Model-based meta-analysis for development of a population-pharmacokinetic (PPK) model for Vitamin D3 and its 25OHD3 metabolite using both individual and arm-level data

2016 ◽  
Vol 43 (2) ◽  
pp. 191-206 ◽  
Author(s):  
Alanna S. Ocampo-Pelland ◽  
Marc R. Gastonguay ◽  
Jonathan F. French ◽  
Matthew M. Riggs
Keyword(s):  
Vitamin D3 ◽  
Meta Analysis ◽  
Population Pharmacokinetic ◽  
Model Based ◽  
Level Data

DO WE HAVE A CONSENSUS TO APPLY MODEL-BASED AMINOGLYCOSIDE THERAPY: A REVIEW OF POPULATION PHARMACOKINETIC MODELS

2015 ◽  
Vol 101 (1) ◽  
pp. e1.51-e1
Author(s):  
Guo-Xiang Hao ◽  
Sophie Teng ◽  
Evelyne Jacqz-Aigrain ◽  
Wei Zhao
Keyword(s):  
Meta Analysis ◽  
Pharmacokinetic Modeling ◽  
Pharmacokinetic Parameters ◽  
Population Pharmacokinetic ◽  
Pharmacokinetic Models ◽  
Related Factors ◽  
Model Based ◽  
Aminoglycoside Therapy ◽  
Bibliographic Search ◽  
Adults And Children

Background and ObjectiveAminoglycosides remain the standard antibiotic therapy for Gram-negative infections in both adults and children. The pharmacokinetic modeling approach has been widely used to evaluate aminoglycosides therapy. The aim of the present study is to review the published population pharmacokinetic models of commonly used aminoglycosides (gentamycin, amikacin and tobramycin), in order to determine if there was a consensus to apply model-based personalized aminoglycoside therapy in routine clinical practice.MethodsThe bibliographic search was performed electronically using PubMed on 30th January 2015, following the search strategy: “((population Pharmacokinetics) OR (Pharmacokinetic modeling)) AND (gentamycin OR gentamicin OR amikacin OR tobramycin)”.ResultsA total of 49 articles were identified. Persistent variabilities exist in terms of structure model; typical pharmacokinetic parameters and identified covariates.ConclusionA pharmacokinetic meta-analysis is required to evaluate the study-related factors influencing the pharmacokinetics of aminoglycosides. A clinical evaluation of pharmacokinetic model of aminoglycosides is required to demonstrate its clinical utility.

Asking More than Where: Developing a Site Contextual Model Based on Reconstructing past Environments

1997 ◽  
Vol 17 (4) ◽  
pp. 307-336
Author(s):  
Douglas S. Frink
Keyword(s):  
Native American ◽  
Phase I ◽  
Contextual Model ◽  
Model Based ◽  
European Settlement ◽  
Level Data ◽  
Limited Application ◽  
And Function ◽  
A Site ◽  
Phase Ii And Iii

Contract archaeology accounts for the majority of archaeological studies conducted in Vermont. As these studies serve the development community, the focus of investigation has been to identify and avoid sites, not to research and evaluate the information they contain. Native-American site locational models have limited application because they are based primarily on the landforms' proximity to water. The Archaeology Consulting Team is developing a contextual model based on reconstructing the pre-European settlement environment. Hypotheses comparing expected size and function of Native-American sites in different environments can be posed at the Phase I level of archaeological studies. Furthermore, with Phase I level data, these hypotheses can provide the framework for research designs at Phase II and III levels of archaeological study.

scholarly journals A Population Pharmacokinetic Meta‐analysis of Veliparib, a PARP Inhibitor, Across Phase I/II/III Trials in Cancer Patients

2021 ◽  
Author(s):  
Sven Stodtmann ◽  
Silpa Nuthalapati ◽  
Doerthe Eckert ◽  
Sreeneeranj Kasichayanula ◽  
Rujuta Joshi ◽  
...  
Keyword(s):  
Phase I ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Parp Inhibitor ◽  
Population Pharmacokinetic

A model-based meta-analysis of the influence of factors that impact adherence to medications

2014 ◽  
Vol 40 (1) ◽  
pp. 24-31 ◽  
Author(s):  
P. Assawasuwannakit ◽  
R. Braund ◽  
S. B. Duffull
Keyword(s):  
Meta Analysis ◽  
Model Based

scholarly journals An Integrated Population Pharmacokinetic Meta-Analysis of Propofol in Morbidly Obese and Nonobese Adults, Adolescents, and Children

2013 ◽  
Vol 2 (9) ◽  
pp. 73 ◽  
Author(s):  
J Diepstraten ◽  
V Chidambaran ◽  
S Sadhasivam ◽  
HJ Blussé van Oud-Alblas ◽  
T Inge ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Morbidly Obese ◽  
Population Pharmacokinetic

scholarly journals Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis

PLoS Medicine ◽  
2017 ◽  
Vol 14 (1) ◽  
pp. e1002212 ◽  
Author(s):  
Richard M. Hoglund ◽  
Lesley Workman ◽  
Michael D. Edstein ◽  
Nguyen Xuan Thanh ◽  
Nguyen Ngoc Quang ◽  
...  
Keyword(s):  
Falciparum Malaria ◽  
Meta Analysis ◽  
Population Pharmacokinetic ◽  
Individual Participant Data ◽  
Pharmacokinetic Properties ◽  
Individual Participant

scholarly journals Short‐Term Efficacy Reliably Predicts Long‐Term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model‐Based Meta‐Analysis

2015 ◽  
Vol 56 (7) ◽  
pp. 835-844 ◽  
Author(s):  
Yehong Wang ◽  
Rui Zhu ◽  
Jim Xiao ◽  
John C. Davis ◽  
Jaap W. Mandema ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trials ◽  
Clinical Benefit ◽  
Meta Analysis ◽  
Short Term ◽  
Model Based ◽  
Term Efficacy

scholarly journals A model-based correction for outcome reporting bias in meta-analysis

Biostatistics ◽  
2013 ◽  
Vol 15 (2) ◽  
pp. 370-383 ◽  
Author(s):  
J. Copas ◽  
K. Dwan ◽  
J. Kirkham ◽  
P. Williamson
Keyword(s):  
Meta Analysis ◽  
Reporting Bias ◽  
Outcome Reporting Bias ◽  
Outcome Reporting ◽  
Model Based
Sign in / Sign up

Export Citation Format

Share Document