Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity

2019 ◽  
Vol 33 (8) ◽  
pp. 775-785 ◽  
Author(s):  
Kongkai Zhu ◽  
Jingwei Shao ◽  
Hongrui Tao ◽  
Xue Yan ◽  
Cheng Luo ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Rational Design ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Triazole Derivatives ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of imidazopyridine–propenone conjugates as potent tubulin inhibitors

MedChemComm ◽  
2017 ◽  
Vol 8 (5) ◽  
pp. 1000-1006 ◽  
Author(s):  
Ibrahim Bin Sayeed ◽  
V. Lakshma Nayak ◽  
Mohd Adil Shareef ◽  
Neeraj Kumar Chouhan ◽  
Ahmed Kamal
Keyword(s):  
Antitumor Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Biological Evaluation ◽  
Human Cancer Cell ◽  
Design Synthesis ◽  
Human Cancer Cell Lines ◽  
Tubulin Inhibitors ◽  
Synthesis And Biological Evaluation

A library of imidazopyridine–propenone conjugates (8a–8u) were synthesized and evaluated for their antitumor activity against four human cancer cell lines.

Design, Synthesis, and Biological Evaluation of New Indole-Acrylamide-1,2,3-Triazole Derivatives as Potential α-Glucosidase Inhibitors

2020 ◽  
pp. 1-9
Author(s):  
Seyed Esmaeil Sadat-Ebrahimi ◽  
Hiva Babania ◽  
Maryam Mohammadi-Khanaposhtani ◽  
Mohammad Sadegh Asgari ◽  
Somayeh Mojtabavi ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Triazole Derivatives ◽  
Glucosidase Inhibitors ◽  
Synthesis And Biological Evaluation

Rational design, synthesis and biological evaluation of ubiquinone derivatives as IDO1 inhibitors

2019 ◽  
Vol 89 ◽  
pp. 102870 ◽  
Author(s):  
Yuyang Ding ◽  
Fei Tang ◽  
Xiaoqian Xue ◽  
Jinfeng Luo ◽  
Muzammal Hussain ◽  
...  
Keyword(s):  
Rational Design ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

α1-Adrenoceptor antagonists. rational design, synthesis and biological evaluation of new trazodone-like compounds

2002 ◽  
Vol 12 (3) ◽  
pp. 437-440 ◽  
Author(s):  
Laura Betti ◽  
Maurizio Botta ◽  
Federico Corelli ◽  
Monia Floridi ◽  
Paola Fossa ◽  
...  
Keyword(s):  
Rational Design ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
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