A comparison of three different intravitreal treatment modalities of macular edema due to branch retinal vein occlusion

2017 ◽  
Vol 38 (4) ◽  
pp. 1549-1558 ◽  
Author(s):  
Havva Erdogan Kaldırım ◽  
Serpil Yazgan
2010 ◽  
Vol 35 (10) ◽  
pp. 925-929 ◽  
Author(s):  
Osman Çekiç ◽  
Mehmet Çakır ◽  
Ahmet Taylan Yazıcı ◽  
Neşe Alagöz ◽  
Ercüment Bozkurt ◽  
...  

Retinal vein occlusion is the second most common retinal vascular disorder after diabetic retinopathy and is considered to be an important cause of visual loss. There are several treatment modalities for branch retinal vein occlusion and specifically for its complications, such as macular edema, vitreous hemorrhage, retinal neovascularization, and retinal detachment. These treatment modalities are anti-aggregative therapy and fibrinolysis, isovolemic hemodilution, vitrectomy with or without sheathotomy, peripheral scatter and macular grid retinal laser therapy, non-steroid agents, intravitreal steroids ( triamcinolone, and dexamethasone implants), and intravitreal anti-vascular endothelial growth factors (anti-VEGFs) (bevacizumab, ranibizumab, aflibercept). In this review, the treatment modalities other than routinely performed anti-VEGF, steroid, and laser therapy in macular edema secondary to branch retinal vein occlusion and emerging therapies will be overviewed.


Macular edema is the most common cause of vision loss in branch retinal vein occlusion. Mechanism of macular edema in branch retinal vein occlusion is multifactorial and it has not yet been fully understood. With the new information obtained from the new studies, treatment modalities have been changed. Nowadays besides laser and intravitreal triamcinolone acetonide treatments, intravitreal antivascular endothelial growth factor and dexamethasone implant therapies are commonly used. In this review, we aimed to evaluate the intravitreal steroid treatment in branch retinal vein occlusion.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yoshimi Sugiura ◽  
Fumiki Okamoto ◽  
Tomoya Murakami ◽  
Shohei Morikawa ◽  
Takahiro Hiraoka ◽  
...  

AbstractTo evaluate the effects of intravitreal ranibizumab injection (IVR) on metamorphopsia in patients with branch retinal vein occlusion (BRVO), and to assess the relationship between metamorphopsia and inner retinal microstructure and other factors. Thirty-three treatment-naïve eyes of 33 patients with macular edema caused by BRVO with at least 12 months of follow-up were included. The degree of metamorphopsia was quantified using the M-CHARTS. Retinal microstructure was assessed with spectral-domain optical coherence tomography. Disorganization of the retinal inner layers (DRIL) at the first month after resolution of the macular edema (early DRIL) and at 12 months after treatment (after DRIL) was studied. Central retinal thickness (CRT), and status of the external limiting membrane as well as ellipsoid zone were also evaluated. IVR treatment significantly improved best-corrected visual acuity (BCVA) and CRT, but the mean metamorphopsia score did not improve even after 12 months. Post-treatment metamorphopsia scores showed a significant correlation with pre-treatment metamorphopsia scores (P < 0.005), the extent of early DRIL (P < 0.05) and after DRIL (P < 0.05), and the number of injections (P < 0.05). Multivariate analysis revealed that the post-treatment mean metamorphopsia score was significantly correlated with the pre-treatment mean metamorphopsia score (P < 0.05). IVR treatment significantly improved BCVA and CRT, but not metamorphopsia. Post-treatment metamorphopsia scores were significantly associated with pre-treatment metamorphopsia scores, the extent of DRIL, and the number of injections. Prognostic factor of metamorphopsia was the degree of pre-treatment metamorphopsia.


Retina ◽  
2017 ◽  
Vol 37 (4) ◽  
pp. 702-709 ◽  
Author(s):  
Yuko Miwa ◽  
Yuki Muraoka ◽  
Rie Osaka ◽  
Sotaro Ooto ◽  
Tomoaki Murakami ◽  
...  

2009 ◽  
Vol 44 (2) ◽  
pp. 154-159 ◽  
Author(s):  
Amir Ali Ahmadi ◽  
Jean Y. Chuo ◽  
Alexander Banashkevich ◽  
Patrick E. Ma ◽  
David A.L. Maberley

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