Conceptions of Happiness Matter: Relationships between Fear and Fragility of Happiness and Mental and Physical Wellbeing

Author(s):  
L. Lambert ◽  
Z. A. Draper ◽  
M. A. Warren ◽  
M. Joshanloo ◽  
En-Ling Chiao ◽  
...  
Keyword(s):  
Author(s):  
Pasquale F. Innominato ◽  
David Spiegel

The circadian timing system temporally regulates biological functions relevant for psycho-physical wellbeing, spanning all the systems related to health. Hence, disruption of circadian rhythms, along with sleep cycles, is associated with the development of several diseases, including cancer. Moreover, altered circadian and sleep functions negatively impact on cancer patients’ quality of life and survival, above and beyond known determinants of outcome. This alteration can occur as a consequence of cancer, but also of anti-cancer treatments. Indeed, circadian rhythms govern also the ability of detoxifying chemotherapy agents across the 24 hours. Hence, adapting chemotherapy delivery to the molecular oscillations in relevant drug pathways can decrease toxicity to healthy cells, while increasing the number of cancer cells killing. This chronomodulated chemotherapy approach, together with the maintenance of proper circadian function throughtout the whole disease challenge, would finally result in safer and more active anticancer treatments, and in patients experiencing better quality and quantity of life.


2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e24031-e24031
Author(s):  
Ramon Mohanlal ◽  
Yvette Lelorier ◽  
Dominic Mitchell ◽  
Lan Huang ◽  
Douglas W. Blayney

e24031 Background: Plinabulin is a novel non-G-CSF small molecule being developed for the prevention of chemotherapy in conjunction with pegfilgrastim and is administered via 30 min IV infusion, 30 min after chemo on Day (D) 1. The QoL was analyzed using the Functional Assessment of Cancer Therapy - General questionnaire (FACT-G) as part of a phase 3 (Ph3) clinical trial comparing pegfilgrastim alone versus pegfilgrastim and plinabulin for the prevention of neutropenia in newly diagnosed breast cancer patients being treated with Docetaxel (75 mg/m2), Doxorubicin (50 mg/m2), and Cyclophosphamide (500 mg/m2) (TAC) on D1 for four 21 D cycles and study treatment. Methods: The FACT-G was administered to patients in China and Ukraine using an ePRO app downloaded onto patients' phones as part of the Phase 3 PROTECTIVE-2 trial (NCT0329457) with TAC. Patients completed the FACT-G during each chemo cycle at D-1, D1, D8 and D15. Patients received reminders 1 hour before the required completion time and all entries were time stamped. The FACT-G measured the impact of cancer on four categories: Physical wellbeing, Social wellbeing, Emotional wellbeing and Functional wellbeing. Results: Compared to pegfilgrastim alone, patients on plinabulin + pegfilgrastim performed significantly better for Physical wellbeing on D8 and D15 of Cycle 2 (p < 0.0589 and p < 0.0039 respectively) and Cycle 3 (p < 0.0360 and p < 0.0343 respectively). Further analysis of the sub questions showed that both energy levels “I have a lack of energy” and pain”(I have pain” were significantly better for the plinabulin + pegfilgrastim combination versus pegfilgrastim alone (p < 0.0377 and p < 0.0420 respectively). Overall FACT-G completion compliance for the trial was 91%. Conclusions: The Physical wellbeing (in particular, pain and for energy levels) of patients receiving plinabulin in combination with pegfilgrastim for the prevention of TAC CIN, was significantly less impacted by chemo dosing compared to the pegfilgrastim alone arm. In addition, the results suggest that patients receiving the combination therapy recovered their pre-chemo Physical wellbeing levels more rapidly. Clinical trial information: NCT03531099.


2016 ◽  
Vol 21 (4) ◽  
pp. 1137-1144 ◽  
Author(s):  
Cristina Nunes ◽  
Ángel Hernando ◽  
Ida Lemos ◽  
Lara Ayala-Nunes ◽  
Cristina Romero Oliva ◽  
...  

Abstract The aim of this study was to analyse differences in quality of life (QOL) between Spanish and Portuguese immigrant and native adolescents. In total, 475 native and immigrant adolescents (52% boys) from Algarve (Portugal) and Huelva (Spain), aged between 12 and 17 years old, were assessed with the KIDSCREEN-52. QOL dimensions were not related to most academic variables, with the exception of number of school failures, Financial Resources and Social Support from Peers. Multivariate analysis of variance (MANOVA) was used to examine statistical differences in adolescents QOL. Age differences in QOL levels were not found. Girls reported worse QOL levels on Physical Wellbeing than boys (F = 10.32, p = .001, η2 =.02). Immigrant Portuguese adolescents scored higher on Mood (F = 17.57, p = .000, η2 =.11), and native Portuguese adolescents scored higher on Social Acceptance (F = 4.87, p = .002, η2 =.033). Immigrant and native adolescents had similar levels of perceived QOL. Overall, it seems that in both countries, the living contexts for immigrant and native adolescents are fairly homogeneous.


Author(s):  
Madonna Harrington Meyer ◽  
Ynesse Abdul-Malak
Keyword(s):  

2015 ◽  
Vol 2 (2) ◽  
Author(s):  
Urvashi Sharma ◽  
Dr. Ravindra Kumar

Health is a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity. Mental health refers to our overall psychological well-being. It includes the way we feel about our self, the quality of our relationships, and our ability to manage our feelings and deal with difficulties. Good mental health isn’t just the absence of mental health problems. People who are emotionally or mentally healthy are in control of their emotions and their behavior. They are able to handle life’s challenges, build strong relationships, and recover from setbacks. Positive mental health is a state of well-being in which we realize our abilities, can cope with life’s normal stresses, and can work regularly and productively. Physical health means a good body health, which is healthy because of regular physical activity, good nutrition, and adequate rest. Physical health can be determined by considering someone’s height/weight ratio, their Body Mass Index. Another term for physical health is physical wellbeing. Physical wellbeing is defined as something a person can achieve by developing all health-related components of his/her lifestyle. It can be concluded that mental and physical health is fundamentally linked. There are multiple associations between mental health and chronic physical conditions that significantly impact people’s quality of life. Just as physical fitness helps our bodies to stay strong, mental fitness helps us to achieve and sustain a state of good mental health. When we are mentally healthy, we enjoy our life and environment, and the people in it.


2019 ◽  
pp. 91-97

Análisis de las actitudes hacia la actividad minera en la comunidad de Combayo, región Cajamarca Analysis of attitudes towards the mining activity in Combayo’s community, Cajamarca Region Jorge L. Vásquez pacheco Universidad Inca Garcilaso de la Vega Empresa de Servicios Organizacionales, Educativos y Comunitarios Green planet DOI: https://doi.org/10.33017/RevECIPeru2010.0026/ RESUMEN Estudio de tipo descriptivo que aplica la metodología transversal mediante una escala original de actitudes, tipo Likert, compuesta inicialmente de 32 reactivos, reducidos a 29 ítems tras el análisis estadístico por medio de la correlación item-test. Dicha escala obtuvo un coeficiente Alfa de Cronbach de ,938, determinando así su consistencia y su validez para el propósito del presente estudio. Los participantes fueron 120 pobladores oriundos de la comunidad de Combayo, región Cajamarca, cuyas edades fluctuaban entre 18 a 60 años (hombres y mujeres), elegidos al azar. No se dio preferencia a uno u otro sexo y todas las dudas fueron resueltas de manera personalizada. Asimismo, tras la aplicación del instrumento se realizaron entrevistas breves a un subgrupo (30) elegido de manera aleatoria con el fin de complementar y contrastar la información obtenida y conocer así si el comunero de Combayo fundamenta la posición que asume. Se obtuvieron cinco factores: calidad de vida, desarrollo comunal, prospección comunal, bienestar psicológico y bienestar físico, cuyos indicadores han permitido establecer los niveles de aprobación respecto a la actividad minera, con los siguientes resultados: para el 80%, la actividad minera es desfavorable; para el 14%, la actividad minera es favorable; mientras que para el 6%, la influencia de la actividad minera le resulta neutral. Se concluye que a pesar de la actitud desfavorable hacia la actividad minera en su comunidad, los pobladores la aceptan a nivel conductual, pues mediante las entrevistas se pudo conocer que en general percibían que dicha actividad podía contribuir a su bienestar pero a costa de su calidad de vida (primer factor), siendo mayor la consideración (puntajes de las medias aritméticas) que tienen respecto al desarrollo de su comunidad (segundo factor), la prospección comunal (tercer factor), el bienestar psicológico (cuarto factor) y el bienestar físico (quinto factor). Sin embargo, dicha consideración disminuye respecto a factores contribuyentes a mejorar su calidad de vida. De esta expresión se puede notar que los comuneros de Combayo tienen mayor interés por la obtención de resultados a corto plazo y de satisfacción inmediata respecto a los beneficios que esperan obtener del desarrollo de actividades mineras en su comunidad, lo cual evidencia la presencia de una disonancia cognitiva en dicha comunidad, puesto que estarían reconociendo sus necesidades y también el costo de satisfacer las mismas. Descriptores: actitud, actividad minera, comunidad, disonancia cognitiva. ABSTRACT This is a descriptive study that applies a cross research methodology through the application of an original scale of attitudes, likert like, composed originally of 32 reagents, reduced to 29 items after the statistical analysis through the item-test correlation. The scale obtained a cronbach alpha coefficient of, 938 thereby determining the consistency and validity for the purpose of this study. The participants were 120 people natives from the combayo’s community, region cajamarca, ranging in age from 18 to 60 years (men and women) selected randomly. no preference was given to any gender and all doubts were resolved in an individual manner. also, after application of the instrument brief interviews were conducted with a subgroup (30) randomly chosen in order to complement and contrast the information obtained, thus disclosing whether the villager from combayo has a basis for the position taken. We looked into five factors: Quality of life, community development, community prospecting, psychological wellbeing, and physical wellbeing. Where indicators serve to establish approval levels on mining, with the following results: For 80% of the subjects mining is unfavorable, for 14% of the subjects mining is favorable, and for 6% of the subjects the influence of mining is neutral. We conclude that despite the negative attitude towards mining in this community, residents accept it since they generally perceived that this activity could contribute to their welfare but at the cost of their quality of life (First Factor), but it is of their greater consideration (scores of arithmetic mean) the development of their community (second factor), the communal prospects (third factor), the psychological wellbeing (fourth factor), and physical wellbeing (Fifth Factor). nevertheless, such consideration falls on contributing to improve their quality of life. one can see that the commoners of combayo are more interested in obtaining short-term results and immediate satisfaction regarding the benefits expected from the development of mining activities in their community, which shows the presence of cognitive dissonance in that community since they would be recognizing their needs and also the cost of meeting them. Keywords: attitude, mining activity, community, cognitive dissonance.


2011 ◽  
Vol 5 (8) ◽  
pp. 370-370
Author(s):  
Tanis Hand
Keyword(s):  

Author(s):  
Joseph Keawe‘aimoku Kaholokula ◽  
Andrea H. Hermosura ◽  
Mapuana C.K. Antonio

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