scholarly journals Head and Neck Squamous Cell Carcinoma: Risk Factors, Molecular Alterations, Immunology and Peptide Vaccines

2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Zhe Sun ◽  
Xiaodong Sun ◽  
Zhanwei Chen ◽  
Juan Du ◽  
Yihua Wu
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Peptide Vaccines ◽  
Molecular Alterations ◽  
Carcinoma Risk

scholarly journals Role of Phosphatidylinositol-3-Kinase Pathway in Head and Neck Squamous Cell Carcinoma

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Li Du ◽  
Jingping Shen ◽  
Andrew Weems ◽  
Shi-Long Lu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Pi3k Pathway ◽  
Neck Squamous Cell Carcinoma ◽  
Phosphatidylinositol 3 Kinase ◽  
Molecular Alterations ◽  
Future Direction ◽  
Phosphatidylinositol 3

Activation of the phosphatidylinositol-3-kinase (PI3K) pathway is one of the most frequently observed molecular alterations in many human malignancies, including head and neck squamous cell carcinoma (HNSCC). A growing body of evidence demonstrates the prime importance of the PI3K pathway at each stage of tumorigenesis, that is, tumor initiation, progression, recurrence, and metastasis. Expectedly, targeting the PI3K pathway yields some promising results in both preclinical studies and clinical trials for certain cancer patients. However, there are still many questions that need to be answered, given the complexity of this pathway and the existence of its multiple feedback loops and interactions with other signaling pathways. In this paper, we will summarize recent advances in the understanding of the PI3K pathway role in human malignancies, with an emphasis on HNSCC, and discuss the clinical applications and future direction of this field.

Polymorphisms of the CYP1A1 and CYP2E1 genes in head and neck squamous cell carcinoma risk

2011 ◽  
Vol 39 (2) ◽  
pp. 1055-1063 ◽  
Author(s):  
Nathália Moreno Cury ◽  
Anelise Russo ◽  
Ana Lívia Silva Galbiatti ◽  
Mariângela Torreglosa Ruiz ◽  
Luiz Sérgio Raposo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Carcinoma Risk

Polymorphisms and haplotypes in methylenetetrahydrofolate reductase gene and head and neck squamous cell carcinoma risk

2011 ◽  
Vol 39 (1) ◽  
pp. 635-643 ◽  
Author(s):  
Ana Lívia Silva Galbiatti ◽  
Mariangela Torreglosa Ruiz ◽  
Juliana Olsen Rodrigues ◽  
Luiz Sérgio Raposo ◽  
José Victor Maníglia ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Methylenetetrahydrofolate Reductase ◽  
Neck Squamous Cell Carcinoma ◽  
Reductase Gene ◽  
Carcinoma Risk ◽  
Methylenetetrahydrofolate Reductase Gene

MTHFD1 G1958A, BHMT G742A, TC2 C776G and TC2 A67G polymorphisms and head and neck squamous cell carcinoma risk

2011 ◽  
Vol 39 (2) ◽  
pp. 887-893 ◽  
Author(s):  
Lidia Maria Rebolho Batista da Silva ◽  
Ana Lívia Silva Galbiatti ◽  
Mariangela Torreglosa Ruiz ◽  
Luiz Sérgio Raposo ◽  
José Victor Maniglia ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Carcinoma Risk
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