Expression and prognostic role of SGTA in human breast carcinoma correlates with tumor cell proliferation

2014 ◽  
Vol 45 (6) ◽  
pp. 665-677 ◽  
Author(s):  
Ting Zhu ◽  
Zhengxiang Ji ◽  
Caixia Xu ◽  
Zhiyang Peng ◽  
Liang Gu ◽  
...  
2013 ◽  
Vol 45 (2) ◽  
pp. 169-180 ◽  
Author(s):  
Xiaobing Liu ◽  
Qichao Ni ◽  
Junfei Xu ◽  
Chenyi Sheng ◽  
Qingqing Wang ◽  
...  

2014 ◽  
Vol 97 (2) ◽  
pp. 191-201 ◽  
Author(s):  
Hua Wang ◽  
Xiao-Bing Liu ◽  
Jia-Hui Chen ◽  
Qing-Qing Wang ◽  
Jin-Peng Chen ◽  
...  

2015 ◽  
Vol 46 (2) ◽  
pp. 221-231 ◽  
Author(s):  
Yuhua Shi ◽  
Xiaobing Liu ◽  
Yongfang Sun ◽  
Dichen Wu ◽  
Aifeng Qiu ◽  
...  

1997 ◽  
Vol 3 (S2) ◽  
pp. 29-30
Author(s):  
J. Itoh ◽  
K. Yasumura ◽  
K. Ogawa ◽  
K. Kawai ◽  
A. Serizawa ◽  
...  

There have been considerable interests in the relationship between tumor cell proliferation and angiogenesis. In human breast carcinomas, it has been reported that angiogenesis is an independent prognostic factor and that proliferating factors are closely related with lymph node status. Therefore, the demonstration of proliferating and angiogenetic factors as well as the tumor blood vessels in human breast carcinoma simultaneously is important for clinical evaluation of breast cancer patients.CLSM has been an exciting new apparatus because of it's more powerful resolution than conventional light microscopy and the high-performance on 3D optical sectioning. Images taken with CLSM can be digitized and made variable for image analysis manipulation and computer-assisted 3D reconstructions.In the present study, we employed immunohistochemical comparative 3D visualization of proliferating and angiogenstic factors with microvessels in human breast carcinomas by CLSM.The tissues from the surgically resected breast carcinoma were fixed in cold 4 % paraformaldehyde(PFA) and routinely processed in paraffin wax.


2021 ◽  
Vol 50 (3) ◽  
pp. 28-30
Author(s):  
A. F. Urmancheeva ◽  
D. R. Zel'dovich ◽  
M. S. Shushania ◽  
A. V. Safronov

Peritoneal cytological investigation was carried out inpatients with endometrial cancer, who were subjected to hysteroscopy before the operation (37patients) or were operated on without hysteroscopy. Comparative analysis of the data didnt reveal the role of hysteroscopy in tumor cell dissemination.


2017 ◽  
Vol 1 (1) ◽  
pp. 1-13
Author(s):  
Michael J Gonzalez ◽  
Jorge Duconge

Diets high in unsaturated fatty acids, especially those containing high levels of linoleic acid, e.g., corn oil, enhance mammary gland tumorigenesis in experimental animals. In contrast, diets high in long-chain polyunsaturated fatty acids such as eicosapentaenoic (EPA) and docosahexaenoic (DHA), e.g. menhaden oil, appear to have a suppressive effect on this tumorigenic process. Many mechanisms have been proposed to explain the tumor inhibitory action exerted by menhaden oil and other fish oils, e.g., differences in prostaglandin metabolism, energy efficiency, alterations of the immune system, changes in lipid peroxidation, etc. Fundamental to a mechanistic understanding of this phenomenon, however, is an understanding as to whether or not the tumor inhibitory activities of dietary fish oil is mediated via an inhibition of tumor cell proliferation or mediated via an enhancement of tumor cell loss. Whether the amount of dietary fat or the type of fat effects mammary tumorigenic processes, via an effect on tumor cell proliferation or tumor cell loss, has not been clearly established. In the studies described in this communication, three methods were utilized to study tumor cell proliferation, i.e., H3-thymidine autoradiographic analysis, 5-bromo 2'-deoxyuridine (Brdu) flow cytometric analysis, and proliferative cell nuclear antigen (PCNA) flow cytometric analysis. Two methods were used to study tumor cell loss, i.e., a determination of the I125Urd tumor emission rate and a determination of a cell loss factor from the formulas of Steel and Begg. The tumor examined was the human breast carcinoma cell line MDA- MB231 maintained in athymic nude mouse. No significant difference in cell proliferation between carcinomas of mice fed a high corn oil diet (20% w/w) and a diet high in fish oil (19% menhaden oil, 1% corn oil). In contrast, a significant (p<0.05) increase in the rate of I125Urd emission rate and cell loss factor from the carcinomas in the fish oil fed mice compared to the corn oil fed mice was observed. In summary, the decreased tumor volume in the human breast carcinomas maintained in athymic nude mice fed a fish oil diet as compared to those fed a corn oil diet, appears to be due, at least in part, to an increased rate of carcinoma cell loss rather than a decreased rate of carcinoma cell proliferation.


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