Exploring the mutual adaptive process of home-making and incremental upgrades in the context of Chile’s Progressive Housing Programme (1994–2016)

2019 ◽  
Vol 35 (1) ◽  
pp. 243-264
Author(s):  
Rodrigo Mora ◽  
Margarita Greene ◽  
Rebeca Gaspar ◽  
Pablo Moran
Keyword(s):  
Adaptive Process ◽  
Housing Programme

The Role of Reactive Oxygen Species, Kinases, Hydrogen Sulfide, and Nitric Oxide in the Regulation of Autophagy and Their Impact on Ischemia and Reperfusion Injury in the Heart

2020 ◽  
Vol 16 ◽  
Author(s):  
Andrey Krylatov ◽  
Leonid Maslov ◽  
Sergey Y. Tsibulnikov ◽  
Nikita Voronkov ◽  
Alla Boshchenko ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Hydrogen Sulfide ◽  
Ischemia Reperfusion ◽  
Reactive Oxygen ◽  
Ischemia And Reperfusion ◽  
Oxygen Species ◽  
Ischemia And Reperfusion Injury ◽  
Adaptive Process

: There is considerable evidence in the heart that autophagy in cardiomyocytes is activated by hypoxia/reoxygenation (H/R) or in hearts by ischemia/reperfusion (I/R). Depending upon the experimental model and duration of ischemia, increases in autophagy in this setting maybe beneficial (cardioprotective) or deleterious (exacerbate I/R injury). Aside from the conundrum as to whether or not autophagy is an adaptive process, it is clearly regulated by a number of diverse molecules including reactive oxygen species (ROS), various kinases, hydrogen sulfide (H2S) and nitric oxide (NO). The purpose this review is to address briefly the controversy regarding the role of autophagy in this setting and to examine a variety of disparate molecules that are involved in its regulation.

Lumiflavin Enhances the Effects of Ionising Radiation on Ovarian Cancer Stem-Like Cells by Inhibiting Autophagy

2021 ◽  
Vol 21 ◽  
Author(s):  
Meiyuan Wu ◽  
Yangsheng Huang ◽  
Zhaoxia Song ◽  
Ruhui Yang
Keyword(s):  
Ovarian Cancer ◽  
Ovarian Cancer Cell ◽  
Synergistic Effects ◽  
Ionising Radiation ◽  
Adaptive Process ◽  
Cell Vitality ◽  
Ovarian Cancer Cell Lines ◽  
Associated Proteins ◽  
Autophagy Pathway ◽  
Proliferation Ability

Background: The development of cancer stem-like cells (CSCs) is one of the main causes of ovarian cancer tolerance to radiotherapy. Autophagy is an adaptive process by which cells repair damage due to radiation. As a metabolite of riboflavin, lumiflavin can enhance the chemotherapeutic effects of cisplatin on ovarian cancer CSCs. Objective: This study aimed to investigate the synergistic effects of lumiflavin and ionising radiation on ovarian cancer CSCs and explore the association of this metabolite with autophagy. Methods: CSCs of human ovarian cancer cell lines HO8910 were treated with lumiflavin and rapamycin and then subjected to irradiation at a cumulative dose of 8 Gy. Cell proliferation ability, clonal formation ability, apoptosis rate, autophagy changes and autophagy-related protein changes were detected. Results: Lumiflavin and ionising radiation synergistically reduced cell vitality and clone formation and increased the apoptosis of CSCs compared with irradiation alone. In addition, ionising radiation increased autophagy and the expression of associated proteins, whereas lumiflavin reduced those changes in autophagy progression. Moreover, rapamycin, an autophagy inhibitor, was observed to block the synergistic effects of lumiflavin and ionising radiation on CSC apoptosis. Conclusion: Lumiflavin can enhance the effects of ionising radiation on ovarian cancer CSCs. The mechanism by which these effects are exerted is related to blocking the autophagy pathway.

Heuristic mining: Adaptive process simplification in education

2012 ◽  
Author(s):  
Nutchar Senewong Na Ayutaya ◽  
Prajin Palungsuntikul ◽  
Wichian Premchaiswadi
Keyword(s):  
Adaptive Process

scholarly journals Cerebrovascular Adaptation in Chronic Hydrocephalus

2001 ◽  
Vol 21 (3) ◽  
pp. 285-294 ◽  
Author(s):  
Mark G. Luciano ◽  
David J. Skarupa ◽  
Amy M. Booth ◽  
Arcangela S. Wood ◽  
Christine L. Brant ◽  
...  
Keyword(s):  
Occipital Cortex ◽  
Capillary Density ◽  
Vessel Diameter ◽  
Chronic Hydrocephalus ◽  
Short Term ◽  
Adaptive Process ◽  
Capillary Vessel ◽  
Hypoxic Environment ◽  
Luminal Area

This study characterizes the regional changes in vascularity, which accompanies chronic progressive hydrocephalus. Fifteen dogs underwent surgical induction of hydrocephalus and were used for histologic studies. Animals were divided into 4 groups: surgical control, short term (≤5 weeks), intermediate term ((8 weeks), and long term (10 to 12 weeks). Vessel diameter, density, and luminal area were calculated by imaging quantification after manual vessel identification in the cortical gray, white matter, and caudate nucleus. Capillary vessel diameter decreased 23.5% to 30.2% ( P < 0.01) in the caudate, but then returned to normal at 12 weeks. Capillary vessel density decreased 53.5% ( P < 0.05) in the cortical gray, but then increased to 234.8% ( P < 0.01) over surgical controls at 12 weeks. There was no initial decrease in capillary density in the caudate; however, the long-term group capillary density was significantly greater (172.8% to 210.5%, P < 0.01) than surgical controls. Overall, there was a short-term decrease in lumen area, with recovery in the longer term. Glial fibrillary acidic protein (GFAP) immunohistochemistry demonstrated the pattern of GFAP staining and reactive astrocytes differed in the caudate compared with the occipital cortex. This data suggest that an increase in capillary density and diameter may be an adaptive process allowing maintenance of adequate cerebral perfusion and metabolic support in the hypoxic environment of chronic hydrocephalus.

Numerical seismograms obtained using ω-κ integrals, for a point P source in a vertically inhomogeneous anelastic model

1996 ◽  
Vol 86 (3) ◽  
pp. 750-760
Author(s):  
F. Abramovici ◽  
L. H. T. Le ◽  
E. R. Kanasewich
Keyword(s):  
Half Space ◽  
Homogeneous Layer ◽  
Variable Step Size ◽  
Step Size ◽  
Adaptive Process ◽  
Cpu Time ◽  
Homogeneous Half Space ◽  
Linear Layer ◽  
Variable Step ◽  
Viscoelastic Layers

Abstract This article presents some numerical experiments in using a computer program for calculating the displacements due to a P source in a vertically inhomogeneous structure, based on the Fourier-Bessel representation. The structure may contain homogeneous, inhomogeneous, elastic, or viscoelastic layers. The source may act in any type of sublayer or in the half-space. Synthetic results for the simple case of a homogeneous layer overlaying a homogeneous half-space compare favorably with computations based on the Cagniard method. Numerical seismograms for an elastic layer having velocities and density varying linearly with depth were computed by integrating numerically the governing differential systems and compared with results based on the Haskell model of splitting the linear layer in homogeneous sublayers. Even an adaptive process with a variable step size based on the Haskell model has a poorer performance on the accuracy-cpu time scale than numerical integration.

Memory consolidation as an adaptive process

2021 ◽  
Author(s):  
Emily T. Cowan ◽  
Anna C. Schapiro ◽  
Joseph E. Dunsmoor ◽  
Vishnu P. Murty
Keyword(s):  
Memory Consolidation ◽  
Adaptive Process

scholarly journals Proposal of an Activity-Based Adaptive Process Model for Innovative Design

2013 ◽  
Author(s):  
Qiang Zhang ◽  
Ioana Deniaud ◽  
Claude Baron ◽  
Emmanuel Caillaud
Keyword(s):  
Process Model ◽  
Complex Adaptive System ◽  
Evaluation Methodology ◽  
Design Activity ◽  
Model Framework ◽  
Innovative Design ◽  
Adaptive Process ◽  
Complex Adaptive ◽  
Process Architecture ◽  
And Control

In this paper, we introduced an activity-based adaptive process model that views innovative design as a complex adaptive system. Instead of predefining the process architecture, we constructed the model framework by adaptively selecting the design activity by the activity value. We defined the activity value as the complexity reduction associated with the possibility of satisfying the design targets and design stages. Moreover, this paper contributes an expert evaluation methodology to evaluate the activity value in order to balance innovation and control. Finally, we applied the model to an industrial case and analyzed the simulation results.

scholarly journals Short-term saccadic adaptation in the macaque monkey: a binocular mechanism

2013 ◽  
Vol 109 (2) ◽  
pp. 518-545 ◽  
Author(s):  
K. P. Schultz ◽  
C. Busettini
Keyword(s):  
Saccadic Eye Movements ◽  
Initial Response ◽  
Macaque Monkey ◽  
Double Step ◽  
Adaptive Process ◽  
Adaptive Mechanisms ◽  
Second Shift ◽  
The Subject ◽  
The Brain ◽  
Saccadic Responses

Saccadic eye movements are rapid transfers of gaze between objects of interest. Their duration is too short for the visual system to be able to follow their progress in time. Adaptive mechanisms constantly recalibrate the saccadic responses by detecting how close the landings are to the selected targets. The double-step saccadic paradigm is a common method to simulate alterations in saccadic gain. While the subject is responding to a first target shift, a second shift is introduced in the middle of this movement, which masks it from visual detection. The error in landing introduced by the second shift is interpreted by the brain as an error in the programming of the initial response, with gradual gain changes aimed at compensating the apparent sensorimotor mismatch. A second shift applied dichoptically to only one eye introduces disconjugate landing errors between the two eyes. A monocular adaptive system would independently modify only the gain of the eye exposed to the second shift in order to reestablish binocular alignment. Our results support a binocular mechanism. A version-based saccadic adaptive process detects postsaccadic version errors and generates compensatory conjugate gain alterations. A vergence-based saccadic adaptive process detects postsaccadic disparity errors and generates corrective nonvisual disparity signals that are sent to the vergence system to regain binocularity. This results in striking dynamical similarities between visually driven combined saccade-vergence gaze transfers, where the disparity is given by the visual targets, and the double-step adaptive disconjugate responses, where an adaptive disparity signal is generated internally by the saccadic system.

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