Assessment of microembolization associated with revascularization in acute myocardial infarction: MDCT cardiac perfusion and function study

2013 ◽  
Vol 29 (8) ◽  
pp. 1861-1869 ◽  
Author(s):  
Maythem Saeed ◽  
Steven W. Hetts ◽  
Loi Do ◽  
Mark W. Wilson
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cardiac Perfusion ◽  
Function Study ◽  
And Function

STRUCTURALAND FUNCTIONAL CHANGES OF HEART IN DEPENDENCE OF GALLBLADDER CONDITION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

2020 ◽  
Vol 86 (1) ◽  
pp. 16-20
Author(s):  
L. M. Strilchuk
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Systolic Function ◽  
Systolic Dysfunction ◽  
Functional Changes ◽  
Pathological Conditions ◽  
Optimal Values ◽  
And Function

According to the literature data, gallbladder (GB) condition influences the course of coronary heart disease (CHD) and parameters of heart structure and function. The aim of this work was to estimate the peculiarities of heart condition in patients with CHD (acute myocardial infarction) in dependence of GB condition. We held a retrospective analysis of data of 142 patients. Results. It was revealed that in 83.7 % patients GB was changed: cholelithiasis (34.5 %), past cholecystectomy due to cholelithiasis (7.0 %), sludge and poliposis (17.6 %), bent GB body (13.4 %), neck deformations and signs of past cholecystitis (14.8 %). GB changes were accompanied by significant increase of heart rate, which was the most prominent in case of cholelithiasis, neck deformations and past cholecystitis signs. Conclusions. Pathological conditions of GB were accompanied by left ventricle dilatation, aortic distension, significant decrease of ejection fraction and systolic dysfunction, whereas after GB removal sizes of heart chambers were close to optimal values, although the systolic function did not normalize. Keywords: gallbladder, coronary heart disease, sludge, cholecystitis, heart structure.

scholarly journals Integration of “omics” techniques: Dronedarone affects cardiac remodeling in the infarction border zone

2018 ◽  
Vol 243 (11) ◽  
pp. 895-910 ◽  
Author(s):  
Ravi K Chilukoti ◽  
Josefine Lendeckel ◽  
Katrin Darm ◽  
Alicja Bukowska ◽  
Andreas Goette ◽  
...  
Keyword(s):  
Gene Expression ◽  
Myocardial Infarction ◽  
Atrial Fibrillation ◽  
Acute Myocardial Infarction ◽  
Infarct Size ◽  
Ischemia Reperfusion ◽  
Border Zone ◽  
Matricellular Proteins ◽  
Integrated Network ◽  
And Function

Dronedarone improves microvascular flow during atrial fibrillation and reduces the infarct size in acute models of myocardial infarction. However, dronedarone might be harmful in patients with recent decompensated heart failure and increases mortality in patients with permanent atrial fibrillation. A pathophysiological explanation for these discrepant data is lacking. This study investigated the effects of dronedarone on gene and protein expression in the infarcted area and border zone in pigs subjected to anterior ischemia/reperfusion myocardial infarction. The ischemia/reperfusion myocardial infarction was induced in 16 pigs. Eight pigs were treated with dronedarone for 28 days after myocardial infarction, the remaining pigs served as control. Microarray-based transcriptome profiling and 2D-DIGE-based proteome analysis were used to assess the effects of dronedarone on left ventricular gene expression in healthy (LV), infarcted (MI), and border zone tissue. Selected targets were validated by RT-qPCR or immunoblot analyses, with special emphasize given to the transcriptome/proteome overlap. Combined “omics” analysis was performed to identify most significant disease and function charts affected by dronedarone and to establish an integrated network. The levels of 879 (BZ) or 7 (MI) transcripts and 51 (LV) or 15 (BZ) proteins were significantly altered by dronedarone, pointing to a substantial efficacy of dronedarone in the border zone. Transcriptome and proteome data indicate that dronedarone influences post-infarction remodeling processes and identify matricellular proteins as major targets of dronedarone in this setting. This finding is fully supported by the disease and function charts as well as by the integrated network established by combined “omics”. Dronedarone therapy alters myocardial gene expression after acute myocardial infarction with pronounced effects in the border zone. Dronedarone promotes infarct healing via regulation of periostin and might contribute to the limitation of its expansion as well as cardiac rupture. Thus, there are no experimental hints that dronedarone per se has direct harmful effects after MI in ventricular tissue. Impact statement Dronedarone reduced the infarct size in models of acute myocardial infarction (MI). Here, we show that dronedarone attenuates many of the substantial changes in gene expression that are provoked by acute myocardial infarction (AMI) in pigs. Dronedarone modifies the expression of gene panels related to post-infarction cardiac healing and remodeling processes and, most remarkably, this occurs predominantly in the infarction border-zone and much less so in the vital or infarcted myocardium. Combined “omics” identified matricellular proteins and ECM as major dronedarone-regulated targets and emphasizes their relevance for Disease Charts and Tox Function Charts associated with tissue remodeling and cellular movement. The results demonstrate dronedarone’s capability of regulating cardiac repair and remodeling processes specifically in the infarction border zone and identify underlying mechanisms and pathways that might be employed in future therapeutic strategies to improve long-term cardiac tissue function and stability.

Cardiac FGF23: new insights into the role and function of FGF23 after acute myocardial infarction

2019 ◽  
Vol 40 ◽  
pp. 47-54 ◽  
Author(s):  
David Schumacher ◽  
Setareh Alampour-Rajabi ◽  
Victor Ponomariov ◽  
Adelina Curaj ◽  
Zhuojun Wu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
And Function ◽  
Role And Function
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