Validation of the Repetitive Behavior Scale-Revised in Spanish-Speakers Participants with Autism Spectrum Disorder

2017 ◽  
Vol 48 (1) ◽  
pp. 198-208 ◽  
Author(s):  
A. E. Martínez-González ◽  
J. A. Piqueras
Keyword(s):  
Autism Spectrum Disorder ◽  
Repetitive Behavior ◽  
Autism Spectrum ◽  
Spanish Speakers ◽  
Spectrum Disorder ◽  
Behavior Scale

Application of the Repetitive Behavior Scale-Revised – Italian version – in preschoolers with autism spectrum disorder

2016 ◽  
Vol 48 ◽  
pp. 43-52 ◽  
Author(s):  
Francesca Fulceri ◽  
Antonio Narzisi ◽  
Fabio Apicella ◽  
Giulia Balboni ◽  
Sara Baldini ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Repetitive Behavior ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Italian Version ◽  
Behavior Scale

Validating the Repetitive Behavior Scale-Revised in Young Children with Autism Spectrum Disorder

2010 ◽  
Vol 40 (12) ◽  
pp. 1521-1530 ◽  
Author(s):  
Pat Mirenda ◽  
◽  
Isabel M. Smith ◽  
Tracy Vaillancourt ◽  
Stelios Georgiades ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Young Children ◽  
Repetitive Behavior ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Young Children With Autism ◽  
Behavior Scale

Psychometric properties of the Repetitive Behavior Scale-Revised for individuals with autism spectrum disorder in Japan

2015 ◽  
Vol 15-16 ◽  
pp. 60-68 ◽  
Author(s):  
Naoko Inada ◽  
Hiroyuki Ito ◽  
Kazuhiro Yasunaga ◽  
Miho Kuroda ◽  
Ryoichiro Iwanaga ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Psychometric Properties ◽  
Repetitive Behavior ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Behavior Scale

scholarly journals The Gut-Brain Axis in Autism Spectrum Disorder: A Focus on the Metalloproteases ADAM10 and ADAM17

2020 ◽  
Vol 22 (1) ◽  
pp. 118
Author(s):  
Yuanpeng Zheng ◽  
Tessa A. Verhoeff ◽  
Paula Perez Pardo ◽  
Johan Garssen ◽  
Aletta D. Kraneveld
Keyword(s):  
Autism Spectrum Disorder ◽  
Intestinal Tract ◽  
Synapse Formation ◽  
Inflammatory Responses ◽  
Repetitive Behavior ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Protein Substrates ◽  
Specific Proteins ◽  
Membrane Bound

Autism Spectrum Disorder (ASD) is a spectrum of disorders that are characterized by problems in social interaction and repetitive behavior. The disease is thought to develop from changes in brain development at an early age, although the exact mechanisms are not known yet. In addition, a significant number of people with ASD develop problems in the intestinal tract. A Disintegrin And Metalloproteases (ADAMs) include a group of enzymes that are able to cleave membrane-bound proteins. ADAM10 and ADAM17 are two members of this family that are able to cleave protein substrates involved in ASD pathogenesis, such as specific proteins important for synapse formation, axon signaling and neuroinflammation. All these pathological mechanisms are involved in ASD. Besides the brain, ADAM10 and ADAM17 are also highly expressed in the intestines. ADAM10 and ADAM17 have implications in pathways that regulate gut permeability, homeostasis and inflammation. These metalloproteases might be involved in microbiota-gut–brain axis interactions in ASD through the regulation of immune and inflammatory responses in the intestinal tract. In this review, the potential roles of ADAM10 and ADAM17 in the pathology of ASD and as targets for new therapies will be discussed, with a focus on the gut–brain axis.

scholarly journals 2288 Neural correlates of face processing in autism spectrum disorder: A quantitative meta-analysis of current literature and future directions

2018 ◽  
Vol 2 (S1) ◽  
pp. 21-22
Author(s):  
Carla J. Ammons ◽  
Mary-Elizabeth Winslett ◽  
Rajesh K. Kana
Keyword(s):  
Autism Spectrum Disorder ◽  
Face Processing ◽  
Repetitive Behavior ◽  
Autism Spectrum ◽  
Small Sample ◽  
Spectrum Disorder ◽  
Future Research ◽  
Healthy Controls ◽  
Specific Level

OBJECTIVES/SPECIFIC AIMS: Autism spectrum disorder (ASD) affects 1 in 68 people and includes restricted, repetitive behavior, and social communication deficits. Aspects of face processing (i.e., identity, emotion perception) are impaired in some with ASD. Neuroimaging studies have shown aberrant patterns of brain activation and connectivity of face processing regions. However, small sample sizes and inconsistent results have hindered clinical utility of these findings. The study aims to establish consistent patterns of brain responses to faces in ASD and provide directions for future research. METHODS/STUDY POPULATION: Neuroimaging studies were identified through a multi-database search according to PRISMA guidelines. In total, 23 studies were retained for a sample size of 383 healthy controls and 345 ASD. Peak coordinates were extracted for activation likelihood estimation (ALE) in GingerALE v2.3.6. Follow-up ALE analyses investigated directed Versus undirected gaze, static Versus dynamic, emotional Versus neutral, and familiar Versus unfamiliar faces. RESULTS/ANTICIPATED RESULTS: Faces produced bilateral activation of the fusiform gyrus (FG) in healthy controls (−42 −52 −20; 22 −74 −12, p<0.05, FDR) and left FG activation in ASD (−42 −54 −16, p<0.05, FDR). Activation in both groups was lateral to the mid-fusiform sulcus. Follow-up results pending. DISCUSSION/SIGNIFICANCE OF IMPACT: Reduced right FG activation to faces may inform biomarker or response to intervention studies. Mid-fusiform sulcus proved a reliable predictor of functional divides should be investigated on a subject-specific level.

scholarly journals Periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder

2016 ◽  
Vol 10 ◽  
pp. 36-45 ◽  
Author(s):  
Karen Blackmon ◽  
Emma Ben-Avi ◽  
Xiuyuan Wang ◽  
Heath R. Pardoe ◽  
Adriana Di Martino ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
White Matter ◽  
Repetitive Behavior ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Periventricular White Matter ◽  
White Matter Abnormalities

scholarly journals SOME BIOCHEMICAL IMPLICATIONS IN AUTISM SPECTRUM DISORDER

2014 ◽  
Vol 2 (3) ◽  
Author(s):  
Cristiane Pinheiro Lázaro ◽  
Milena Pereira Pondé ◽  
Luiz Erlon A. Rodrigues
Keyword(s):  
Autism Spectrum Disorder ◽  
Repetitive Behavior ◽  
Clinical Manifestations ◽  
Laboratory Diagnosis ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Physiological Processes ◽  
Oppositional Defiant ◽  
Enzymatic Regulation ◽  
Nosological Entity

Autism spectrum disorder (ASD) affects 0.6 to 1% of the population worldwide. It is characterized by a deficit in communication and social interaction, and is associated with restricted and repetitive behavior patterns. Stereotypes include inflexible adhesion to specific non-functional routines and rituals and a persistent concern with parts of objects rather than the object as a whole. Up to the present time, there are no specific tests that permit a laboratory diagnosis of the disorder to be carried out, and the syndrome is confirmed by clinical observation in the first 36 months of the patient’s life. Clinical manifestations such as epilepsy, mental retardation, sleep disorders, hyperactivity, irritability and auto- and heteroaggressiveness may alter the patient’s prognosis. Around 50% of children with ASD fulfill the criteria for attention deficit hyperactivity disorder (ADHD). Symptoms of oppositional defiant disorder (ODD) associated with autism appear to indicate a distinct phenotype requiring specific therapeutic measures. ASD is not a discrete nosological entity but, rather, a multifactorial syndrome associated with different phenotypic and biological presentations. Various disorders such as pathologies of the gastrointestinal tract have been linked to ASD, not only insofar as causality is concerned but also with respect to their role in aggravating the disease. Other associated disorders include lesions in physiological processes such as the redox metabolism, mitochondrial dysfunction and enzymatic regulation of essential metabolites. Currently, studies on direct and indirect markers of mitochondrial metabolism associated with anomalies found in the brain of these patients point to the possibility of these markers being used as tools with which to reach a diagnosis that would be laboratory based rather than merely clinical.

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