Effects of tetrahydrocannabinol treatment on brain metabolism and neuron loss in a mouse model of sporadic Alzheimer's disease

2019 ◽  
Author(s):  
TN Franke ◽  
C Irwin ◽  
N Beindorff ◽  
Y Bouter ◽  
C Bouter
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Brain Metabolism ◽  
Sporadic Alzheimer’S Disease ◽  
Neuron Loss

A multifunctional compound ebselen reverses memory impairment, apoptosis and oxidative stress in a mouse model of sporadic Alzheimer's disease

2019 ◽  
Vol 109 ◽  
pp. 107-117 ◽  
Author(s):  
Franciele Martini ◽  
Suzan Gonçalves Rosa ◽  
Isabella Pregardier Klann ◽  
Bruna Cruz Weber Fulco ◽  
Fabiano Barbosa Carvalho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Memory Impairment ◽  
Sporadic Alzheimer’S Disease ◽  
And Oxidative Stress

scholarly journals Chronic Memantine Treatment Ameliorates Behavioral Deficits, Neuron Loss, and Impaired Neurogenesis in a Model of Alzheimer’s Disease

2020 ◽  
Vol 58 (1) ◽  
pp. 204-216
Author(s):  
Martina Stazi ◽  
Oliver Wirths
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Recognition Task ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Behavioral Deficits ◽  
Neuron Loss ◽  
Beneficial Effects ◽  
Memantine Treatment

AbstractMemantine, a non-competitive NMDA receptor antagonist possessing neuroprotective properties, belongs to the small group of drugs which have been approved for the treatment of Alzheimer’s disease (AD). While several preclinical studies employing different transgenic AD mouse models have described beneficial effects with regard to rescued behavioral deficits or reduced amyloid plaque pathology, it is largely unknown whether memantine might have beneficial effects on neurodegeneration. In the current study, we assessed whether memantine treatment has an impact on hippocampal neuron loss and associated behavioral deficits in the Tg4-42 mouse model of AD. We demonstrate that a chronic oral memantine treatment for 4 months diminishes hippocampal CA1 neuron loss and rescues learning and memory performance in different behavioral paradigms, such as Morris water maze or a novel object recognition task. Cognitive benefits of chronic memantine treatment were accompanied by an amelioration of impaired adult hippocampal neurogenesis. Taken together, our results demonstrate that memantine successfully counteracts pathological alterations in a preclinical mouse model of AD.

scholarly journals Hippocampal Neuron Loss Exceeds Amyloid Plaque Load in a Transgenic Mouse Model of Alzheimer's Disease

2004 ◽  
Vol 164 (4) ◽  
pp. 1495-1502 ◽  
Author(s):  
Christoph Schmitz ◽  
Bart P.F. Rutten ◽  
Andrea Pielen ◽  
Stephanie Schäfer ◽  
Oliver Wirths ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Hippocampal Neuron ◽  
Amyloid Plaque ◽  
Transgenic Mouse Model ◽  
Neuron Loss ◽  
Model Of Alzheimer’S Disease ◽  
Plaque Load

O1-03-03: Microglia mediated and fractalkine receptor dependent neuron loss in a mouse model of Alzheimer's disease

2009 ◽  
Vol 5 (4S_Part_3) ◽  
pp. P82-P82 ◽  
Author(s):  
Martin Fuhrmann ◽  
Tobias Bittner ◽  
Christian Jung ◽  
Steffen Burgold ◽  
Gerda Mitteregger ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Neuron Loss ◽  
Fractalkine Receptor ◽  
Model Of Alzheimer’S Disease

scholarly journals Deuterium-reinforced polyunsaturated fatty acids improve cognition in a mouse model of sporadic Alzheimer's disease

FEBS Journal ◽  
2017 ◽  
Vol 284 (23) ◽  
pp. 4083-4095 ◽  
Author(s):  
Ahmed Elharram ◽  
Nicole M. Czegledy ◽  
Michael Golod ◽  
Ginger L. Milne ◽  
Erik Pollock ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Mouse Model ◽  
Polyunsaturated Fatty Acids ◽  
Sporadic Alzheimer’S Disease
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