DNA damage and oxidative stress induced by seizures are decreased by anticonvulsant and neuroprotective effects of lobeline, a candidate to treat alcoholism

2017 ◽  
Vol 33 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Liana Dantas da Costa e Silva ◽  
Patrícia Pereira ◽  
Gabriela Gregory Regner ◽  
Fernanda Brião Menezes Boaretto ◽  
Cleonice Hoffmann ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Neuroprotective Effects ◽  
And Oxidative Stress

Styrax camporum, a typical species of the Brazilian cerrado, attenuates DNA damage, preneoplastic lesions and oxidative stress in experimental rat colon carcinogenesis

2021 ◽  
pp. 1-11
Author(s):  
Pollyanna Francielli De Oliveira ◽  
Luis Fernando Leandro ◽  
Ricardo Andrade Furtado ◽  
Natália Helen Ferreira ◽  
Patrícia Mendonça Pauletti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Colon Carcinogenesis ◽  
Rat Colon ◽  
Brazilian Cerrado ◽  
Preneoplastic Lesions ◽  
Typical Species ◽  
And Oxidative Stress

Haloperidol-loaded lipid-core polymeric nanocapsules reduce DNA damage in blood and oxidative stress in liver and kidneys of rats

2015 ◽  
Vol 17 (4) ◽  
Author(s):  
Katiane Roversi ◽  
Dalila M. Benvegnú ◽  
Karine Roversi ◽  
Fabíola Trevizol ◽  
Luciana T. Vey ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Lipid Core ◽  
Polymeric Nanocapsules ◽  
And Oxidative Stress

O XVII B.2 Determination of endogenous DNA damage, oxidated DNA bases and oxidative stress in primary human colon cells and modulation by plant ingredients

1997 ◽  
Vol 379 (1) ◽  
pp. S171
Author(s):  
Beatrice L. Pool-Zobel ◽  
Salomon L. Abrahamse ◽  
Daniela Oberreuther ◽  
Sylvia Treptow-van Lishaut ◽  
Gerhard Rechkemmer
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Human Colon ◽  
Dna Bases ◽  
Colon Cells ◽  
And Oxidative Stress

scholarly journals Occupational hazards, DNA damage, and oxidative stress on exposure to waste anesthetic gases

2018 ◽  
Vol 68 (1) ◽  
pp. 33-41
Author(s):  
Lorena M.C. Lucio ◽  
Mariana G. Braz ◽  
Paulo do Nascimento Junior ◽  
José Reinaldo C. Braz ◽  
Leandro G. Braz
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Occupational Hazards ◽  
Anesthetic Gases ◽  
And Oxidative Stress

Effects of Ambient Atmospheric PM2.5, 1-Nitropyrene and 9-Nitroanthracene on DNA Damage and Oxidative Stress in Hearts of Rats

2018 ◽  
Vol 19 (2) ◽  
pp. 178-190 ◽  
Author(s):  
Lifang Zhao ◽  
Li Zhang ◽  
Minghui Chen ◽  
Chuan Dong ◽  
Ruijin Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
And Oxidative Stress ◽  
Atmospheric Pm2.5

Perinatal Exposure to the Cyanotoxin β-N-Méthylamino-l-Alanine (BMAA) Results in Long-Lasting Behavioral Changes in Offspring—Potential Involvement of DNA Damage and Oxidative Stress

2017 ◽  
Vol 33 (1) ◽  
pp. 87-112 ◽  
Author(s):  
Anthony Laugeray ◽  
Asma Oummadi ◽  
Clément Jourdain ◽  
Justyne Feat ◽  
Géraldine Meyer-Dilhet ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Behavioral Changes ◽  
Perinatal Exposure ◽  
And Oxidative Stress

Effects of Amaranthus cruentus L. on aflatoxin B1- and oxidative stress-induced DNA damage in human liver (HepG2) cells

2018 ◽  
Vol 26 ◽  
pp. 42-48 ◽  
Author(s):  
Grace A. Odongo ◽  
Nina Schlotz ◽  
Susanne Baldermann ◽  
Susanne Neugart ◽  
Benard Ngwene ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Aflatoxin B1 ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Amaranthus Cruentus ◽  
And Oxidative Stress

Aging and oxidative stress alter DNA repair mechanisms in male germ cells of superoxide dismutase-1 null mice

2021 ◽  
Author(s):  
Paulina Nguyen-Powanda ◽  
Bernard Robaire
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Dna Repair ◽  
Superoxide Dismutase ◽  
Germ Cells ◽  
Superoxide Dismutase 1 ◽  
Male Germ Cells ◽  
Dna Repair Mechanisms ◽  
Repair Mechanisms ◽  
And Oxidative Stress

Abstract The efficiency of antioxidant defense system decreases with aging, thus resulting in high levels of reactive oxygen species (ROS) and DNA damage in spermatozoa. This damage can lead to genetic disorders in the offspring. There are limited studies investigating the effects of the total loss of antioxidants, such as superoxide dismutase-1 (SOD1), in male germ cells as they progress through spermatogenesis. In this study, we evaluated the effects of aging and removing SOD1 (in male germ cells of SOD1-null (Sod1−/−) mice) in order to determine the potential mechanism(s) of DNA damage in these cells. Immunohistochemical analysis showed an increase in lipid peroxidation and DNA damage in the germ cells of aged wild-type (WT) and Sod1−/− mice of all age. Immunostaining of OGG1, a marker of base excision repair (BER), increased in aged WT and young Sod1−/− mice. In contrast, immunostaining intensity of LIGIV and RAD51, markers of non-homologous end-joining (NHEJ) and homologous recombination (HR), respectively, decreased in aged and Sod1−/− mice. Gene expression analysis showed similar results with altered mRNA expression of these key DNA repair transcripts in pachytene spermatocytes and round spermatids of aged and Sod1−/− mice. Our study indicates that DNA repair pathway markers of BER, NHEJ, and HR are differentially regulated as a function of aging and oxidative stress in spermatocytes and spermatids, and aging enhances the repair response to increased oxidative DNA damage, whereas impairments in other DNA repair mechanisms may contribute to the increase in DNA damage caused by aging and the loss of SOD1.

Sign in / Sign up

Export Citation Format

Share Document