BRAF V600E mutation is a useful marker for differentiating Rathke’s cleft cyst with squamous metaplasia from papillary craniopharyngioma

2015 ◽  
Vol 123 (1) ◽  
pp. 189-191 ◽  
Author(s):  
Jang-Hee Kim ◽  
Werner Paulus ◽  
Stephanie Heim
Keyword(s):  
Squamous Metaplasia ◽  
Braf V600e Mutation ◽  
Braf V600e ◽  
Rathke’S Cleft Cyst ◽  
Rathke's Cleft Cyst ◽  
Rathke's Cleft

scholarly journals Craniopharyngioma arising in a Rathke's cleft cyst: case report

2015 ◽  
Vol 15 (3) ◽  
pp. 250-254 ◽  
Author(s):  
Ahmed K. Alomari ◽  
Brian J. Kelley ◽  
Eyiyemisi Damisah ◽  
Asher Marks ◽  
Pei Hui ◽  
...  
Keyword(s):  
Squamous Metaplasia ◽  
Molecular Classification ◽  
Beta Catenin ◽  
Rathke’S Cleft Cyst ◽  
Rathke's Cleft Cyst ◽  
Ki 67 ◽  
Patient Will ◽  
Rim Enhancement ◽  
Rathke's Cleft ◽  
Sellar Lesion

Craniopharyngioma is one of the most common non-glial intracranial tumors of childhood. Its relation to Rathke's cleft cyst (RCC) is controversial, and both lesions have been hypothesized to lie on a continuum of cystic ectodermal lesions of the sellar region. The authors report on a 7-year-old boy who presented with decreased visual acuity, presumably of at least 2 years' duration, and was found to have a 5.2-cm sellar lesion with rim enhancement. Histological examination of the resected lesion showed a mixture of areas with simple RCC morphology with focal squamous metaplasia and areas with typical craniopharyngioma morphology. Immunohistochemical staining with CK20 and Ki 67 differentially highlighted the 2 morphological components. Testing for beta-catenin and BRAF mutations was negative in the craniopharyngioma component, precluding definitive molecular classification. Follow-up imaging showed minimal residual enhancement and the patient will be closely followed up with serial MRI. Given the clinical and histological findings in the case, a progressive transformation of the RCC to craniopharyngioma seems to be the most plausible explanation for the co-occurrence of the 2 lesion types in this patient. An extensive review of previously proposed theories of the relationship between craniopharyngioma and RCC is also presented.

scholarly journals A Rare Case of Rathke’s Cleft Cyst Apoplexy

2021 ◽  
Vol 5 (0-2) ◽  
pp. 23
Author(s):  
Amalina Che Din ◽  
Celine Fong ◽  
Chon Sum Ong
Keyword(s):  
Subarachnoid Haemorrhage ◽  
Rare Case ◽  
Pituitary Apoplexy ◽  
Squamous Metaplasia ◽  
Csf Leak ◽  
Focal Lesion ◽  
Rathke’S Cleft Cyst ◽  
Rathke's Cleft Cyst ◽  
Stiff Neck ◽  
Rathke's Cleft

The occurrence of symptomatic Rathke's cleft cyst (RCC) apoplexy is extremely rare. This is often misdiagnosed due to similar presentations to subarachnoid haemorrhage and pituitary apoplexy. This case highlights an excellent example of similar clinical presentation and serves as a learning case for clinicians. A 40-year-old lady presented to a district hospital with 9 days of worsening severe headache associated with blurring of vision, photophobia, stiff neck, nausea and vomiting. Nuchal rigidity and Brudzinski’s positive. Blood test showed hyponatremia, raised inflammatory markers and normal dynamic pituitary function test. CT Head demonstrated no evidence of space-occupying lesion or intracranial haemorrhage. Lumbar puncture showed xanthochromia positive consistent with subarachnoid haemorrhage. MRI head advised by Neurosurgery team and revealed a focal lesion involving anterior pituitary macroadenoma with mass effect on optic chiasm with possible haemorrhage within. Further assessment in tertiary hospital confirmed loss of visual acuity and field deficit. Patient underwent emergency endoscopic transnasal transsphenoidal resection of apoplectic tumour and repair of CSF leak with graft from thigh. Histopathology report showed a Rathke’s cleft cyst with squamous metaplasia. Post operatively, the patient developed sinusitis which fully recovered, and MRI showed good decompression. The author demonstrated a rare case of symptomatic RCC which was initially presumed to be pituitary apoplexy. Radiology imaging and treatment approach for both conditions are quite similar and can only be differentiated by histopathology. Further research is required to identify the causes and risk factors of RCC apoplexy to aid early detection and diagnosis.International Journal of Human and Health Sciences Supplementary Issue-2: 2021 Page: S23

Rathke's cleft cyst mimiking pituitary apoplexy: a case report

2018 ◽  
Author(s):  
Ines Barka ◽  
Faiza Bensmaine ◽  
Moctar Bah ◽  
Clara Bouche ◽  
Jean Francois Gautier
Keyword(s):  
Case Report ◽  
Pituitary Apoplexy ◽  
Rathke’S Cleft Cyst ◽  
Rathke's Cleft Cyst ◽  
Rathke's Cleft

Rathke’s cleft cyst infections and pituitary abscesses: case series and review of the literature

Pituitary ◽  
2021 ◽  
Author(s):  
F. Aranda ◽  
R. García ◽  
F. J. Guarda ◽  
F. Nilo ◽  
J. P. Cruz ◽  
...  
Keyword(s):  
Case Series ◽  
Rathke’S Cleft Cyst ◽  
Review Of The Literature ◽  
Rathke's Cleft Cyst ◽  
Rathke's Cleft

Relationship between Recurrence Rates of Rathke's Cleft Cysts and Surgical Approaches to Sellar Reconstruction

2020 ◽  
Author(s):  
Rebecca Limb ◽  
James King
Keyword(s):  
Recurrence Rate ◽  
Case Series ◽  
Redo Surgery ◽  
Rathke’S Cleft Cyst ◽  
Recurrence Rates ◽  
Rathke's Cleft Cyst ◽  
Study Objective ◽  
Cyst Recurrence ◽  
Rathke's Cleft ◽  
Sellar Floor

Abstract Study Objective The main purpose of this article is to address the question of whether reconstructing the sellar floor following Rathke's cleft cyst excision results in increased rates of recurrence. Methods and Design A retrospective case series was compiled from medical records and radiological investigations at a single institution over a time period spanning 25 years. Episodes of cyst recurrence were determined from magnetic resonance imaging scans and outpatient encounters. Details regarding surgical procedure and techniques were obtained from operation notes. Perioperative morbidity was also recorded. Results Twenty-three adult patients were treated surgically for a Rathke's cleft cyst at the study institution between 1992 and 2017. The overall cyst recurrence rate was 48%, with 39% of all patients requiring redo surgery within the timeframe of the study. The mean time to redo surgery for recurrence was 4 years. Cyst recurrence rates were 57% postmicroscopic procedures, and 26% postendoscopic procedures (p = 0.148). In the nonreconstructed group, the recurrence rate was 17%, and in the reconstructed group the recurrence rate was 41% (p = 0.3792). Complications arising after nonreconstructive procedures were delayed cerebrospinal fluid rhinorrhea, pneumocephaly, and multiple episodes of meningitis. All these patients required return to theater for secondary reconstruction of the pituitary fossa floor. Conclusion The results of this small study suggest that reconstruction of the sellar floor, and microscopic rather than endoscopic techniques, may be associated with a higher rate of Rathke's cleft cyst recurrence. However, these trends did not reach statistical significance. Patients undergoing nonreconstructive procedures may be more prone to certain postoperative complications.

MRI Findings and Clinical Manifestations in Rathke's Cleft Cyst

1999 ◽  
Vol 141 (10) ◽  
pp. 1055-1061 ◽  
Author(s):  
N. Saeki ◽  
K. Sunami ◽  
Y. Sugaya ◽  
A. Yamaura
Keyword(s):  
Clinical Manifestations ◽  
Rathke’S Cleft Cyst ◽  
Mri Findings ◽  
Rathke's Cleft Cyst ◽  
Rathke's Cleft

Rathke's Cleft Cyst

1996 ◽  
Vol 37 (3P2) ◽  
pp. 596-598 ◽  
Author(s):  
K. Skjødt ◽  
A. Loft Edal ◽  
H. J. Nepper-Rasmussen
Keyword(s):  
Cyst Wall ◽  
Rathke’S Cleft Cyst ◽  
Cell Debris ◽  
Rathke's Cleft Cyst ◽  
Rathke's Cleft ◽  
Fast Field

Two patients with Rathke's cleft cyst with uncommon MR signals, hyperintensity on T1-weighted, and hypointensity on T2-weighted 3-D fast field echo (FFE) imaging are reported. We suggest that this is due to high content of cholesterol or mucopolysaccharide, possibly combined with cell debris from the cyst wall.

Sign in / Sign up

Export Citation Format

Share Document