Solid-Phase Fluorimetric Determination of Some Nonsteroidal Anti-Inflammatory Drugs in Medicines with the Aid of a Smartphone

2022 ◽  
Author(s):  
V. G. Amelin ◽  
Z. A. Ch. Shogah ◽  
D. S. Bol’shakov
Keyword(s):  
Solid Phase ◽  
Fluorimetric Determination ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Determination of selected acidic pharmaceuticals and caffeine in Ergene basin, in Turkey

2013 ◽  
Vol 15 (4) ◽  
pp. 431-439 ◽  
Keyword(s):  
Salicylic Acid ◽  
Solid Phase ◽  
Treatment Plant ◽  
Gas Chromatography Mass Spectrometry ◽  
Industrial District ◽  
Plant Site ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Concentration Levels

<p>In this study, surface and wastewater in Çorlu, Tekirdağ has been monitored for ibuprofen, naproxen and diclofenac as non-steroidal anti-inflammatory drugs (NSAIDs), salicylic acid as an analgesic and caffeine. For this goal, samples were collected from 5 areas during winter and summer times (W1, W2, W3, W4 and W5) working in the field of a wastewater treatment plant site, only Çerkezköy industrial district W4. Different solid-phase extractions, pH and derivatization conditions were tested with some anti-inflammatory drugs and caffeine of Gas-Chromatography-Mass Spectrometry in environment samples and their identification and quantification at trace levels were made (ng L-1). Diclofenac (LOQ = 4.3 ng L-1) and ibuprofen (LOQ = 134.1 ng L-1) could not be determined. Other concentration levels of arranged drugs range between 2.12 -13.58 ng L-1 naproxen, 15.74-18.74 ng L-1 salicylic acid and 5.8-121.2 ng L-1 caffeine.</p>

Rapid and simultaneous determination of nonsteroidal anti-inflammatory drugs in human plasma by LC–MS with solid-phase extraction

2006 ◽  
Vol 384 (7-8) ◽  
pp. 1501-1505 ◽  
Author(s):  
Koichi Suenami ◽  
Lee Wah Lim ◽  
Toyohide Takeuchi ◽  
Yasuhide Sasajima ◽  
Kiyohito Sato ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Simultaneous Determination ◽  
Human Plasma ◽  
Solid Phase ◽  
Phase Extraction ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Determination of non-steroidal anti-inflammatory drugs in wastewaters by magnetic matrix solid phase dispersion–HPLC

Talanta ◽  
2010 ◽  
Vol 80 (3) ◽  
pp. 1152-1157 ◽  
Author(s):  
K. Aguilar-Arteaga ◽  
J.A. Rodriguez ◽  
J.M. Miranda ◽  
J. Medina ◽  
E. Barrado
Keyword(s):  
Solid Phase ◽  
Matrix Solid Phase Dispersion ◽  
Phase Dispersion ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Malihe Khoeini Sharifabadi ◽  
Mohammad Saber-Tehrani ◽  
Syed Waqif Husain ◽  
Ali Mehdinia ◽  
Parviz Aberoomand-Azar
Keyword(s):  
Magnetic Nanoparticles ◽  
Cetyltrimethylammonium Bromide ◽  
Limit Of Detection ◽  
Solid Phase ◽  
Aqueous Sample ◽  
Relative Standard ◽  
Separation And Preconcentration ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

A simple and sensitive solid-phase extraction method for separation and preconcentration of trace amount of four nonsteroidal anti-inflammatory drugs (naproxen, indomethacin, diclofenac, and ibuprofen) using Fe3O4magnetic nanoparticles modified with cetyltrimethylammonium bromide has been developed. For this purpose, the surface ofMNPswas modified with cetyltrimethylammonium bromide (CTAB) as a cationic surfactant. Effects of different parameters influencing the extraction efficiency of drugs including the pH, amount of salt, shaking time, eluent type, the volume of solvent, amount of adsorbent, sample volume, and the time of desorption were investigated and optimized. Methanol has been used as desorption solvent and the extracts were analysed on a reversed-phase octadecyl silica column using 0.02 M phosphate-buffer (pH = 6.02) acetonitrile (65 : 35 v/v) as the mobile phase and the effluents were measured at 202 nm with ultraviolet detector. The relative standard deviation (RSD%) of the method was investigated at three concentrations (25, 50, and 200 ng/mL) and was in the range of 3.98–9.83%(n=6)for 50 ng/mL. The calibration curves obtained for studied drugs show reasonable linearity(R2>0.99)and the limit of detection(LODs)ranged between 2 and 7 ng/mL. Finally, the proposed method has been effectively employed in extraction and determination of the drugs in biological and environmental samples.

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