Outcome of gamma knife radiosurgery for metastatic brain tumors derived from non-small cell lung cancer

2015 ◽  
Vol 125 (2) ◽  
pp. 331-338 ◽  
Author(s):  
Kyung Rae Cho ◽  
Min Ho Lee ◽  
Doo-Sik Kong ◽  
Ho Jun Seol ◽  
Do-Hyun Nam ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Tumors ◽  
Small Cell Lung Cancer ◽  
Gamma Knife ◽  
Cell Lung Cancer ◽  
Gamma Knife Radiosurgery ◽  
Small Cell ◽  
Metastatic Brain Tumors ◽  
Small Cell Lung

Gamma Knife Radiosurgery for Treatment of Cerebral Metastases From Non–Small-Cell Lung Cancer

2011 ◽  
Vol 81 (4) ◽  
pp. e463-e468 ◽  
Author(s):  
Micaela Motta ◽  
Antonella del Vecchio ◽  
Luca Attuati ◽  
Piero Picozzi ◽  
Lucia. Perna ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Gamma Knife ◽  
Cell Lung Cancer ◽  
Gamma Knife Radiosurgery ◽  
Small Cell ◽  
Cerebral Metastases ◽  
Small Cell Lung

scholarly journals Prognosis of Non-Small Cell Lung Cancer with Synchronous Brain Metastases Treated with Gamma Knife Radiosurgery

2006 ◽  
Vol 21 (3) ◽  
pp. 527 ◽  
Author(s):  
Doo-Sik Kong ◽  
Jung-Il Lee ◽  
Do Hyun Nam ◽  
Kwan Park ◽  
Jong Hyun Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Metastases ◽  
Small Cell Lung Cancer ◽  
Gamma Knife ◽  
Cell Lung Cancer ◽  
Gamma Knife Radiosurgery ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Gamma Knife Radiosurgery for Brain Metastases in Non-Small Cell Lung Cancer Patients Treated with Immunotherapy or Targeted Therapy

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3668
Author(s):  
Anna Cho ◽  
Helena Untersteiner ◽  
Dorian Hirschmann ◽  
Abdallah Shaltout ◽  
Philipp Göbl ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Targeted Therapy ◽  
Brain Metastases ◽  
Small Cell Lung Cancer ◽  
Gamma Knife ◽  
Cell Lung Cancer ◽  
Combined Treatment ◽  
Gamma Knife Radiosurgery ◽  
Small Cell ◽  
Small Cell Lung

The combination of Gamma Knife radiosurgery (GKRS) and systemic immunotherapy (IT) or targeted therapy (TT) is a novel treatment method for brain metastases (BMs) in non-small cell lung cancer (NSCLC). To elucidate the safety and efficacy of concomitant IT or TT on the outcome after GKRS, 496 NSCLC patients with BMs, who were treated with GKRS were retrospectively reviewed. The median time between the initial lung cancer diagnosis and the diagnosis of brain metastases was one month. The survival after the initial BM diagnosis was significantly longer than the survival predicted by prognostic BM scores. After the first Gamma Knife radiosurgery treatment (GKRS1), the estimated median survival was 9.9 months (95% CI = 8.3–11.4). Patients with concurrent IT or TT presented with a significantly longer survival after GKRS1 than patients without IT or TT (p < 0.001). These significant differences in the survival were also apparent among the four treatment groups and remained significant after adjustment for Karnofsky performance status scale (KPS), recursive partitioning analysis (RPA) class, sex, and multiple BMs. About half of all our patients (46%) developed new distant BMs after GKRS1. Of note, no statistically significant differences in the occurrence of radiation reaction, radiation necrosis, or intralesional hemorrhage in association with IT or TT at or after GKRS1 were observed. In NSCLC-BM patients, the concomitant use of GKRS and IT or TT showed an increase in overall survival without increased complications related to GKRS. Therefore, the combined treatment with GKRS and IT or TT seems to be a safe and powerful treatment option and emphasizes the role of radiosurgery in modern BM treatment.

Growth rate of newly developed metastatic brain tumors after thoracotomy in patients with non-small cell lung cancer

Lung Cancer ◽  
2011 ◽  
Vol 71 (2) ◽  
pp. 205-208 ◽  
Author(s):  
Heon Yoo ◽  
Eugene Jung ◽  
Byung Ho Nam ◽  
Sang Hoon Shin ◽  
Ho Shin Gwak ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Rate ◽  
Brain Tumors ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Metastatic Brain Tumors ◽  
Small Cell Lung

scholarly journals Role of Gamma Knife Radiosurgery in Small Cell Lung Cancer: A Multi-Institutional Retrospective Study of the International Radiosurgery Research Foundation (IRRF)

Neurosurgery ◽  
2021 ◽  
Vol 89 (Supplement_2) ◽  
pp. S20-S20
Author(s):  
Christopher P Cifarelli ◽  
John A Vargo ◽  
Wei Fang ◽  
Roman Liscak ◽  
Khumar Guseynova ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Retrospective Study ◽  
Small Cell Lung Cancer ◽  
Gamma Knife ◽  
Cell Lung Cancer ◽  
Gamma Knife Radiosurgery ◽  
Small Cell ◽  
Small Cell Lung

Metastatic brain tumors from non-small cell lung cancer with EGFR mutations: Distinguishing influence of exon 19 deletion on radiographic features

Lung Cancer ◽  
2012 ◽  
Vol 77 (1) ◽  
pp. 64-69 ◽  
Author(s):  
Akimasa Sekine ◽  
Terufumi Kato ◽  
Eri Hagiwara ◽  
Takeshi Shinohara ◽  
Takanobu Komagata ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Tumors ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Egfr Mutations ◽  
Metastatic Brain Tumors ◽  
Small Cell Lung ◽  
Exon 19 Deletion ◽  
Exon 19

scholarly journals The Efficacy of Postoperative Chemotherapy for Patients with Metastatic Brain Tumors from Non-Small Cell Lung Cancer

2015 ◽  
Vol 3 (2) ◽  
pp. 108
Author(s):  
Noah Hong ◽  
Jung Nam Joo ◽  
Sang Hoon Shin ◽  
Ho Shin Gwak ◽  
Seung Hoon Lee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Tumors ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Postoperative Chemotherapy ◽  
Metastatic Brain Tumors ◽  
Small Cell Lung
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