Peripheral Nerve Injury Induces Down-Regulation of Foxo3a and p27kip1 in Rat Dorsal Root Ganglia

2008 ◽  
Vol 34 (5) ◽  
pp. 891-898 ◽  
Author(s):  
Youhua Wang ◽  
Yonghua Liu ◽  
Ying Chen ◽  
Shuxian Shi ◽  
Jing Qin ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Dorsal Root Ganglia ◽  
Peripheral Nerve Injury ◽  
Dorsal Root ◽  
Down Regulation

scholarly journals Genome-wide redistribution of MeCP2 in dorsal root ganglia after peripheral nerve injury

2016 ◽  
Vol 9 (1) ◽  
Author(s):  
Melissa T. Manners ◽  
Adam Ertel ◽  
Yuzhen Tian ◽  
Seena K. Ajit
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Dorsal Root Ganglia ◽  
Peripheral Nerve Injury ◽  
Dorsal Root ◽  
Genome Wide

Changes in voltage-gated calcium channel α1 gene expression in rat dorsal root ganglia following peripheral nerve injury

2001 ◽  
Vol 96 (1-2) ◽  
pp. 151-156 ◽  
Author(s):  
Dong-Sun Kim ◽  
Chul-Ho Yoon ◽  
Sang-Ji Lee ◽  
So-Yun Park ◽  
Hea-Jin Yoo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Peripheral Nerve ◽  
Calcium Channel ◽  
Nerve Injury ◽  
Dorsal Root Ganglia ◽  
Peripheral Nerve Injury ◽  
Dorsal Root ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel

Upregulation of Ryk expression in rat dorsal root ganglia after peripheral nerve injury

2008 ◽  
Vol 77 (4) ◽  
pp. 178-184 ◽  
Author(s):  
Xin Li ◽  
Yao-hua Li ◽  
Shun Yu ◽  
Yaobo Liu
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Dorsal Root Ganglia ◽  
Peripheral Nerve Injury ◽  
Dorsal Root

miRNA Expression Change in Dorsal Root Ganglia After Peripheral Nerve Injury

2016 ◽  
Vol 61 (2) ◽  
pp. 169-177 ◽  
Author(s):  
Hsueh-Ling Chang ◽  
Hung-Chen Wang ◽  
Yi-Ta Chunag ◽  
Chao-Wen Chou ◽  
I-Ling Lin ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Dorsal Root Ganglia ◽  
Mirna Expression ◽  
Peripheral Nerve Injury ◽  
Dorsal Root ◽  
Expression Change

scholarly journals Sexual Dimorphism of Early Transcriptional Reprogramming in Dorsal Root Ganglia After Peripheral Nerve Injury

2021 ◽  
Vol 14 ◽  
Author(s):  
Andrei V. Chernov ◽  
Veronica I. Shubayev
Keyword(s):  
Immune Response ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Dorsal Root Ganglia ◽  
Peripheral Nerve Injury ◽  
Dorsal Root ◽  
Sexually Dimorphic ◽  
Matrix Remodeling ◽  
Immune Functions ◽  
Transcriptional Reprogramming

Peripheral nerve injury induces genome-wide transcriptional reprogramming of first-order neurons and auxiliary cells of dorsal root ganglia (DRG). Accumulating experimental evidence suggests that onset and mechanistic principles of post-nerve injury processes are sexually dimorphic. We examined largely understudied aspects of early transcriptional events in DRG within 24 h after sciatic nerve axotomy in mice of both sexes. Using high-depth RNA sequencing (>50 million reads/sample) to pinpoint sexually dimorphic changes related to regeneration, immune response, bioenergy, and sensory functions, we identified a higher number of transcriptional changes in male relative to female DRG. In males, the decline in ion channel transcripts was accompanied by the induction of innate immune cascades via TLR, chemokine, and Csf1-receptor axis and robust regenerative programs driven by Sox, Twist1/2, and Pax5/9 transcription factors. Females demonstrated nerve injury-specific transcriptional co-activation of the actinin 2 network. The predicted upstream regulators and interactive networks highlighted the role of novel epigenetic factors and genetic linkage to sex chromosomes as hallmarks of gene regulation post-axotomy. We implicated epigenetic X chromosome inactivation in the regulation of immune response activity uniquely in females. Sexually dimorphic regulation of MMP/ADAMTS metalloproteinases and their intrinsic X-linked regulator Timp1 contributes to extracellular matrix remodeling integrated with pro-regenerative and immune functions. Lexis1 non-coding RNA involved in LXR-mediated lipid metabolism was identified as a novel nerve injury marker. Together, our data identified unique early response triggers of sex-specific peripheral nerve injury regulation to gain mechanistic insights into the origin of female- and male-prevalent sensory neuropathies.

Sign in / Sign up

Export Citation Format

Share Document