Retinal Metabolic Changes in an Experimental Model of Optic Nerve Transection by Ex Vivo 1H Magnetic Resonance Spectroscopy

2011 ◽  
Vol 36 (12) ◽  
pp. 2427-2433 ◽  
Author(s):  
Shuang Li ◽  
Mingming Huang ◽  
Xinghua Wang ◽  
Xuxia Wang ◽  
Fei Chen ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Experimental Model ◽  
Ex Vivo ◽  
Metabolic Changes ◽  
Resonance Spectroscopy ◽  
Nerve Transection ◽  
1H Magnetic Resonance Spectroscopy ◽  
Optic Nerve Transection

1H magnetic resonance spectroscopy of preinvasive and invasive cervical cancer: In vivo-ex vivo profiles and effect of tumor load

2004 ◽  
Vol 19 (3) ◽  
pp. 356-364 ◽  
Author(s):  
Marrita M. Mahon ◽  
I. Jane Cox ◽  
Roberto Dina ◽  
W. Patrick Soutter FRCOG ◽  
G. Angus McIndoe MRCOG ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Ex Vivo ◽  
Invasive Cervical Cancer ◽  
Resonance Spectroscopy ◽  
1H Magnetic Resonance Spectroscopy ◽  
Tumor Load

scholarly journals In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment

2009 ◽  
Vol 10 (1) ◽  
Author(s):  
Eric Westman ◽  
Christian Spenger ◽  
Johanna Öberg ◽  
Henry Reyer ◽  
Jens Pahnke ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Metabolic Changes ◽  
Resonance Spectroscopy ◽  
1H Magnetic Resonance Spectroscopy

scholarly journals Metabolic Changes Associated with a Rat Model of Diabetic Depression Detected by Ex Vivo 1H Nuclear Magnetic Resonance Spectroscopy in the Prefrontal Cortex, Hippocampus, and Hypothalamus

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Kun Liu ◽  
Liangcai Zhao ◽  
Wen Xu ◽  
Qiuting Lin ◽  
Yongjin Zhou ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Prefrontal Cortex ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Nuclear Magnetic Resonance Spectroscopy ◽  
Ex Vivo ◽  
Metabolic Changes ◽  
Resonance Spectroscopy ◽  
Diabetic Patients ◽  
Nuclear Magnetic

Diabetic patients often present with comorbid depression. However, the pathogenetic mechanisms underlying diabetic depression (DD) remain unclear. To explore the mechanisms underpinning the pathogenesis of the disease, we used ex vivo 1H nuclear magnetic resonance spectroscopy and immunohistochemistry to investigate the main metabolic and pathological changes in various rat brain areas in an animal model of DD. Compared with the control group, rats in the DD group showed significant decreases in neurotransmitter concentrations of glutamate (Glu) and glutamine (Gln) in the prefrontal cortex (PFC), hippocampus, and hypothalamus and aspartate and glycine in the PFC and hypothalamus. Gamma-aminobutyric acid (GABA) was decreased only in the hypothalamus. Levels of the energy product, lactate, were higher in the PFC, hippocampus, and hypothalamus of rats with DD than those in control rats, while creatine was lower in the PFC and hippocampus, and alanine was lower in the hypothalamus. The levels of other brain metabolites were altered, including N-acetyl aspartate, taurine, and choline. Immunohistochemistry analysis revealed that expressions of both glutamine synthetase and glutaminase were decreased in the PFC, hippocampus, and hypothalamus of rats with DD. The metabolic changes in levels of Glu, Gln, and GABA indicate an imbalance of the Glu-Gln metabolic cycle between astrocytes and neurons. Our results suggest that the development of DD in rats may be linked to brain metabolic changes, including inhibition of the Glu-Gln cycle, increases in anaerobic glycolysis, and disturbances in the lactate-alanine shuttle, and associated with dysfunction of neurons and astrocytes.

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