Sex-Related Differences in Clinical Symptoms, Quality of Life, and Biochemical Factors in Irritable Bowel Syndrome

2017 ◽  
Vol 62 (6) ◽  
pp. 1550-1560 ◽  
Author(s):  
Razieh Choghakhori ◽  
Amir Abbasnezhad ◽  
Reza Amani ◽  
Meysam Alipour
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Clinical Symptoms ◽  
Irritable Bowel

Association of Serum Vitamin D Concentration With Clinical Symptoms and Quality of Life in Patients With Irritable Bowel Syndrome

2018 ◽  
Vol 38 (4) ◽  
pp. 327-333 ◽  
Author(s):  
Amir Abbasnezhad ◽  
Reza Amani ◽  
Amin Hasanvand ◽  
Esmaeil Yousefi Rad ◽  
Meysam Alipour ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Vitamin D ◽  
Irritable Bowel Syndrome ◽  
Clinical Symptoms ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Irritable Bowel

Serum Levels of Chemerin, Apelin, and Adiponectin in Relation to Clinical Symptoms, Quality of Life, and Psychological Factors in Irritable Bowel Syndrome

2020 ◽  
Vol 54 (5) ◽  
pp. e40-e49
Author(s):  
Mohammad A. Baram ◽  
Amir Abbasnezhad ◽  
Koroush Ghanadi ◽  
Khatereh Anbari ◽  
Razieh Choghakhori ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Psychological Factors ◽  
Clinical Symptoms ◽  
Serum Levels ◽  
Irritable Bowel

Health releated quality of life in irritable bowel syndrome: A community based study+

2001 ◽  
Vol 120 (5) ◽  
pp. A634-A634 ◽  
Author(s):  
K OLDEN ◽  
W CHEY ◽  
J BOYLE ◽  
E CARTER ◽  
L CHANG
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Community Based ◽  
Irritable Bowel

P0075 THE IRRITABLE BOWEL SYNDROME AND ITS EFFECT ON THE QUALITY OF LIFE

2009 ◽  
Vol 20 ◽  
pp. S32
Author(s):  
Sevinç Kutlutürkan ◽  
Ülkü Görgülü ◽  
Hatice Fesci
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Irritable Bowel

scholarly journals Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review

2021 ◽  
Vol 14 ◽  
pp. 175628482199358
Author(s):  
Nikita Hanning ◽  
Adam L. Edwinson ◽  
Hannah Ceuleers ◽  
Stephanie A. Peters ◽  
Joris G. De Man ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Barrier Function ◽  
Significant Proportion ◽  
Healthy Controls ◽  
Barrier Dysfunction ◽  
Irritable Bowel

Background and Aim: Irritable bowel syndrome (IBS) is a complex and heterogeneous disorder. Sensory, motor and barrier dysfunctions are the key physiological endophenotypes of IBS. Our aim is to review studies evaluating barrier dysfunction in adults and children with IBS, as well as to link those changes with IBS symptomatology and quality of life. Methods: A comprehensive and systematic review of multiple databases was performed up to March 2020 to identify studies comparing intestinal permeability in IBS patients with healthy controls. Both in vivo and in vitro studies were considered. Results: We identified 66 studies, of which 27 used intestinal probes to quantify barrier function. The prevalence of barrier dysfunction differed between PI-IBS (17–50%), IBS-D (37–62%) and IBS-C (4–25%). At a group level, permeability was increased compared with healthy controls in IBS-D (9/13 studies) and PI-IBS (4/4 studies), but only a minority of IBS-C (2/7 studies) and not in the only IBS-M study. All four studies in children with IBS demonstrated loss of barrier function. A heterogeneous set of tight junction genes were found to be altered in small and large intestines of adults with IBS, but these have not been evaluated in children. Positive associations were identified between barrier dysfunction and bowel disturbances (6/9 studies), abdominal pain (9/13 studies), overall symptom severity (1/6 studies), depression and anxiety (1/1 study) and quality of life (1/4 studies). Fecal slurry or supernatants of IBS patients were found to induce barrier disruption in animal models (5/6 studies). Conclusions: Barrier dysfunction is present in a significant proportion of adult and all pediatric IBS studies, especially in the IBS-D and PI-IBS subtype. The majority of studies indicated a positive association between loss of barrier function and symptoms such as abdominal pain and changes in the bowel function.

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