Background::
new and selective electrochemical sensor was developed for the determination
of levocetirizine dihydrochloride, which is an antihistaminic drug.
Method::
The investigation was performed by using cyclic, differential pulse and square wave voltammetric
methods on the β-cyclodextrin modified glassy carbon electrode. It is thereby planned to obtain
information about levocetirizine determination and its mechanism.
Result::
The efficiency of experimental parameters including pH, scan rate, and accumulation potential
and time on the anodic response of levocetirizine dihydrochloride was studied. By employing the developed
method and under optimized conditions, the current showed linear dependence with a concentration
in the range between 2 × 10-8 M and 6 × 10-6 M in pH 2.0 Britton Robinson (BR) buffer.
Conclusion::
The achieved limits of detection and quantification were found as 3.73 × 10-10 M and
1.24 × 10-9 M, respectively. In addition, the possibility of applying the developed sensor for real sample
analysis was investigated, so β-cyclodextrin modified glassy carbon electrode was used to determine
levocetirizine dihydrochloride in Xyzal® tablet dosage form. Finally, this sensor was successfully applied
to the real sample as a selective, simple, reproducible, repeatable electrochemical sensor.
