Why and how do researchers collaborate, share knowledge resources, data, and expertise? What kinds of infrastructures and services do they use, and what do they need for the future enhancement of collaborative research practices? The chapter focuses on existing and potential eResearch from a “user” perspective. Drawing on a study of ICT-enhanced research practices and needs conducted at seven Australian universities, it discusses how researchers engage with distributed research and use ICT for collaboration. Findings show significant current engagement of the majority of researchers in collaborative research, their acknowledgement of the potential of eResearch, and researchers’ general willingness to engage in collaborative eResearch. While there are some essential differences in the collaboration practices of research students and academics and between practices and challenges in different disciplinary domains, researchers who are more involved in collaborative research also adopt eResearch more extensively, more often use ICT-enhanced collaboration tools, share more of their data, and more often disseminate their findings via digital media.