Gene Profile ◽  
Cell Gene ◽  
Stem Cell Gene ◽  
Basal Type

Regulation of Breast Cancer Stem Cell by Tissue Rigidity

2015 ◽  
Author(s):  
Jing Yang ◽  
Adam Engler ◽  
Laurent Fattet ◽  
Matthew Ondeck
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Breast Cancer Stem Cell

scholarly journals Breast Cancer Stem Cell Potency of Nickel(II)‐Polypyridyl Complexes Containing Non‐steroidal Anti‐inflammatory Drugs

2020 ◽  
Vol 26 (61) ◽  
pp. 14011-14017
Author(s):  
Catherine J. Feld ◽  
Alice Johnson ◽  
Zhiyin Xiao ◽  
Kogularamanan Suntharalingam
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Breast Cancer Stem Cell ◽  
Polypyridyl Complexes ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Nanosized Drug Delivery Systems for Breast Cancer Stem Cell Targeting

2021 ◽  
Vol Volume 16 ◽  
pp. 1487-1508
Author(s):  
Li Lv ◽  
Yonghui Shi ◽  
Junyan Wu ◽  
Guocheng Li
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Breast Cancer Stem Cell ◽  
Cell Targeting

scholarly journals Identification of a Novel Stem Cell Subtype for Clear Cell Renal Cell Carcinoma Based on Stem Cell Gene Profiling

2021 ◽  
Vol 11 ◽  
Author(s):  
Hongzhi Wang ◽  
Hanjiang Xu ◽  
Quan Cheng ◽  
Chaozhao Liang
Keyword(s):  
Renal Cell Carcinoma ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Renal Cancer ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Gene Sets ◽  
Cell Gene ◽  
Stem Cell Gene

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer and is characterized by high rates of metastasis. Cancer stem cell is a vital cause of renal cancer metastasis and recurrence. However, little is known regarding the change and the roles of stem cells during the development of renal cancer. To clarify this problem, we developed a novel stem cell clustering strategy. Based on The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) genomic datasets, we used 19 stem cell gene sets to classify each dataset. A machine learning method was used to perform the classification. We classified ccRCC into three subtypes—stem cell activated (SC-A), stem cell dormant (SC-D), and stem cell excluded (SC-E)—based on the expressions of stem cell-related genes. Compared with the other subtypes, C2(SC-A) had the highest degree of cancer stem cell concentration, the highest level of immune cell infiltration, a distinct mutation landscape, and the worst prognosis. Moreover, drug sensitivity analysis revealed that subgroup C2(SC-A) had the highest sensitivity to immunotherapy CTLA-4 blockade and the vascular endothelial growth factor receptor (VEGFR) inhibitor sunitinib. The identification of ccRCC subtypes based on cancer stem cell gene sets demonstrated the heterogeneity of ccRCC and provided a new strategy for its treatment.

Breast Cancer Stem Cell: Translating to the Clinic

2011 ◽  
pp. 249-257 ◽  
Author(s):  
Makiko Ono ◽  
Yasuhiro Fujiwara ◽  
Takahiro Ochiya
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Breast Cancer Stem Cell
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