Maternal embryonic leucine zipper kinase serves as a potential prognostic marker and leads to sorafenib chemoresistance modified by miR-142-5p in hepatocellular carcinoma

2022 ◽  
Author(s):  
Hualei Li ◽  
Ling Gai ◽  
Zhimei Wu ◽  
Feng Li
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Marker ◽  
Leucine Zipper

Potential of alpha-fetoprotein as a prognostic marker after curative radiofrequency ablation of hepatocellular carcinoma

2016 ◽  
Vol 46 (9) ◽  
pp. 916-923 ◽  
Author(s):  
Chihiro Dohi ◽  
Kazuhiro Nouso ◽  
Koji Miyahara ◽  
Yuki Morimoto ◽  
Nozomu Wada ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Prognostic Marker ◽  
Alpha Fetoprotein

scholarly journals Methylation of S100A8 is a promising diagnosis and prognostic marker in hepatocellular carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (35) ◽  
pp. 56798-56810 ◽  
Author(s):  
Kun Liu ◽  
Yuening Zhang ◽  
Chengdong Zhang ◽  
Qinle Zhang ◽  
Jiatong Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Marker

scholarly journals Low miR-29c expression is a prognostic marker in hepatocellular carcinoma

2016 ◽  
Vol 15 (3) ◽  
Author(s):  
C.W. Dong ◽  
Y.X. Wang ◽  
F.T. Du ◽  
W. Ding ◽  
S.Y. Hu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Marker

scholarly journals MafF Is Regulated via the circ-ITCH/miR-224-5p Axis and Acts as a Tumor Suppressor in Hepatocellular Carcinoma

2020 ◽  
Vol 28 (3) ◽  
pp. 299-309 ◽  
Author(s):  
Minhua Wu ◽  
Xubin Deng ◽  
Yu Zhong ◽  
Li Hu ◽  
Xiujuan Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Suppressor ◽  
Leucine Zipper ◽  
Circular Rna ◽  
Luciferase Assay ◽  
Bzip Transcription Factor ◽  
Regulation Mechanism ◽  
Antitumor Effects ◽  
Basic Leucine Zipper ◽  
New Perspective

MafF is a member of the basic leucine zipper (bZIP) transcription factor Maf family and is commonly downregulated in multiple cancers. But the expression and function of MafF in hepatocellular carcinoma (HCC) remain unclear. In this study, we investigated the relationship between endogenous MafF expression and HCC progression and explored the regulatory mechanism of MafF expression in HCC. We found that MafF decreased in HCC tissues and cells. Lentivirus-mediated MafF overexpression inhibited HCC cell proliferation and induced cell apoptosis. Bioinformatics analysis and luciferase assay identified MafF as a direct target of miR-224-5p. RNA pull-down assay demonstrated that circular RNA circ-ITCH could sponge miR-224-5p specifically in HCC. The rescue experiments further elucidated that the expression and antitumor effects of MafF could be regulated via the circ-ITCH/miR-224-5p axis. This study verified that MafF acted as a tumor suppressor in HCC and revealed the upstream regulation mechanism of MafF, which provided a new perspective for potential therapeutic targets of HCC.

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