scholarly journals The biomechanical evaluation of magnetic forces to drive osteogenesis in newborn’s with cleft lip and palate

2020 ◽  
Vol 31 (9) ◽  
Author(s):  
Prasad Nalabothu ◽  
Carlalberta Verna ◽  
Markus Steineck ◽  
Andreas Albert Mueller ◽  
Michel Dalstra
Keyword(s):  
Cleft Lip ◽  
Load Transfer ◽  
Cleft Lip And Palate ◽  
Element Model ◽  
Bone Apposition ◽  
Magnetic Attraction ◽  
Distraction Device ◽  
Palatal Rugae ◽  
Biomechanical Evaluation ◽  
Set Up

Abstract This study examined the potential for dental magnets to act as a driving force for osteogenesis in the palate of newborns with a unilateral cleft lip and palate. In the first part of the study dental magnets were arranged in a set up mimicking a distraction device and the curves of the magnetic attraction force versus gap distance curves generated, with and without the presence of palatal rugae tissue in between both sides of the distraction device. The attraction forces ranged from 1 to 12 N depending on the gap distance and the presence of soft tissue in the gap. In the second part of the study these forces were used as input for a 3D finite element model of the palate of a newborn affected by unilateral cleft lip and palate. In the analysis of load transfer, it was found that the strains generated by a magnetically induced distraction exceed 1,500 µstrain suggesting that bone locally is submitted to mild overload leading to bone apposition.

scholarly journals Engineered mucoperiosteal scaffold for cleft palate regeneration towards the non-immunogenic transplantation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
M. I. Rizzo ◽  
L. Tomao ◽  
S. Tedesco ◽  
M. Cajozzo ◽  
M. Esposito ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Host Cells ◽  
Mesenchymal Precursor Cells ◽  
Set Up ◽  
Palate Bone ◽  
Palatal Bone ◽  
Molecular Resonance

AbstractCleft lip and palate (CL/P) is the most prevalent craniofacial birth defect in humans. None of the surgical procedures currently used for CL/P repair lead to definitive correction of hard palate bone interruption. Advances in tissue engineering and regenerative medicine aim to develop new strategies to restore palatal bone interruption by using tissue or organ-decellularized bioscaffolds seeded with host cells. Aim of this study was to set up a new natural scaffold deriving from a decellularized porcine mucoperiosteum, engineered by an innovative micro-perforation procedure based on Quantum Molecular Resonance (QMR) and then subjected to in vitro recellularization with human bone marrow-derived mesenchymal stem cells (hBM-MSCs). Our results demonstrated the efficiency of decellularization treatment gaining a natural, non-immunogenic scaffold with preserved collagen microenvironment that displays a favorable support to hMSC engraftment, spreading and differentiation. Ultrastructural analysis showed that the micro-perforation procedure preserved the collagen mesh, increasing the osteoinductive potential for mesenchymal precursor cells. In conclusion, we developed a novel tissue engineering protocol to obtain a non-immunogenic mucoperiosteal scaffold suitable for allogenic transplantation and CL/P repair. The innovative micro-perforation procedure improving hMSC osteogenic differentiation potentially impacts for enhanced palatal bone regeneration leading to future clinical applications in humans.

scholarly journals ORAL AND CRANIOFACIAL CHARACTERISTICS OF UNTREATED ADULT UNILATERAL CLEFT LIP AND PALATE INDIVIDUALS

2012 ◽  
Vol 02 (03) ◽  
pp. 16-20
Author(s):  
M. S. Ravi
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Sagittal Plane ◽  
Dental Morphology ◽  
Facial Morphology ◽  
Lateral Cephalogram ◽  
The Common ◽  
Set Up ◽  
The Individual ◽  
Craniofacial Characteristics

Abstract Introduction: Cleft lip and palate anomaly being the common congenital defect having significant effects on the facial morphology, function and growth and development of the individual, requires a detailed study of the Dental and craniofacial characteristics. Design and setting: The study is conducted in a hospital set up and the subjects were selected at random as per the inclusion criterion. Objectiveof study was to evaluate the craniofacial and Dental morphology in untreated unilateral cleft lip and palate (UCLP) individuals. Materials and Methods: A total of 64 individuals in the age group of 15-28 yrs were selected and grouped in to two groups; Cleft group consisting of 13 males and 19 females having untreated UCLP and another group of 16 male and 16female non cleft individuals. Study cast, lateral cephalogram and frontal cephalogram analysis were carried out .The obtained data were analyzed using ANOVA to compare the values between the groups. Result: Significant differences in cranio- facial characteristics were noted between the cleft and non cleft individuals. These differences were more pronounced in sagittal plane and less in transverse plane. Conclusion: Significant differences exist in the cranio- facial morphology between the untreated UCLP individuals and non cleft individuals.

Long-term Follow-up after Maxillary Distraction Osteogenesis in Growing Children with Cleft Lip and Palate

2007 ◽  
Vol 44 (3) ◽  
pp. 274-277 ◽  
Author(s):  
Chiung-Shing Huang ◽  
Pandurangan Harikrishnan ◽  
Yu-Fang Liao ◽  
Ellen W. C. Ko ◽  
Eric J. W. Liou ◽  
...  
Keyword(s):  
Distraction Osteogenesis ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
University Hospital ◽  
Anterior Nasal Spine ◽  
Distraction Device ◽  
Long Term Follow Up ◽  
The University ◽  
Maxillary Distraction

Objective: To evaluate the changes in maxillary position after maxillary distraction osteogenesis in six growing children with cleft lip and palate. Design: Retrospective, longitudinal study on maxillary changes at A point, anterior nasal spine, posterior nasal spine, central incisor, and first molar. Setting: The University Hospital Craniofacial Center. Main Outcome Measure: Cephalometric radiographs were used to measure the maxillary position immediately after distraction, at 6 months, and more than 1 year after distraction. Results: After maxillary distraction with a rigid external distraction device, the maxilla (A point) on average moved forward 9.7 mm and downward 3.5 mm immediately after distraction, moved backward 0.9 mm and upward 2.0 mm after 6 months postoperatively, and then moved further backward 2.3 mm and downward 6.8 mm after more than 1 year from the predistraction position. Conclusion: In most cases, maxilla moved forward at distraction and started to move backward until 1 year after distraction, but remained forward, as compared with predistraction position. Maxilla also moved downward during distraction and upward in 6 months, but started descending in 1 year. There also was no further forward growth of the maxilla after distraction in growing children with clefts.

International Confederation for Cleft Lip and Palate and Related Craniofacial Anomalies Task Force Report: Palatoplasty in the Speaking Individual with Unrepaired Cleft Palate

2014 ◽  
Vol 51 (6) ◽  
pp. 122-128 ◽  
Author(s):  
Brian C. Sommerlad
Keyword(s):  
Cleft Lip ◽  
Speech Therapy ◽  
Cleft Lip And Palate ◽  
Task Force ◽  
Special Importance ◽  
Older Children ◽  
Task Force Report ◽  
Palate Repair ◽  
Set Up ◽  
International Multicenter Study

Introduction The benefits or otherwise of late palate repair in older children or adults are uncertain. The outcomes, particularly without appropriate speech therapy, are often disappointing. The issue is of special importance in the poorer countries where these patients are most commonly seen and where limited capacity and facilities may have to be rationed. Method A task force was set up to report back to the International Congress in Orlando in May 2013. The chairman and some members were nominated by the organizers and further members were added during the discussion process. Some of the members had considerable experience of late palate repair. The task force compiled a report after 9 months of e-mail correspondence. The report includes reports of some previously unpublished studies. A summary of the report was presented at Cleft 2013 in Orlando. Conclusions There was a general consensus that late palate repair is of benefit for many patients and that, even if normal speech is not attained, outcomes are positive. Outcomes depend on the age of the patient (the younger the better), on the skill of the surgeon and, ideally, on the availability of appropriate speech therapy. A protocol for a prospective international multicenter study is proposed.

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