Role of ERK in Hydrogen Peroxide-Induced Cell Death of Human Glioma Cells

2005 ◽  
Vol 30 (2) ◽  
pp. 263-270 ◽  
Author(s):  
Won Chang Lee ◽  
Chang Hwa Choi ◽  
Seung Heon Cha ◽  
Hyun Lim Oh ◽  
Yong Keun Kim
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells

scholarly journals Differential expression and role of p21cip/waf1 and p27kip1 in TNF-α-induced inhibition of proliferation in human glioma cells

2007 ◽  
Vol 6 (1) ◽  
pp. 42 ◽  
Author(s):  
Pabbisetty Kumar ◽  
Anjali Shiras ◽  
Gowry Das ◽  
Jayashree C Jagtap ◽  
Vandna Prasad ◽  
...  
Keyword(s):  
Differential Expression ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Inhibition Of Proliferation ◽  
Tnf Α

15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) Induces Cell Death Through Caspase-independent Mechanism in A172 Human Glioma Cells

2006 ◽  
Vol 31 (10) ◽  
pp. 1247-1254 ◽  
Author(s):  
W. H. Cho ◽  
C. H. Choi ◽  
J. Y. Park ◽  
S. K. Kang ◽  
Y. K. Kim
Keyword(s):  
Cell Death ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Independent Mechanism ◽  
Prostaglandin J2

scholarly journals Diva/Boo is a negative regulator of cell death in human glioma cells

FEBS Letters ◽  
2001 ◽  
Vol 505 (1) ◽  
pp. 23-26 ◽  
Author(s):  
Ulrike Naumann ◽  
Simone Weit ◽  
Jörg Wischhusen ◽  
Michael Weller
Keyword(s):  
Cell Death ◽  
Glioma Cells ◽  
Negative Regulator ◽  
Human Glioma ◽  
Human Glioma Cells

Synergistic cytotoxicity through the activation of multiple apoptosis pathways in human glioma cells induced by combined treatment with ionizing radiation and tumor necrosis factor–related apoptosis-inducing ligand

2007 ◽  
Vol 106 (3) ◽  
pp. 407-416 ◽  
Author(s):  
Motoo Nagane ◽  
Webster K. Cavenee ◽  
Yoshiaki Shiokawa
Keyword(s):  
Cell Death ◽  
Ionizing Radiation ◽  
Combination Treatment ◽  
Tumor Necrosis ◽  
Malignant Gliomas ◽  
Glioma Cells ◽  
Caspase 8 ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Necrosis Factor

Object Malignant gliomas remain incurable despite modern multimodality treatments. Tumor necrosis factor (TNF)–related apoptosis-inducing ligand (TRAIL), also known as Apo2L, a member of the TNF family, preferentially induces apoptosis in human tumor cells through its cognate death receptors DR4 or DR5, suggesting that it may serve as a potential therapeutic agent for intractable malignant gliomas. Here, the authors show that genotoxic ionizing radiation synergistically enhances TRAIL-induced cell death in human glioma cells expressing DR5. Methods Combination treatment with soluble human TRAIL plus radiation induced robust cell death, while each of them singly led to only limited cytotoxicity. The combination resulted in cleavage and activation of the apoptotic initiator caspase-8 and the effector caspase-3 as well as cleavage of Bid and another initiator caspase-9, a downstream component of the apoptosome. Accordingly, it augmented the release of cytochrome c from the mitochondria into the cytosol, as well as apoptosis-inducing factor. Synergistic cell death was suppressed by TRAIL-neutralizing DR5-Fc, caspase inhibitors, expression of dominant-negative Fasassociated protein with death domain and CrmA, which selectively blocks caspase-8, and overexpression of Bcl-XL. Finally, combination treatment had no influence on the viability of normal human astrocytes. Conclusions These results suggest that combination treatment with TRAIL and ionizing radiation kills human glioma cells through the activation of DR5-mediated death receptor pathways. This therapy involves direct activation of effector caspases as well as mitochondria-mediated pathways and provides a novel strategy in which TRAIL could be synergistically combined with DNA-damaging radiation.

Protection Against Arsenic Trioxide-Induced Autophagic Cell Death in U118 Human Glioma Cells by Use of Lipoic Acid

Epidemiology ◽  
2006 ◽  
Vol 17 (Suppl) ◽  
pp. S495-S496
Author(s):  
Y J Wang ◽  
T J Cheng ◽  
W W Kao ◽  
R J Chen ◽  
Y S Ho
Keyword(s):  
Cell Death ◽  
Arsenic Trioxide ◽  
Lipoic Acid ◽  
Glioma Cells ◽  
Autophagic Cell Death ◽  
Human Glioma ◽  
Human Glioma Cells

Video-enhanced microscopic visualization of apoptotic cell death caused by anti-Fas antibody in living human glioma cells

1998 ◽  
Vol 15 (1) ◽  
pp. 19-21
Author(s):  
Seiji Ohta ◽  
Jun Yoshida ◽  
Seiji Yamamoto ◽  
Kenichi Uemura ◽  
Toshihiko Wakabayashi ◽  
...  
Keyword(s):  
Cell Death ◽  
Apoptotic Cell ◽  
Glioma Cells ◽  
Apoptotic Cell Death ◽  
Human Glioma ◽  
Human Glioma Cells

scholarly journals The role of IFITM3 in the growth and migration of human glioma cells

BMC Neurology ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Bing Zhao ◽  
Hongliang Wang ◽  
Gang Zong ◽  
Ping Li
Keyword(s):  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
And Migration

scholarly journals P04.50 Doxycycline impairs mitochondrial function and protects human glioma cells from hypoxia-induced cell death: implications of using Tet-inducible systems

2018 ◽  
Vol 20 (suppl_3) ◽  
pp. iii290-iii290
Author(s):  
B Sauer ◽  
A Luger ◽  
N I Lorenz ◽  
A L Engel ◽  
Y Braun ◽  
...  
Keyword(s):  
Cell Death ◽  
Mitochondrial Function ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Inducible Systems
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