Based on grounded theory and combined with empirical investigation of self-organized entrepreneurial behavior, we explored the difference between male and female’s cognitive mode, cognitive bias and behavior influence. It is found that the cognitive pattern of self-organized female entrepreneurs is more narrow and obtrusive, but a few outstanding female entrepreneurs show outstanding performance. Self-organized male entrepreneurs show open and divergent structured cognition. On cognitive bias, women of ordinary self-organized entrepreneurs have a greater range of deviations. In terms of behavior influence, self-organized male entrepreneurs are strongly dependent on prior cognition due to their more emphasis on their professional and technological foundation, and their behavior is more persistent.