Phase 1 study of 2 high dose intensity schedules of the pan-Notch inhibitor crenigacestat (LY3039478) in combination with prednisone in patients with advanced or metastatic cancer

2020 ◽  
Author(s):  
Analía Azaro ◽  
Capucine Baldini ◽  
Jordi Rodon ◽  
Jean-Charles Soria ◽  
Eunice Yuen ◽  
...  
Keyword(s):  
Metastatic Cancer ◽  
Phase 1 ◽  
Dose Intensity ◽  
High Dose ◽  
Phase 1 Study ◽  
High Dose Intensity

High-dose intensity systemic therapy of metastatic bladder cancer.

1987 ◽  
Vol 5 (3) ◽  
pp. 450-455 ◽  
Author(s):  
W J Hrushesky ◽  
R V Roemeling ◽  
P A Wood ◽  
T R Langevin ◽  
P Lange ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Combination Chemotherapy ◽  
Systemic Therapy ◽  
Metastatic Cancer ◽  
Transitional Cell ◽  
Dose Intensity ◽  
High Dose ◽  
Complete Disappearance ◽  
Carcinoma Of The Bladder ◽  
High Dose Intensity

Forty-three consecutively diagnosed patients with widely metastatic transitional cell carcinoma of the bladder (TCCB) were treated with a high-dose intensity, chronobiologically timed combination of doxorubicin and cisplatin, followed by Cytoxan (Mead Johnson Pharmaceuticals, Evansville, IN), 5-fluorouracil (5-FU), and cisplatin maintenance for up to 2 years. Fifty-seven percent of the 35 evaluable patients with widespread metastatic cancer responded objectively. Twenty-three percent had complete disappearance of all cancer. Median survival from first treatment for complete responders (CRs) was more than 2 years, and 1 year for partial responders (PRs). Three of the CRs were alive without evidence of cancer more than 2 years after stopping all therapy. High-dose intensity combination chemotherapy can induce durable CRs of widespread bladder cancer.

High-dose-intensity combination chemotherapy for advanced sarcomas: a pilot study

1998 ◽  
Vol 41 (6) ◽  
pp. 513-516
Author(s):  
Paolo Pronzato ◽  
Pierluigi Losardo ◽  
Floriana Pensa ◽  
Alessandra Tognoni
Keyword(s):  
Pilot Study ◽  
Combination Chemotherapy ◽  
Dose Intensity ◽  
High Dose ◽  
High Dose Intensity
Sign in / Sign up

Export Citation Format

Share Document