Low grade astrocytoma in children under the age of three years: a report from the Canadian pediatric brain tumour consortium

2015 ◽  
Vol 124 (1) ◽  
pp. 95-100 ◽  
Author(s):  
Donna L. Johnston ◽  
Daniel Keene ◽  
Ute Bartels ◽  
Anne-Sophie Carret ◽  
Bruce Crooks ◽  
...  
Keyword(s):  
Brain Tumour ◽  
Low Grade ◽  
Pediatric Brain ◽  
Pediatric Brain Tumour

scholarly journals 44: Predicting IQ and the Risk of Hearing Loss Following Proton Versus Photon Radiotherapy for Pediatric Brain Tumour Patients

2016 ◽  
Vol 120 ◽  
pp. S17-S18
Author(s):  
Dominique Fortin ◽  
Angela Ng ◽  
Derek Tsang ◽  
Michael Sharpe ◽  
Normand Laperriere ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Brain Tumour ◽  
Pediatric Brain ◽  
Photon Radiotherapy ◽  
Pediatric Brain Tumour

The role of resection alone in select children with intracranial ependymoma: the Canadian Pediatric Brain Tumour Consortium experience

2014 ◽  
Vol 31 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Tamir Ailon ◽  
Christopher Dunham ◽  
Anne-Sophie Carret ◽  
Uri Tabori ◽  
P. Daniel Mcneely ◽  
...  
Keyword(s):  
Brain Tumour ◽  
Intracranial Ependymoma ◽  
Pediatric Brain ◽  
Pediatric Brain Tumour

Ependymoma in children under the age of 3 years: a report from the Canadian Pediatric Brain Tumour Consortium

2014 ◽  
Vol 117 (2) ◽  
pp. 359-364 ◽  
Author(s):  
Eve Purdy ◽  
Donna L. Johnston ◽  
Ute Bartels ◽  
Chris Fryer ◽  
Anne-Sophie Carret ◽  
...  
Keyword(s):  
Brain Tumour ◽  
Pediatric Brain ◽  
Pediatric Brain Tumour

scholarly journals Determination of SOX9 Gene Expression In Brain Tumours Among East Coast Malaysia Population

2020 ◽  
Vol 18 (2) ◽  
Author(s):  
Md Dzali NB ◽  
Wan Taib WR ◽  
Zahary MN ◽  
Abu Bakar NH ◽  
Abd Latif AZ ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Brain Tumour ◽  
Brain Tumours ◽  
East Coast ◽  
Rna Extraction ◽  
Slight Modification ◽  
Low Grade ◽  
Normal Brain ◽  
Sox9 Expression ◽  
Sox9 Gene

Introduction: SOX9, a members of SOX family, plays a significant roles in developmental processes during embryogenesis, including brain tissue. Few studies have shown that SOX9 has been involved in tumourigenesis of several types of cancer including brain tumour. However, such studies are still lacking in the Malaysian population. The aim of this study was to determine SOX9 expression level in several types of brain tumours in East Coast Malaysia. Materials and Methods: Five formalin-fixed pariffin-embedded brain tumour samples of Malay descendants were sectioned by using microtome. RNA extraction was performed with slight modification by adding Trizol during tissue lysis. The RNA was converted to cDNA using reverse transcription technique before SOX9 expression was detected using RT q-PCR assay in brain tumours normalized to non-neoplastic brain tissues. Results: Overall results displayed that SOX9 gene in all samples were up-regulated. SOX9 overexpression was found in both high and low grade glioma (anaplastic and pilocytic astrocytoma respectively). This is consistence with both low grade (benign) and atypical meningioma. Secondary brain tumour also showed up-regulation when compared to normal brain tissue. Conclusion: Up-regulation in SOX9 expression in selected brain tumours in Malay patients revealed its significant roles in brain tumourigenesis. Functional studies should be carried out to observe the SOX9 functions and mechanism whether they should reflect their diverse roles in Malaysia population.

Sign in / Sign up

Export Citation Format

Share Document